Retnla MGI Mouse Gene Detail - MGI:1888504

Symbol

Retnla
Name

resistin like alpha
Synonyms

1810019L16Rik, Fizz1, Fizz-1, HIMF, RELMa, Xcp2

Feature Type

protein coding gene
IDs

MGI:1888504
NCBI Gene: 57262
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr16:48662972-48664824 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.75 cM, cytoband B5
Mapping Data

4 experiments

SNPs within 2kb

30 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888504	protein coding gene	Chr16:48662914-48664824 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022868	protein coding gene	Chr16:47724884-47726793 (+)
A/J	MGP_AJ_G0022834	protein coding gene	Chr16:45629574-45631483 (+)
AKR/J	MGP_AKRJ_G0022806	protein coding gene	Chr16:47144454-47146363 (+)
BALB/cJ	MGP_BALBcJ_G0022835	protein coding gene	Chr16:45667412-45669321 (+)
C3H/HeJ	MGP_C3HHeJ_G0022598	protein coding gene	Chr16:47233040-47234950 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023282	protein coding gene	Chr16:48912016-48913925 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020795	protein coding gene	Chr16:45748368-45750099 (+)
CAST/EiJ	MGP_CASTEiJ_G0022124	protein coding gene	Chr16:47511774-47513682 (+)
CBA/J	MGP_CBAJ_G0022571	protein coding gene	Chr16:50837673-50839583 (+)
DBA/2J	MGP_DBA2J_G0022702	protein coding gene	Chr16:45343378-45345287 (+)
FVB/NJ	MGP_FVBNJ_G0022678	protein coding gene	Chr16:45229887-45231796 (+)
LP/J	MGP_LPJ_G0022770	protein coding gene	Chr16:47473713-47475622 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022696	protein coding gene	Chr16:50513871-50516225 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023297	protein coding gene	Chr16:47141386-47143295 (+)
PWK/PhJ	MGP_PWKPhJ_G0021864	protein coding gene	Chr16:45694245-45696150 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021694	protein coding gene	Chr16:47030766-47032673 (+)
WSB/EiJ	MGP_WSBEiJ_G0022169	protein coding gene	Chr16:47195488-47197397 (+)

Human Ortholog

RETNLB, resistin like beta

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RETNLB, resistin like beta
Synonyms

FIZZ1, FIZZ2, HXCP2, RELMb, RELMbeta, RELM-beta, XCP2
Links

HGNC:20388

NCBI Gene ID: 84666

neXtProt AC: NX_Q9BQ08

UniProt: Q9BQ08
Chr Location

3q13.13; chr3:108743424-108757410 (-) GRCh38

MGI Vertebrate Homology

Retnla stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RETNLB
Gene Tree

Retnla

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Phenotype Summary

15 phenotypes from 1 allele in 3 genetic backgrounds
1 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Targeted

6
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice have decreased circulating levels of leptin and are resistant to induced colitis.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

31
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS49864.2

Ensembl

ENSMUSG00000061100 (Evidence)
NCBI Gene

57262

			Length	Strain/Species	Flank
genomic	57262	NCBI Gene Model \| MGI Sequence Detail	1853	C57BL/6J	± kb
transcript	NM_020509	RefSeq \| MGI Sequence Detail	541	ZRU/MplStud
polypeptide	Q9EP95	UniProt \| EBI \| MGI Sequence Detail	111	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014396 resistin-like alpha

(term hierarchy)
InterPro Domains

IPR009714 Resistin-like molecule hormone family

IPR036262 Resistin-like superfamily

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All nucleic 12

cDNA 10

Other 2

Microarray probesets 3

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MGI:1916325

Summaries

All 77

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 26
Earliest

J:63867 Holcomb IN, et al., FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J. 2000 Aug 1;19(15):4046-55
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Retnla:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138680	Chr16:48662840-48662850 (+)	-127 bp
Tssr138681	Chr16:48662894-48662943 (+)	-53 bp
Tssr138682	Chr16:48662971-48662994 (+)	11 bp
Tssr138683	Chr16:48663017-48663024 (+)	49 bp
Tssr138684	Chr16:48663034-48663058 (+)	74 bp
Tssr138685	Chr16:48663082-48663099 (+)	119 bp
Tssr138686	Chr16:48663206-48663218 (+)	240 bp
Tssr138687	Chr16:48663247-48663260 (+)	282 bp
Tssr138688	Chr16:48663906-48663958 (+)	960 bp
Tssr138689	Chr16:48664534-48664546 (+)	1,568 bp
Tssr138690	Chr16:48664592-48664603 (+)	1,626 bp
Tssr138691	Chr16:48664629-48664656 (+)	1,671 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23