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Tob2
Gene Detail
Symbol

Name
ID
Tob2
transducer of ERBB2, 2
MGI:1888525
Synonyms
2900090N22Rik, 4930545K18Rik, mKIAA1663
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.26 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:81848270-81858326 bp, - strand
From NCBI annotation of GRCm38

  10057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TOB2
Protein SuperFamily: Transducer of erbB-2
Gene Tree: Tob2

Human
homologs
TOB2, transducer of ERBB2, 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10766
neXtProt AC: NX_Q14106

Human Synonyms: TOB4, TOBL, TROB2

Human Chr (Location): 22q13.2; chr22:41433488-41448230 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Radiation induced(1) Targeted(4)
Genomic Mutations involving Tob2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display reduced bone mass due to increased osteoclast numbers and acceleration of the bone resorption rate.
 
Phenotype Images(2)
Interactions
Tob2 interacts with 355 markers (Mir1b, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process negative regulation of osteoclast differentiation, positive regulation of ossification, ...
Function vitamin D receptor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (12)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
Northern blot 8
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tob2    NEW 
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000048546 (Evidence)
Entrez Gene 57259 (Evidence)
UniGene 323595
DoTS DT.110790270, DT.94224640, DT.492091, DT.97374493
NIA Mouse Gene Index U036439
Consensus CDS Project CCDS27673.1
International Mouse Phenotyping Consortium Status Tob2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57259 NCBI Gene Model | MGI Sequence Detail 10057 C57BL/6J ±  kb
transcript NM_020507 RefSeq | MGI Sequence Detail 3994 C57BL/6 
polypeptide Q9JM55 UniProt | EBI | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002087 Anti-proliferative protein
InterPro IPR009818 Ataxin-2, C-terminal
InterPro IPR015676 Tob
InterPro IPR015678 Tob2
Protein Ontology PR:000016526 protein Tob2
Graphical View of Protein Domain Structure
References
(Earliest) J:63909 Ajima R, et al., Cloning and characterization of the mouse tob2 gene. Gene. 2000 Aug 8;253(2):215-20
(Latest) J:198582 Gamez B, et al., MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability. J Biol Chem. 2013 May 17;288(20):14264-75
All references(34)
Other
accession IDs
MGI:1920339, MGI:1925282, MGI:2146166

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory