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Pf4
Gene Detail
Symbol

Name
ID
Pf4
platelet factor 4
MGI:1888711
Synonyms
Cxcl4, Pf4, Scyb4
Feature Type
protein coding gene
Genetic Map
Chromosome 5
44.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:90772435-90773381 bp, + strand
From Ensembl annotation of GRCm38

  947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87791  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: PF4
Protein SuperFamily: CXC chemokine
Gene Tree: Pf4

Human
homologs
PF4, platelet factor 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5196
neXtProt AC: NX_P02776

Human Synonyms: CXCL4, PF-4, SCYB4

Human Chr (Location): 4q12-q21; chr4:73980825-73982124 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous and heterozygous null mice display increased platelet counts and reduced thrombus formation following vascular injury.
 
Interactions
Pf4 interacts with 17 markers (Mir194-1, Mir194-2, Mir322, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cell chemotaxis, chemokine-mediated signaling pathway, ...
Component extracellular region, extracellular space, ...
Function chemokine activity, CXCR3 chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (175)    Tissues (46)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 166
RT-PCR 9
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029373 (Evidence)
Entrez Gene 56744 (Evidence)
UniGene 332490
DFCI TC1767251, TC1581227
DoTS DT.97337465, DT.102519772
NIA Mouse Gene Index U005782
Consensus CDS Project CCDS19416.1
International Mouse Phenotyping Consortium Status Pf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029373 Ensembl Gene Model | MGI Sequence Detail 947 C57BL/6J ±  kb
transcript ENSMUST00000031320 Ensembl | MGI Sequence Detail 586 Not Applicable 
polypeptide ENSMUSP00000031320 Ensembl | MGI Sequence Detail 105 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001811 Chemokine interleukin-8-like domain
InterPro IPR001089 CXC chemokine
InterPro IPR018048 CXC chemokine, conserved site
InterPro IPR027222 Platelet factor 4
Protein Ontology PR:000012569 platelet factor 4
References
(Earliest) J:56215 Watanabe O, et al., Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis. J Hum Genet. 1999;44(3):173-6
(Latest) J:208443 Shi G, et al., Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. J Clin Invest. 2014 Feb 3;124(2):543-52
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory