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Tob2 Gene Detail
Summary
  • Symbol
    Tob2
  • Name
    transducer of ERBB2, 2
  • Synonyms
    2900090N22Rik, 4930545K18Rik, mKIAA1663
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888525
    NCBI Gene: 57259
  • Gene Overview
    MyGene.info: TOB2
Location & Maps
more
  • Sequence Map
    Chr15:81848270-81858326 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10057 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 38.26 cM, cytoband E2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TOB2, transducer of ERBB2, 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TOB2, transducer of ERBB2, 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APRO5, TOB4, TOBL, TROB2
  • Links
    NCBI Gene ID: 10766
    neXtProt AC: NX_Q14106

  • Chr Location
    22q13.2; chr22:41433488-41448230 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Tob2
  • Incidental Mutations
Mice homozygous for a targeted mutation display reduced bone mass due to increased osteoclast numbers and acceleration of the bone resorption rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57259 NCBI Gene Model | MGI Sequence Detail 10057 C57BL/6J ±  kb
transcript NM_020507 RefSeq | MGI Sequence Detail 3994 C57BL/6  
polypeptide Q9JM55 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 106
    cDNA 106

    Microarray probesets 8
Other
Accession IDs
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MGI:1920339, MGI:1925282, MGI:2146166
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 27
  • Earliest
    J:63909 Ajima R, et al., Cloning and characterization of the mouse tob2 gene. Gene. 2000 Aug 8;253(2):215-20
  • Latest
    J:228465 Chen Y, et al., BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. Biochem Biophys Res Commun. 2015 Jul 3;462(3):208-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory