About   Help   FAQ
Retnlb Gene Detail
Summary
  • Symbol
    Retnlb
  • Name
    resistin like beta
  • Synonyms
    9030012B21Rik, Fizz2, Relmb, RELMbeta, Xcp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888505
    NCBI Gene: 57263
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48816856-48818892 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 30.75 cM, cytoband B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888505
protein coding gene Chr16:48816856-48818892 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022867
protein coding gene Chr16:47696373-47698410 (+)
A/J MGP_AJ_G0022833
protein coding gene Chr16:45596881-45598916 (+)
AKR/J MGP_AKRJ_G0022805
protein coding gene Chr16:47113847-47115882 (+)
BALB/cJ MGP_BALBcJ_G0022834
protein coding gene Chr16:45641327-45643362 (+)
C3H/HeJ MGP_C3HHeJ_G0022597
protein coding gene Chr16:47207677-47209696 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023281
protein coding gene Chr16:48876736-48878771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020794
protein coding gene Chr16:45722805-45724834 (+)
CAST/EiJ MGP_CASTEiJ_G0022123
protein coding gene Chr16:47480000-47482057 (+)
CBA/J MGP_CBAJ_G0022570
protein coding gene Chr16:50803816-50805835 (+)
DBA/2J MGP_DBA2J_G0022701
protein coding gene Chr16:45310476-45312511 (+)
FVB/NJ MGP_FVBNJ_G0022677
protein coding gene Chr16:45204485-45206510 (+)
LP/J MGP_LPJ_G0022769
protein coding gene Chr16:47447663-47449698 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022695
protein coding gene Chr16:50485598-50487633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023296
protein coding gene Chr16:47112149-47114184 (+)
PWK/PhJ MGP_PWKPhJ_G0021863
protein coding gene Chr16:45665055-45667074 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021693
protein coding gene Chr16:47001922-47003962 (+)
WSB/EiJ MGP_WSBEiJ_G0022168
protein coding gene Chr16:47161777-47163801 (+)



Homology
more
  • Human Ortholog
    RETNLB, resistin like beta
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RETNLB, resistin like beta
    Orthology source: HomoloGene
  • Synonyms
    FIZZ1, FIZZ2, HXCP2, RELMb, RELMbeta, RELM-beta, XCP2
  • Links
    NCBI Gene ID: 84666
    neXtProt AC: NX_Q9BQ08
    UniProt: Q9BQ08

  • Chr Location
    3q13.13; chr3:108755639-108757283 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene provides protection from DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57263 NCBI Gene Model | MGI Sequence Detail 2037 C57BL/6J ±  kb
    transcript NM_023881 RefSeq | MGI Sequence Detail 718 C57BL/6  
    polypeptide Q99P86 UniProt | EBI | MGI Sequence Detail 105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 87
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925319
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
    • Latest
      J:250608 Propheter DC, et al., Resistin-like molecule beta is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11027-11033

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory