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Ltb4r2 Gene Detail
Summary
  • Symbol
    Ltb4r2
  • Name
    leukotriene B4 receptor 2
  • Synonyms
    5830462O07Rik, BLT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888501
    NCBI Gene: 57260
  • Gene Overview
    MyGene.info: LTB4R2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55761428-55765138 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888501
protein coding gene Chr14:55757922-55765138 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021369
protein coding gene Chr14:49803861-49805662 (+)
A/J MGP_AJ_G0021328
protein coding gene Chr14:48814918-48816719 (+)
AKR/J MGP_AKRJ_G0021304
protein coding gene Chr14:50566416-50568217 (+)
BALB/cJ MGP_BALBcJ_G0021332
protein coding gene Chr14:48780882-48782683 (+)
C3H/HeJ MGP_C3HHeJ_G0021112
protein coding gene Chr14:50255984-50257785 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021770
protein coding gene Chr14:52301148-52302949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019317
protein coding gene Chr14:47184002-47185790 (+)
CAST/EiJ MGP_CASTEiJ_G0020631
protein coding gene Chr14:46514369-46516170 (+)
CBA/J MGP_CBAJ_G0021079
protein coding gene Chr14:53864710-53866511 (+)
DBA/2J MGP_DBA2J_G0021200
protein coding gene Chr14:48534811-48536612 (+)
FVB/NJ MGP_FVBNJ_G0021182
protein coding gene Chr14:47982669-47984470 (+)
LP/J MGP_LPJ_G0021274
protein coding gene Chr14:50855974-50857775 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021206
protein coding gene Chr14:53223516-53225317 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021797
protein coding gene Chr14:49748038-49749839 (+)
PWK/PhJ MGP_PWKPhJ_G0020378
protein coding gene Chr14:45068760-45070561 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020206
protein coding gene Chr14:45753734-45755535 (+)
WSB/EiJ MGP_WSBEiJ_G0020684
protein coding gene Chr14:50032405-50034206 (+)



Homology
more
  • Human Ortholog
    LTB4R2, leukotriene B4 receptor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LTB4R2, leukotriene B4 receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BLT2, BLTR2, JULF2, KPG_004, LTB4-R2, LTB4-R 2, NOP9
  • Links
    NCBI Gene ID: 56413
    neXtProt AC: NX_Q9NPC1
    UniProt: Q9NPC1

  • Chr Location
    14q12; chr14:24310151-24312053 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced incidence and severity of autoantibody-induced inflammatory arthritis and decreased susceptibility to IgE antigen-dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040432 Ensembl Gene Model | MGI Sequence Detail 3711 C57BL/6J ±  kb
transcript ENSMUST00000044554 Ensembl | MGI Sequence Detail 1439 Not Applicable  
polypeptide ENSMUSP00000048358 Ensembl | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923327
References
more
  • Summaries
    All 40
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:63822 Yokomizo T, et al., A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders [see comments]. J Exp Med. 2000 Aug 7;192(3):421-32
  • Latest
    J:255725 Iwamoto S, et al., Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. Sci Rep. 2017 Oct 16;7(1):13267

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory