St3gal6
Gene Detail

Symbol Name ID

St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 MGI:1888707

Synonyms

1700023B24Rik, Siat10, ST3Gal VI

Feature Type

protein coding gene

Genetic Map

Chromosome 16

34.58 cM, cytoband C1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:58468125-58524243 bp, - strand From VEGA annotation of GRCm38   56119 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: sialyltransferase
Gene Tree: St3gal6

Human homologs

Human Homolog		ST3GAL6, ST3 beta-galactoside alpha-2,3-sialyltransferase 6
NCBI Gene ID		10402
neXtProt AC		NX_Q9Y274
Human Synonyms		SIAT10, ST3GALVI
Human Chr (Location)		3q12.1; chr3:98451080-98514689 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit modest impairment in leukocyte rolling and neutrophil recruitment.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cellular protein modification process, glycolipid metabolic process, ...
Component	Golgi apparatus, integral to Golgi membrane, ...
Function	beta-galactoside alpha-2,3-sialyltransferase activity, sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (118)    Tissues (109)    Images (2)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	118

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(16)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000025631 (Evidence)
Ensembl Gene Model	ENSMUSG00000022747 (Evidence)
Entrez Gene	54613 (Evidence)
NIA Mouse Gene Index	U037137
EC	2.4.99.-
Consensus CDS Project	CCDS28230.1
International Mouse Knockout Project Status	St3gal6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025631	VEGA Gene Model | MGI Sequence Detail	56119	C57BL/6J
transcript	OTTMUST00000063058	VEGA | MGI Sequence Detail	2264	Not Applicable
polypeptide	OTTMUSP00000031154	VEGA | MGI Sequence Detail	329	Not Applicable

All sequences(78) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(274 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000015683	type 2 lactosamine alpha-2,3-sialyltransferase

References

(Earliest) J:64092 Kapitonov D, et al., Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase. Glycoconj J. 1999 Jul;16(7):337-50
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(36)

Other accession IDs

MGI:1922763, MGI:2146521, MGI:2146659