Pf4 MGI Mouse Gene Detail - MGI:1888711

Symbol

Pf4
Name

platelet factor 4
Synonyms

Cxcl4, Pf4, Scyb4

Feature Type

protein coding gene
IDs

MGI:1888711
NCBI Gene: 56744
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:90920362-90921242 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.78 cM
Mapping Data

2 experiments

SNPs within 2kb

69 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888711	protein coding gene	Chr5:90920294-90921242 (+)
129S1/SvImJ	ENSMUSG00200007696	protein coding gene	Chr5:86654325-86655273 (+)
A/J	ENSMUSG00195024186	protein coding gene	Chr5:85823059-85824007 (+)
AKR/J	ENSMUSG00220012021	protein coding gene	Chr5:85968701-85969649 (+)
BALB/cJ	ENSMUSG00180022327	protein coding gene	Chr5:85682657-85683605 (+)
C3H/HeJ	ENSMUSG00175036759	protein coding gene	Chr5:87778274-87779222 (+)
C57BL/6NJ	ENSMUSG00215022793	protein coding gene	Chr5:86516028-86516976 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027394	protein coding gene	Chr5:83941714-83942666 (+)
CAST/EiJ	ENSTCUG00005033460	protein coding gene	Chr5:85427584-85428531 (+)
CBA/J	ENSMUSG00210005548	protein coding gene	Chr5:86578052-86579000 (+)
DBA/2J	ENSMUSG00185037408	protein coding gene	Chr5:88499007-88499955 (+)
FVB/NJ	ENSMUSG00205019688	protein coding gene	Chr5:85398848-85399796 (+)
JF1/MsJ	ENSUMUG00000040669	protein coding gene	Chr5:92777790-92778738 (+)
LP/J	ENSMUSG00230023487	protein coding gene	Chr5:93180671-93181619 (+)
NOD/ShiLtJ	ENSMUSG00190029272	protein coding gene	Chr5:85460547-85461495 (+)
NZO/HlLtJ	ENSMUSG00225008416	protein coding gene	Chr5:98328196-98329144 (+)
PWK/PhJ	ENSLUMG00010025621	protein coding gene	Chr5:85447843-85448791 (+)
SPRET/EiJ	ENSMSPG00010033866	protein coding gene	Chr5:87849799-87850743 (+)
WSB/EiJ	ENSIUOG00005028920	protein coding gene	Chr5:88462328-88463276 (+)

Human Ortholog

PF4, platelet factor 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PF4, platelet factor 4
Synonyms

CXCL4, PF-4, SCYB4
Links

HGNC:8861

NCBI Gene ID: 5196

UniProt: P02776
Chr Location

4q13.3; chr4:73980811-73982124 (-) GRCh38

Human Ortholog

PF4V1, platelet factor 4 variant 1
Synonyms

CXCL4L1, CXCL4V1, PF4A, PF4-ALT, SCYB4V1
Links

HGNC:8862

NCBI Gene ID: 5197

UniProt: P10720
Chr Location

4q13.3; chr4:73853296-73854483 (+) GRCh38

MGI Vertebrate Homology

Pf4 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PF4, PF4V1
Gene Tree

Pf4

Diseases

1 with human PF4 associations

				Human Disease	Mouse Models
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

11
Radiation induced

1
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Pf4
Find Mice (IMSR)

18 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous and heterozygous null mice display increased platelet counts and reduced thrombus formation following vascular injury.

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All GO Annotations

47
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

50
cDNA Data

32
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

4
CCDS

CCDS19416.1

Ensembl

ENSMUSG00000029373 (Evidence)
NCBI Gene

56744

			Length	Strain/Species	Flank
genomic	56744	NCBI Gene Model \| MGI Sequence Detail	881	C57BL/6J	± kb
transcript	NM_019932	RefSeq \| MGI Sequence Detail	520	C57BL/6
polypeptide	Q9Z126	UniProt \| EBI \| MGI Sequence Detail	105	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012569 platelet factor 4

(term hierarchy)
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR018048 CXC chemokine, conserved site

IPR033899 CXC Chemokine domain
GlyGen

Q9Z126 1 site

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All nucleic 39

cDNA 32

Primer pair 6

Other 1

Antibodies 1

Microarray probesets 3

Summaries

All 110

Developmental Gene Expression 15

Gene Ontology 9

Phenotypes 54
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:385797 Xia M, et al., A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity. Dev Cell. 2026 May 11;

TSS for Pf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47187	Chr5:90919484-90919489 (+)	-875 bp
Tssr47188	Chr5:90919919-90919930 (+)	-437 bp
Tssr47189	Chr5:90920328-90920339 (+)	-28 bp
Tssr47190	Chr5:90920352-90920368 (+)	-2 bp
Tssr47191	Chr5:90920396-90920410 (+)	41 bp
Tssr47192	Chr5:90921046-90921059 (+)	691 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29