About   Help   FAQ
Xpo4 Gene Detail
Summary
  • Symbol
    Xpo4
  • Name
    exportin 4
  • Synonyms
    B430309A01Rik, mKIAA1721
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888526
    NCBI Gene: 57258
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:57814978-57902887 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.11 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1493 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888526
 protein coding gene Chr14:57814978-57906951 (-)
129S1/SvImJ ENSMUSG00200040268
 protein coding gene Chr14:46400240-46488157 (-)
A/J ENSMUSG00195028136
 protein coding gene Chr14:46615499-46703416 (-)
AKR/J ENSMUSG00220026984
 protein coding gene Chr14:45942456-46030370 (-)
BALB/cJ ENSMUSG00180047557
 protein coding gene Chr14:46237521-46325450 (-)
C3H/HeJ ENSMUSG00175047991
 protein coding gene Chr14:47944051-48031968 (-)
C57BL/6NJ ENSMUSG00215046380
 protein coding gene Chr14:46138193-46226107 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019352
 protein coding gene Chr14:48826965-48911914 (-)
CAST/EiJ ENSTCUG00005047350
 protein coding gene Chr14:47916226-48003050 (-)
CBA/J ENSMUSG00210043282
 protein coding gene Chr14:46605871-46693787 (-)
DBA/2J ENSMUSG00185031394
 protein coding gene Chr14:51737838-51825804 (-)
FVB/NJ ENSMUSG00205040788
 protein coding gene Chr14:46007886-46095813 (-)
JF1/MsJ ENSUMUG00000032786
 protein coding gene Chr14:62909112-62995351 (-)
LP/J ENSMUSG00230033679
 protein coding gene Chr14:63769229-63857142 (-)
NOD/ShiLtJ ENSMUSG00190034345
 protein coding gene Chr14:46372192-46460103 (-)
NZO/HlLtJ ENSMUSG00225044012
 protein coding gene Chr14:54062539-54150451 (-)
PWK/PhJ ENSLUMG00010041305
 protein coding gene Chr14:45831830-45919767 (-)
SPRET/EiJ ENSMSPG00010039840
 protein coding gene Chr14:49351077-49437965 (-)
WSB/EiJ ENSIUOG00005040507
 protein coding gene Chr14:45798789-45886724 (-)



Homology
more
  • Human Ortholog
    XPO4, exportin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XPO4, exportin 4
  • Synonyms
    exp4
  • Links
    NCBI Gene ID: 64328
    UniProt: Q9C0E2

  • Chr Location
    13q12.11; chr13:20777329-20903048 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality before E10.5. Heterozygotes show male infertility, increased DNA damage in testes and the hippocampus, decrease in hippocampal neurons and impaired spatial memory. Mice homozygous for a gene trapped allele appear phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    638
  • Tissues
    27
  • cDNA Data
    69
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021952 Ensembl Gene Model | MGI Sequence Detail 87910 C57BL/6J ±  kb
    transcript ENSMUST00000174545 Ensembl | MGI Sequence Detail 8680 Not Applicable  
    polypeptide ENSMUSP00000133280 Ensembl | MGI Sequence Detail 1151 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 69

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925792
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:63907 Lipowsky G, et al., Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J. 2000 Aug 15;19(16):4362-71
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory