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Vav3
Gene Detail
 Symbol
Name
ID
Vav3
vav 3 oncogene
MGI:1888518
Synonyms A530094I06Rik, Idd18.1
Feature Type protein coding gene
Genetic Map
Chromosome 3
48.13 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:109340653-109685698 bp, + strand
From VEGA annotation of GRCm38

  345046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vav transforming protein
Gene Tree: Vav3

Human
homologs
Human Homolog VAV3, vav 3 guanine nucleotide exchange factor
NCBI Gene ID 10451
neXtProt AC  NX_Q9UKW4
Human Chr (Location)  1p13.3; chr1:107571160-107964923 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(2) QTL(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in tachycardia, systemic arterial hypertension, cardiovascular remodeling, hyperactivity of sympathetic neurons and thus high catecholamine levels, and increased levels of kidney-related hormones.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process angiogenesis, B cell receptor signaling pathway, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (434)    Tissues (97)    Images (25)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 434
cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) cDNA(34)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000007363 (Evidence)
Ensembl Gene ModelENSMUSG00000033721 (Evidence)
Entrez Gene57257 (Evidence)
UniGene282257
DFCITC1581127, TC1590374, TC1611897
DoTSDT.101162917, DT.40182591, DT.87059674, DT.97358422
NIA Mouse Gene IndexU003749
Consensus CDS ProjectCCDS17773.1, CCDS59650.1
International Mouse Knockout Project StatusVav3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007363 VEGA Gene Model | MGI Sequence Detail 345046 C57BL/6J ±  kb
transcript OTTMUST00000017035 VEGA | MGI Sequence Detail 5019 Not Applicable 
polypeptide OTTMUSP00000007869 VEGA | MGI Sequence Detail 847 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(2853 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2861)
Protein-related
information
ResourceIDDescription
InterPro IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR003096 Smooth muscle protein/calponin
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000017267 guanine nucleotide exchange factor VAV3
References (Earliest) J:63932 Moores SL, et al., Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000 Sep;20(17):6364-73
(Latest) J:209098 Gmyrek GB, et al., Loss of DAP12 and FcRgamma drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. PLoS One. 2013;8(10):e76145
All references(83)
Other
accession IDs
MGI:2139612, MGI:2444834, MGI:5288360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory