Retn
Gene Detail

Symbol Name ID

Retn resistin MGI:1888506

Synonyms

adipocyte-specific secretory factor, ADSF, Fizz3, rstn, Xcp4

Feature Type

protein coding gene

Genetic Map

Chromosome 8

1.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:3655770-3660110 bp, + strand From VEGA annotation of GRCm38   4341 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Retn

Human homologs

Human Homolog		RETN, resistin
NCBI Gene ID		56729
neXtProt AC		NX_Q9HD89
Human Synonyms		ADSF, FIZZ3, RETN1, RSTN, XCP1
Human Chr (Location)		19p13.2; chr19:7733972-7735340 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RETN

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous null mice display impaired gluconeogenesis, lower fasting blood glucose levels, and a weaker positive correlation between body weight and blood glucose.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	fat cell differentiation, negative regulation of feeding behavior, ...
Component	extracellular region, extracellular space, ...
Function	hormone activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (2)    Images (4)
Theiler Stages: 28

Assay Type	Results
Northern blot	6
RT-PCR	2

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(1) cDNA(50) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030662 (Evidence)
Ensembl Gene Model	ENSMUSG00000012705 (Evidence)
Entrez Gene	57264 (Evidence)
UniGene	1181
DFCI	TC1581224
DoTS	DT.101229144, DT.493422
NIA Mouse Gene Index	U009029
PDB	1RFX, 1RGX
Consensus CDS Project	CCDS22068.1
International Mouse Knockout Project Status	Retn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030662	VEGA Gene Model | MGI Sequence Detail	4341	C57BL/6J
transcript	OTTMUST00000075911	VEGA | MGI Sequence Detail	874	Not Applicable
polypeptide	OTTMUSP00000039872	VEGA | MGI Sequence Detail	114	Not Applicable

All sequences(29) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009714	Resistin
Protein Ontology	PR:000013896	resistin

References

(Earliest) J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
(Latest) J:188330 Benezech C, et al., Lymphotoxin-beta Receptor Signaling through NF-kappaB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells. Immunity. 2012 Oct 19;37(4):721-34
All references(53)