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Retn
Gene Detail
 Symbol
Name
ID
Retn
resistin
MGI:1888506
Synonyms adipocyte-specific secretory factor, ADSF, Fizz3, rstn, Xcp4
Feature Type protein coding gene
Genetic Map
Chromosome 8
1.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:3655770-3660110 bp, + strand
From VEGA annotation of GRCm38

  4341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10703  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Gene Tree: Retn

Human
homologs
Human Homolog RETN, resistin
NCBI Gene ID 56729
neXtProt AC  NX_Q9HD89
Human Synonyms  ADSF, FIZZ3, RETN1, RSTN, XCP1
Human Chr (Location)  19p13.2; chr19:7669086-7670454 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RETN
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
 
Homozygous null mice display impaired gluconeogenesis, lower fasting blood glucose levels, and a weaker positive correlation between body weight and blood glucose.
 
Interactions
Retn interacts with 113 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process fat cell differentiation, negative regulation of feeding behavior, ...
Component extracellular region, extracellular space, ...
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (2)    Images (4)
Theiler Stages: 28
Assay TypeResults
Northern blot 6
RT-PCR 2
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(1) cDNA(45) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030662 (Evidence)
Ensembl Gene ModelENSMUSG00000012705 (Evidence)
Entrez Gene57264 (Evidence)
UniGene1181
DFCITC1581224
DoTSDT.101229144, DT.493422
NIA Mouse Gene IndexU009029
PDB1RFX, 1RGX
Consensus CDS ProjectCCDS22068.1
International Mouse Knockout Project StatusRetn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030662 VEGA Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
transcript OTTMUST00000075911 VEGA | MGI Sequence Detail 874 Not Applicable 
polypeptide OTTMUSP00000039872 VEGA | MGI Sequence Detail 114 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009714 Resistin
Protein Ontology PR:000013896 resistin
References (Earliest) J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
(Latest) J:210884 Asterholm IW, et al., Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014 Jun;57(6):1209-18
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory