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Retn Gene Detail
Summary
  • Symbol
    Retn
  • Name
    resistin
  • Synonyms
    adipocyte-specific secretory factor, ADSF, Fizz3, rstn, Xcp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888506
    NCBI Gene: 57264
  • Gene Overview
    MyGene.info: RETN
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RETN, resistin
  • Vertebrate Orthologs
    5
  • Human Ortholog
    RETN, resistin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADSF, FIZZ3, RETN1, RSTN, XCP1
  • Links
    NCBI Gene ID: 56729
    neXtProt AC: NX_Q9HD89
    UniProt: Q9HD89

  • Chr Location
    19p13.2; chr19:7669086-7670454 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RETN associations

Human Disease Mouse Models
      
IDs
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired gluconeogenesis, lower fasting blood glucose levels, and a weaker positive correlation between body weight and blood glucose.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030662 VEGA Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
    transcript OTTMUST00000075911 VEGA | MGI Sequence Detail 874 Not Applicable  
    polypeptide OTTMUSP00000039872 VEGA | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      43 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 1
      cDNA 45
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
    • Latest
      J:232945 Razvi SS, et al., Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1174-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory