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Brd4 Gene Detail
Summary
  • Symbol
    Brd4
  • Name
    bromodomain containing 4
  • Synonyms
    HUNK1, MCAP, WI-11513
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888520
    NCBI Gene: 57261
  • Gene Overview
    MyGene.info: BRD4
Location & Maps
more
  • Sequence Map
    Chr17:32196274-32284722 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      88449 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.39 cM, cytoband B2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    BRD4, bromodomain containing 4
  • Vertebrate Orthologs
    2
  • Human Ortholog
    BRD4, bromodomain containing 4
    Orthology source: HGNC
  • Synonyms
    CAP, HUNK1, HUNKI, MCAP
  • Links
    NCBI Gene ID: 23476
    neXtProt AC: NX_O60885

  • Chr Location
    19p13.12; chr19:15236836-15332543 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene-trap null mutation die soon after implantation. Heterozygotes exhibit impaired pre- and postnatal growth, head malformations, lack of subcutaneous fat, cataracts, and abnormal liver cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030241 VEGA Gene Model | MGI Sequence Detail 88449 C57BL/6J ±  kb
transcript OTTMUST00000074872 VEGA | MGI Sequence Detail 5922 Not Applicable  
polypeptide OTTMUSP00000039144 VEGA | MGI Sequence Detail 1400 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    410 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    Genomic 2
    cDNA 14
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1337084
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:50546 Resch K, et al., Homology between human chromosome 2p13.3 and the wobbler critical region on mouse chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs. Mamm Genome. 1998 Nov;9(11):893-8
  • Latest
    J:226248 Korb E, et al., BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice. Nat Neurosci. 2015 Oct;18(10):1464-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory