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Vav3
Gene Detail
Symbol

Name
ID
Vav3
vav 3 oncogene
MGI:1888518
Synonyms
A530094I06Rik, Idd18.1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
48.13 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:109340653-109685698 bp, + strand
From VEGA annotation of GRCm38

  345046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VAV3
Protein SuperFamily: vav transforming protein
Gene Tree: Vav3

Human
homologs
VAV3, vav 3 guanine nucleotide exchange factor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10451
neXtProt AC: NX_Q9UKW4

Human Chr (Location): 1p13.3; chr1:107571160-107964923 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) QTL(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in tachycardia, systemic arterial hypertension, cardiovascular remodeling, hyperactivity of sympathetic neurons and thus high catecholamine levels, and increased levels of kidney-related hormones.
 
Phenotype Images(3)
Interactions
Vav3 interacts with 329 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process angiogenesis, B cell receptor signaling pathway, ...
Component cytoplasm, extracellular exosome, ...
Function epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (434)    Tissues (97)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 434
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA VAV3 ; Xenbase vav3    NEW 
Molecular
reagents
All nucleic(34) cDNA(34)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000007363 (Evidence)
Ensembl Gene Model ENSMUSG00000033721 (Evidence)
Entrez Gene 57257 (Evidence)
UniGene 282257
DFCI TC1581127, TC1590374, TC1611897
DoTS DT.101162917, DT.40182591, DT.87059674, DT.97358422
NIA Mouse Gene Index U003749
Consensus CDS Project CCDS17773.1, CCDS59650.1
International Mouse Phenotyping Consortium Status Vav3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007363 VEGA Gene Model | MGI Sequence Detail 345046 C57BL/6J ±  kb
transcript OTTMUST00000017035 VEGA | MGI Sequence Detail 5019 Not Applicable 
polypeptide OTTMUSP00000007869 VEGA | MGI Sequence Detail 847 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(2853 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2861)
Protein-related
information
ResourceIDDescription
InterPro IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
InterPro IPR028530 Protein vav
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR003096 Smooth muscle protein/calponin
InterPro IPR011511 Variant SH3 domain
Protein Ontology PR:000017267 guanine nucleotide exchange factor VAV3
References
(Earliest) J:63932 Moores SL, et al., Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000 Sep;20(17):6364-73
(Latest) J:221504 Pan D, et al., P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015 Feb 12;125(7):1146-58
All references(84)
Other
accession IDs
MGI:2139612, MGI:2444834, MGI:5288360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory