Retn MGI Mouse Gene Detail - MGI:1888506

Symbol

Retn
Name

resistin
Synonyms

adipocyte-specific secretory factor, ADSF, Fizz3, rstn, Xcp4

Feature Type

protein coding gene
IDs

MGI:1888506
NCBI Gene: 57264
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:3705770-3709818 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 1.92 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888506	protein coding gene	Chr8:3705770-3710110 (+)
129S1/SvImJ	ENSMUSG00200012011	protein coding gene	Chr8:526663-531035 (+)
A/J	ENSMUSG00195010100	protein coding gene	Chr8:931035-935376 (+)
AKR/J	ENSMUSG00220010278	protein coding gene	Chr8:657560-661900 (+)
BALB/cJ	ENSMUSG00180004018	protein coding gene	Chr8:581510-585849 (+)
C3H/HeJ	ENSMUSG00175007711	protein coding gene	Chr8:696121-700461 (+)
C57BL/6NJ	ENSMUSG00215005158	protein coding gene	Chr8:610475-614815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030779	protein coding gene	Chr8:524235-528356 (+)
CAST/EiJ	ENSTCUG00005020224	protein coding gene	Chr8:668294-672654 (+)
CBA/J	ENSMUSG00210010577	protein coding gene	Chr8:573695-578035 (+)
DBA/2J	ENSMUSG00185003527	protein coding gene	Chr8:709740-714080 (+)
FVB/NJ	ENSMUSG00205005461	protein coding gene	Chr8:643568-647908 (+)
JF1/MsJ	ENSUMUG00000021474	protein coding gene	Chr8:663310-667682 (+)
LP/J	ENSMUSG00230006250	protein coding gene	Chr8:2879331-2883671 (+)
NOD/ShiLtJ	ENSMUSG00190010439	protein coding gene	Chr8:683756-688096 (+)
NZO/HlLtJ	ENSMUSG00225016566	protein coding gene	Chr8:10744574-10748931 (+)
PWK/PhJ	ENSLUMG00010009583	protein coding gene	Chr8:620608-624964 (+)
SPRET/EiJ	ENSMSPG00010015701	protein coding gene	Chr8:588215-590525 (+)
WSB/EiJ	ENSIUOG00005004396	protein coding gene	Chr8:618211-622566 (+)

Human Ortholog

RETN, resistin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RETN, resistin
Synonyms

ADSF, FIZZ3, RENT, RETN1, RSTN, XCP1
Links

HGNC:20389

NCBI Gene ID: 56729

UniProt: Q9HD89
Chr Location

19p13.2; chr19:7669049-7670455 (+) GRCh38

MGI Vertebrate Homology

Retn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RETN
Gene Tree

Retn

Diseases

5 with human RETN associations

				Human Disease	Mouse Models
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				stroke IDs stroke DOID:0051061
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Gene trapped

1
Targeted

5
Transgenic

1
Incidental Mutations

CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice display impaired gluconeogenesis, lower fasting blood glucose levels, and a weaker positive correlation between body weight and blood glucose.

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All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

612
Tissues

6
cDNA Data

45
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase retn

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All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS22068.1

Ensembl

ENSMUSG00000012705 (Evidence)
NCBI Gene

57264

			Length	Strain/Species	Flank
genomic	57264	NCBI Gene Model \| MGI Sequence Detail	4049	C57BL/6J	± kb
transcript	NM_022984	RefSeq \| MGI Sequence Detail	1139	ZRU/MplStud
polypeptide	Q99P87	UniProt \| EBI \| MGI Sequence Detail	114	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013896 resistin

(term hierarchy)
PDB

1RFX, 1RGX
InterPro Domains

IPR009714 Resistin-like molecule hormone family

IPR036262 Resistin-like superfamily

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All nucleic 50

Genomic 1

cDNA 46

Primer pair 2

Other 1

Microarray probesets 4

Summaries

All 106

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 22
Earliest

J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
Latest

J:363294 Wang S, et al., SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2025 Mar;32(3):447-465

TSS for Retn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76081	Chr8:3705762-3705781 (+)	2 bp
Tssr76082	Chr8:3705802-3705813 (+)	38 bp
Tssr76083	Chr8:3709767-3709769 (+)	3,998 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24