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Retn
Gene Detail
Symbol

Name
ID
Retn
resistin
MGI:1888506
Synonyms
adipocyte-specific secretory factor, ADSF, Fizz3, rstn, Xcp4
Feature Type
protein coding gene
Genetic Map
Chromosome 8
1.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:3655770-3660110 bp, + strand
From VEGA annotation of GRCm38

  4341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

HCOP human homology predictions: RETN
Gene Tree: Retn

Human
homologs
RETN, resistin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 56729
neXtProt AC: NX_Q9HD89

Human Synonyms: ADSF, FIZZ3, RETN1, RSTN, XCP1

Human Chr (Location): 19p13.2; chr19:7669086-7670454 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RETN

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from CvDC )
 
Homozygous null mice display impaired gluconeogenesis, lower fasting blood glucose levels, and a weaker positive correlation between body weight and blood glucose.
 
Interactions
Retn interacts with 113 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process fat cell differentiation, negative regulation of feeding behavior, ...
Component extracellular exosome, extracellular region, ...
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (8)    Tissues (2)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 6
RT-PCR 2
cDNA source data(44)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(45) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030662 (Evidence)
Ensembl Gene Model ENSMUSG00000012705 (Evidence)
Entrez Gene 57264 (Evidence)
UniGene 1181
DFCI TC1581224
DoTS DT.101229144, DT.493422
NIA Mouse Gene Index U009029
PDB 1RFX, 1RGX
Consensus CDS Project CCDS22068.1
International Mouse Phenotyping Consortium Status Retn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030662 VEGA Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
transcript OTTMUST00000075911 VEGA | MGI Sequence Detail 874 Not Applicable 
polypeptide OTTMUSP00000039872 VEGA | MGI Sequence Detail 114 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009714 Resistin
Protein Ontology PR:000013896 resistin
References
(Earliest) J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
(Latest) J:213153 Harms MJ, et al., Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory