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Psmd8 Gene Detail
Summary
  • Symbol
    Psmd8
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
  • Synonyms
    6720456J22Rik, C76433
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888669
    NCBI Gene: 57296
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28873612-28880098 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888669
 protein coding gene Chr7:28873612-28880126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031975
 protein coding gene Chr7:28081582-28088064 (-)
A/J MGP_AJ_G0031953
 protein coding gene Chr7:27338620-27345158 (-)
AKR/J MGP_AKRJ_G0031885
 protein coding gene Chr7:28039899-28047221 (-)
BALB/cJ MGP_BALBcJ_G0031960
 protein coding gene Chr7:27506515-27512920 (-)
C3H/HeJ MGP_C3HHeJ_G0031679
 protein coding gene Chr7:28445732-28452332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032424
 protein coding gene Chr7:28968641-28981242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029476
 protein coding gene Chr7:28399102-28405656 (-)
CAST/EiJ MGP_CASTEiJ_G0031014
 protein coding gene Chr7:21746468-21754761 (-)
CBA/J MGP_CBAJ_G0031645
 protein coding gene Chr7:30319322-30328519 (-)
DBA/2J MGP_DBA2J_G0031797
 protein coding gene Chr7:27078284-27084954 (-)
FVB/NJ MGP_FVBNJ_G0031754
 protein coding gene Chr7:27175495-27182281 (-)
LP/J MGP_LPJ_G0031877
 protein coding gene Chr7:28372839-28380773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031790
 protein coding gene Chr7:29698245-29706358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032454
 protein coding gene Chr7:27533488-27539998 (-)
PWK/PhJ MGP_PWKPhJ_G0030739
 protein coding gene Chr7:22124030-22130589 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030572
 protein coding gene Chr7:18555598-18561876 (-)
WSB/EiJ MGP_WSBEiJ_G0031123
 protein coding gene Chr7:27901684-27908721 (-)



Homology
more
  • Human Ortholog
    PSMD8, proteasome 26S subunit, non-ATPase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD8, proteasome 26S subunit, non-ATPase 8
  • Synonyms
    HEL-S-91n, HIP6, HYPF, Nin1p, p31, Rpn12, S14
  • Links
    NCBI Gene ID: 5714
    UniProt: P48556

  • Chr Location
    19q13.2; chr19:38374563-38383850 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    8
  • cDNA Data
    312
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 57296 NCBI Gene Model | MGI Sequence Detail 6487 C57BL/6J ±  kb
transcript NM_026545 RefSeq | MGI Sequence Detail 1529 C57BL/6  
polypeptide Q9CX56 UniProt | EBI | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000013390 26S proteasome non-ATPase regulatory subunit 8
    (term hierarchy)
  • InterPro Domains
    IPR006746 26S proteasome non-ATPase regulatory subunit Rpn12
    IPR033464 CSN8/PSMD8/EIF3K
    IPR000717 Proteasome component (PCI) domain
  • GlyGen
    Q9CX56 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 313
    cDNA 313

    Microarray probesets 3
Other
Accession IDs
less
MGI:1353608, MGI:1915322, MGI:2139137, MGI:2141806, MGI:2142104, MGI:2145720
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:310903 Gresakova V, et al., Dual role of Fam208a during zygotic cleavage and early embryonic development. Exp Cell Res. 2021 Sep 15;406(2):112723
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory