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Brd4
Gene Detail
Symbol

Name
ID
Brd4
bromodomain containing 4
MGI:1888520
Synonyms
HUNK1, MCAP, WI-11513
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.39 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:32196274-32284722 bp, - strand
From VEGA annotation of GRCm38

  88449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136213  Vertebrate Homology Class
1 mouse; 1 western clawed frog

HCOP human homology predictions: BRD4
Gene Tree: Brd4

Human
homologs
BRD4, bromodomain containing 4
Orthology source: HGNC

IDs:
NCBI Gene ID: 23476
neXtProt AC: NX_O60885

Human Synonyms: CAP, HUNK1, HUNKI, MCAP

Human Chr (Location): 19p13.1; chr19:15236836-15332543 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(163) : Gene trapped(162) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a gene-trap null mutation die soon after implantation. Heterozygotes exhibit impaired pre- and postnatal growth, head malformations, lack of subcutaneous fat, cataracts, and abnormal liver cells.
 
Interactions
Brd4 interacts with 341 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process chromatin modification, chromosome segregation, ...
Component chromosome, condensed nuclear chromosome, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (65)    Tissues (59)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
RT-PCR 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase brd4 ; ZFIN brd4    NEW 
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(14) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000030241 (Evidence)
Ensembl Gene Model ENSMUSG00000024002 (Evidence)
Entrez Gene 57261 (Evidence)
DoTS DT.94246093, DT.94209567, DT.101719322, DT.493609, DT.110511671, DT.97414652, DT.97357501
PDB 3MUK, 3JVM, 3JVL, 3JVK, 2DWW, 3JVJ, 2JNS, 3MUL
Consensus CDS Project CCDS37554.1, CCDS50057.1, CCDS70784.1
International Mouse Phenotyping Consortium Status Brd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030241 VEGA Gene Model | MGI Sequence Detail 88449 C57BL/6J ±  kb
transcript OTTMUST00000074873 VEGA | MGI Sequence Detail 5954 Not Applicable 
polypeptide OTTMUSP00000039145 VEGA | MGI Sequence Detail 1400 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(32) UniProt(11)
Polymorphisms
SNPs within 2kb(412 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR027353 NET domain
Protein Ontology PR:000004807 bromodomain-containing protein 4
References
(Earliest) J:50546 Resch K, et al., Homology between human chromosome 2p13.3 and the wobbler critical region on mouse chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs. Mamm Genome. 1998 Nov;9(11):893-8
(Latest) J:218548 Bolden JE, et al., Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell Rep. 2014 Sep 25;8(6):1919-29
All references(50)
Other
accession IDs
MGI:1337084

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory