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Pf4
Gene Detail
 Symbol
Name
ID
Pf4
platelet factor 4
MGI:1888711
Synonyms Cxcl4, Pf4, Scyb4
Feature Type protein coding gene
Genetic Map
Chromosome 5
44.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:90772435-90773381 bp, + strand
From Ensembl annotation of GRCm38

  947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87791  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: CXC chemokine
Gene Tree: Pf4

Human
homologs
Human Homolog PF4, platelet factor 4
NCBI Gene ID 5196
neXtProt AC  NX_P02776
Human Synonyms  CXCL4, PF-4, SCYB4
Human Chr (Location)  4q12-q21; chr4:73980825-73982124 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous and heterozygous null mice display increased platelet counts and reduced thrombus formation following vascular injury.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process chemotaxis, cytokine-mediated signaling pathway, ...
Component extracellular region, extracellular space, ...
Function chemokine activity, CXCR3 chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (175)    Tissues (46)    Images (37)
Theiler Stages: 11, 13, 15, 17, 19, 20, 22, 23, 28
Assay TypeResults
RNA in situ 166
RT-PCR 9
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029373 (Evidence)
Entrez Gene56744 (Evidence)
UniGene332490
DFCITC1581227, TC1767251
DoTSDT.102519772, DT.97337465
NIA Mouse Gene IndexU005782
Consensus CDS ProjectCCDS19416.1
International Mouse Knockout Project StatusPf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029373 Ensembl Gene Model | MGI Sequence Detail 947 C57BL/6J ±  kb
transcript ENSMUST00000031320 Ensembl | MGI Sequence Detail 586 Not Applicable 
polypeptide ENSMUSP00000031320 Ensembl | MGI Sequence Detail 105 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001811 Chemokine interleukin-8-like domain
InterPro IPR001089 CXC chemokine
InterPro IPR018048 CXC chemokine, conserved site
InterPro IPR027222 Platelet factor 4
Protein Ontology PR:000012569 platelet factor 4
References (Earliest) J:52615 Thomasset N, et al., Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. Am J Pathol. 1998 Aug;153(2):457-67
(Latest) J:198352 Shi G, et al., Platelet factor 4 mediates vascular smooth muscle cell injury responses. Blood. 2013 May 23;121(21):4417-27
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory