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Rps27 Gene Detail
Summary
  • Symbol
    Rps27
  • Name
    ribosomal protein S27
  • Synonyms
    3200001M24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888676
    NCBI Gene: 57294
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90119974-90120955 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888676
 protein coding gene Chr3:90119829-90120958 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J ENSMUSG00220046356
 protein coding gene Chr3:86944847-86945976 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0025226
 protein coding gene Chr3:82992311-82993436 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J ENSMUSG00185052192
 protein coding gene Chr3:87170114-87171850 (-)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000046423
 protein coding gene Chr3:86783186-86784315 (-)
LP/J ENSMUSG00230034227
 protein coding gene Chr3:89196413-89197542 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005045115
 protein coding gene Chr3:87475954-87477082 (-)



Homology
more
  • Human Ortholog
    RPS27, ribosomal protein S27
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS27, ribosomal protein S27
  • Synonyms
    DBA17, eS27, MPS-1, MPS1, S27
  • Links
    NCBI Gene ID: 6232
    UniProt: P42677

  • Chr Location
    1q21.3; chr1:153990749-153992333 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RPS27 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic growth retardation, small egg cylinders, disorganized extraembryonic tissue, failure of primitive streak formation and gastrulation, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    35
  • cDNA Data
    11
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57294 NCBI Gene Model | MGI Sequence Detail 982 C57BL/6J ±  kb
    transcript NR_033727 RefSeq | MGI Sequence Detail 599 C57BL/6  
    polypeptide Q6ZWU9 UniProt | EBI | MGI Sequence Detail 84 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • GlyGen
      Q6ZWU9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916522
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory