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Retnla Gene Detail
Summary
  • Symbol
    Retnla
  • Name
    resistin like alpha
  • Synonyms
    1810019L16Rik, Fizz1, Fizz-1, HIMF, RELMa, Xcp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888504
    NCBI Gene: 57262
  • Gene Overview
    MyGene.info: RETNLB
Location & Maps
more
  • Sequence Map
    Chr16:48842552-48844461 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1910 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 30.75 cM, cytoband B5
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RETNLB, resistin like beta
  • Vertebrate Orthologs
    2
  • Human Ortholog
    RETNLB, resistin like beta
    Orthology source: HGNC
  • Synonyms
    FIZZ1, FIZZ2, HXCP2, RELMb, RELMbeta, RELM-beta, XCP2
  • Links
    NCBI Gene ID: 84666
    neXtProt AC: NX_Q9BQ08

  • Chr Location
    3q13.1; chr3:108755639-108757283 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 3 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
Homozygous null mice have decreased circulating levels of leptin and are resistant to an induced form of colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57262 NCBI Gene Model | MGI Sequence Detail 1910 C57BL/6J ±  kb
transcript NM_020509 RefSeq | MGI Sequence Detail 598 C57BL/6  
polypeptide Q9EP95 UniProt | EBI | MGI Sequence Detail 111 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    30 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916325
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
  • Latest
    J:233806 IghmPark SH, et al., The Effects of Antigen-Specific IgG1 Antibody for the Pulmonary-Hypertension-Phenotype and B Cells for Inflammation in Mice Exposed to Antigen and Fine Particles from Air Pollution. PLoS One. 2015;10(6):e0129910

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory