Lepre1
Gene Detail

Symbol Name ID

Lepre1 leprecan 1 MGI:1888921

Synonyms

2410024C15Rik, Gros1, P3H1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

55.34 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:119232915-119248975 bp, + strand From VEGA annotation of GRCm38   16061 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lepre1

Human homologs

Human Homolog		LEPRE1, leucine proline-enriched proteoglycan (leprecan) 1
NCBI Gene ID		64175
neXtProt AC		NX_Q32P28
Human Synonyms		GROS1, OI8, P3H1
Human Chr (Location)		1p34.1; chr1:43212006-43232755 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LEPRE1

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for a knock-out allele exhibit reduced size, disproportional reduction in long bone length, decreased bone density, decreased bone mineral density, reduced body fat, delayed ossification, and abnormal collagen networks in the skin and tendons.

 
Human Diseases Modeled Using Mouse Lepre1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell growth, collagen fibril organization, ...
Component	basement membrane, cytoplasm, ...
Function	iron ion binding, L-ascorbic acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (212)    Tissues (84)    Images (44)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	188
Northern blot	6
RT-PCR	18

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) cDNA(64) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009225 (Evidence)
Ensembl Gene Model	ENSMUSG00000028641 (Evidence)
Entrez Gene	56401 (Evidence)
UniGene	27961
DFCI	TC1575983, TC1596073
NIA Mouse Gene Index	U004736
EC	1.14.11.7
Consensus CDS Project	CCDS18576.1, CCDS38859.1, CCDS38860.1
International Mouse Knockout Project Status	Lepre1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009225	VEGA Gene Model | MGI Sequence Detail	16061	C57BL/6J
transcript	OTTMUST00000020882	VEGA | MGI Sequence Detail	2977	Not Applicable
polypeptide	OTTMUSP00000009572	VEGA | MGI Sequence Detail	748	Not Applicable

All sequences(67) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005123	Oxoglutarate/iron-dependent dioxygenase
InterPro	IPR006620	Prolyl 4-hydroxylase, alpha subunit
InterPro	IPR011990	Tetratricopeptide-like helical
Protein Ontology	PR:000009759	prolyl 3-hydroxylase 1

References

(Earliest) J:95868 Wassenhove-McCarthy DJ, et al., Molecular characterization of a novel basement membrane-associated proteoglycan, leprecan. J Biol Chem. 1999 Aug 27;274(35):25004-17
(Latest) J:194203 Pokidysheva E, et al., Prolyl 3-hydroxylase-1 null mice exhibit hearing impairment and abnormal morphology of the middle ear bone joints. Matrix Biol. 2013 Jan;32(1):39-44
All references(41)

Other accession IDs

MGI:1919438