About   Help   FAQ
Ppbp Gene Detail
Summary
  • Symbol
    Ppbp
  • Name
    pro-platelet basic protein
  • Synonyms
    2400003M24Rik, beta-TG, b-TG1, CTAP3, CTAPIII, Cxcl7, LA-PF4, LDGF, MDGF, NAP-2, NAP-2, NAP-2-L1, Scyb7, TGB, TGB1, THBGB1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888712
    NCBI Gene: 57349
  • Gene Overview
    MyGene.info: PPBP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:90768518-90770063 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1546 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PPBP, pro-platelet basic protein
  • Vertebrate Orthologs
    2
  • Human Ortholog
    PPBP, pro-platelet basic protein
    Orthology source: HGNC
  • Synonyms
    Beta-TG, B-TG1, CTAP3, CTAPIII, CTAP-III, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
  • Links
    NCBI Gene ID: 5473
    neXtProt AC: NX_P02775
    UniProt: P02775

  • Chr Location
    4q13.3; chr4:73986439-73988190 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired leukocyte shape change and migration following vascular injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055504 VEGA Gene Model | MGI Sequence Detail 1546 C57BL/6J ±  kb
    transcript OTTMUST00000137379 VEGA | MGI Sequence Detail 1083 Not Applicable  
    polypeptide OTTMUSP00000072359 VEGA | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      66 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR001811 Chemokine interleukin-8-like domain
      IPR036048 Chemokine interleukin-8-like superfamily
      IPR001089 CXC chemokine
      IPR033899 CXC Chemokine domain
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922842, MGI:2141003
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:256174 Bdeir K, et al., Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 Feb;56(2):261-270

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory