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Lepre1
Gene Detail
 Symbol
Name
ID
Lepre1
leprecan 1
MGI:1888921
Synonyms 2410024C15Rik, Gros1, P3H1
Feature Type protein coding gene
Genetic Map
Chromosome 4
55.34 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:119232915-119248975 bp, + strand
From VEGA annotation of GRCm38

  16061 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lepre1

Human
homologs
Human Homolog LEPRE1, leucine proline-enriched proteoglycan (leprecan) 1
NCBI Gene ID 64175
neXtProt AC  NX_Q32P28
Human Synonyms  GROS1, OI8, P3H1
Human Chr (Location)  1p34.1; chr1:42746335-42767084 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LEPRE1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced size, disproportional reduction in long bone length, decreased bone density, decreased bone mineral density, reduced body fat, delayed ossification, and abnormal collagen networks in the skin and tendons.
 
Human Diseases Modeled Using Mouse Lepre1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Lepre1 interacts with 244 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process bone development, cell growth, ...
Component basement membrane, cytoplasm, ...
Function dioxygenase activity, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (212)    Tissues (84)    Images (44)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 23, 25, 28
Assay TypeResults
RNA in situ 188
Northern blot 6
RT-PCR 18
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(64) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009225 (Evidence)
Ensembl Gene ModelENSMUSG00000028641 (Evidence)
Entrez Gene56401 (Evidence)
UniGene27961
DFCITC1575983, TC1596073
NIA Mouse Gene IndexU004736
EC1.14.11.7
Consensus CDS ProjectCCDS18576.1, CCDS38859.1, CCDS38860.1, CCDS71460.1
International Mouse Knockout Project StatusLepre1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009225 VEGA Gene Model | MGI Sequence Detail 16061 C57BL/6J ±  kb
transcript OTTMUST00000020882 VEGA | MGI Sequence Detail 2977 Not Applicable 
polypeptide OTTMUSP00000009572 VEGA | MGI Sequence Detail 748 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(152 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000009759 prolyl 3-hydroxylase 1
References (Earliest) J:95868 Wassenhove-McCarthy DJ, et al., Molecular characterization of a novel basement membrane-associated proteoglycan, leprecan. J Biol Chem. 1999 Aug 27;274(35):25004-17
(Latest) J:204353 Homan EP, et al., Differential effect of collagen prolyl 3-hydroxylation on skeletal tissues. PLoS Genet. 2014;10(1):e1004121
All references(45)
Disease annotation references (1)
Other
accession IDs
MGI:1919438

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory