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St3gal6 Gene Detail
Summary
  • Symbol
    St3gal6
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 6
  • Synonyms
    1700023B24Rik, Siat10, ST3Gal VI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888707
    NCBI Gene: 54613
  • Alliance
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:58469742-58524253 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 34.58 cM, cytoband C1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888707
protein coding gene Chr16:58468125-58524253 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022902
protein coding gene Chr16:57633678-57693749 (-)
A/J MGP_AJ_G0022869
protein coding gene Chr16:55178545-55235518 (-)
AKR/J MGP_AKRJ_G0022841
protein coding gene Chr16:56907477-56967043 (-)
BALB/cJ MGP_BALBcJ_G0022869
protein coding gene Chr16:55270883-55328742 (-)
C3H/HeJ MGP_C3HHeJ_G0022632
protein coding gene Chr16:57125258-57185894 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023317
protein coding gene Chr16:59254509-59317770 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020828
protein coding gene Chr16:54739920-54795828 (-)
CAST/EiJ MGP_CASTEiJ_G0022159
protein coding gene Chr16:57457091-57519023 (-)
CBA/J MGP_CBAJ_G0022605
protein coding gene Chr16:61618029-61680574 (-)
DBA/2J MGP_DBA2J_G0022737
protein coding gene Chr16:54911829-54967766 (-)
FVB/NJ MGP_FVBNJ_G0022712
protein coding gene Chr16:54661583-54717425 (-)
LP/J MGP_LPJ_G0022804
protein coding gene Chr16:57416022-57483379 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022730
protein coding gene Chr16:61977176-62035838 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023332
protein coding gene Chr16:57041222-57098902 (-)
PWK/PhJ MGP_PWKPhJ_G0021898
protein coding gene Chr16:55215079-55271608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021728
protein coding gene Chr16:56817106-56873820 (-)
WSB/EiJ MGP_WSBEiJ_G0022203
protein coding gene Chr16:57079468-57135096 (-)



Homology
more
  • Human Ortholog
    ST3GAL6, ST3 beta-galactoside alpha-2,3-sialyltransferase 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ST3GAL6, ST3 beta-galactoside alpha-2,3-sialyltransferase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAT10, ST3GALVI
  • Links
    NCBI Gene ID: 10402
    neXtProt AC: NX_Q9Y274
    UniProt: Q9Y274

  • Chr Location
    3q12.1; chr3:98732236-98795845 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit modest impairment in leukocyte rolling and neutrophil recruitment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54613 NCBI Gene Model | MGI Sequence Detail 54512 C57BL/6J ±  kb
transcript NM_018784 RefSeq | MGI Sequence Detail 2506 C57BL/6  
polypeptide Q8VIB3 UniProt | EBI | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 9
Other
Accession IDs
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MGI:1922763, MGI:2146521, MGI:2146659
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:64092 Kapitonov D, et al., Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. Glycoconj J. 1999 Jul;16(7):337-50
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory