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Cyp2c23 Gene Detail
Summary
  • Symbol
    Cyp2c23
  • Name
    cytochrome P450, family 2, subfamily c, polypeptide 23
  • Synonyms
    Cyp2c44, MGC:25860, MGC:37835, MGC:37849
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888897
    NCBI Gene: 226143
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:44005022-44029208 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888897
protein coding gene Chr19:44005022-44029256 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025161
protein coding gene Chr19:43451679-43480982 (-)
A/J MGP_AJ_G0025138
protein coding gene Chr19:41377978-41402746 (-)
AKR/J MGP_AKRJ_G0025106
protein coding gene Chr19:42686430-42714018 (-)
BALB/cJ MGP_BALBcJ_G0025132
protein coding gene Chr19:41423354-41448115 (-)
C3H/HeJ MGP_C3HHeJ_G0024892
protein coding gene Chr19:42861813-42887282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025575
protein coding gene Chr19:44510627-44543845 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022989
protein coding gene Chr19:40673403-40695570 (-)
CAST/EiJ MGP_CASTEiJ_G0024357
protein coding gene Chr19:42566994-42599461 (-)
CBA/J MGP_CBAJ_G0024872
protein coding gene Chr19:46721664-46762747 (-)
DBA/2J MGP_DBA2J_G0025004
protein coding gene Chr19:41202020-41227688 (-)
FVB/NJ MGP_FVBNJ_G0024965
protein coding gene Chr19:40964986-40988992 (-)
LP/J MGP_LPJ_G0025090
protein coding gene Chr19:43409431-43437822 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024996
protein coding gene Chr19:46249651-46279932 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025633
protein coding gene Chr19:42773973-42799721 (-)
PWK/PhJ MGP_PWKPhJ_G0024106
protein coding gene Chr19:41103577-41128863 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023910
protein coding gene Chr19:41489943-41514833 (-)
WSB/EiJ MGP_WSBEiJ_G0024427
protein coding gene Chr19:42909830-42939466 (-)



Homology
more
  • Human Ortholog
    CYP2C23P, cytochrome P450 family 2 subfamily C member 23, pseudogene
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CYP2C23P, cytochrome P450 family 2 subfamily C member 23, pseudogene
    Orthology source: HGNC
  • Synonyms
    CYP2C62P
  • Links
    NCBI Gene ID: 107436076

  • Chr Location
    10q24.32; chr10:101895146-101895281 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele show reduced proliferative and tubulogenic responses in lung endothelial cells, decreased tumor angiogenesis and growth of induced tumors, and high potassium-induced hypertension with decreased urinary sodium excretion and increased plasma sodium levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025197 Ensembl Gene Model | MGI Sequence Detail 24187 C57BL/6J ±  kb
    transcript ENSMUST00000026211 Ensembl | MGI Sequence Detail 1916 Not Applicable  
    polypeptide ENSMUSP00000026211 Ensembl | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR001128 Cytochrome P450
      IPR017972 Cytochrome P450, conserved site
      IPR020469 Cytochrome P450, CYP2 family
      IPR002401 Cytochrome P450, E-class, group I
      IPR008067 Cytochrome P450, E-class, group I, CYP2A-like
      IPR036396 Cytochrome P450 superfamily
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147705, MGI:2675854
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:243885 Hashimoto R, et al., Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2017 Aug 01;313(2):H293-H303

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    04/16/2019
    MGI 6.13
    The Jackson Laboratory