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Apba3 Gene Detail
Summary
  • Symbol
    Apba3
  • Name
    amyloid beta (A4) precursor protein-binding, family A, member 3
  • Synonyms
    lin-10, Mint 3, Mint-3, neuronal munc18-1-interacting protein 3, neuron-specific X11L2 protein, X11gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888527
    NCBI Gene: 57267
  • Gene Overview
    MyGene.info: APBA3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:81266965-81273247 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6283 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    APBA3, amyloid beta precursor protein binding family A member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APBA3, amyloid beta precursor protein binding family A member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MGC:15815, mint3, X11L2
  • Links
    NCBI Gene ID: 9546
    neXtProt AC: NX_O96018
    UniProt: O96018

  • Chr Location
    19p13.3; chr19:3750773-3761697 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3591
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APBA3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Deletion in mutants causes abnormalities in colon morphology and physiology, increased circulating blood urea nitrogen, and decreased serum chloride, sodium and potassium levels. Surviving homozygotes display diarrhea, postnatal viability and decreased life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57267 NCBI Gene Model | MGI Sequence Detail 6283 C57BL/6J ±  kb
transcript NM_018758 RefSeq | MGI Sequence Detail 2124 C57BL/6  
polypeptide O88888 UniProt | EBI | MGI Sequence Detail 571 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 51
    cDNA 51

    Microarray probesets 3
Other
Accession IDs
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MGI:2143823
References
more
  • Summaries
    All 46
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:250868 Hara T, et al., Mint3 in bone marrow-derived cells promotes lung metastasis in breast cancer model mice. Biochem Biophys Res Commun. 2017 Aug 26;490(3):688-692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory