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Ltb4r2 Gene Detail
Summary
  • Symbol
    Ltb4r2
  • Name
    leukotriene B4 receptor 2
  • Synonyms
    5830462O07Rik, BLT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888501
    NCBI Gene: 57260
  • Gene Overview
    MyGene.info: LTB4R2
Location & Maps
more
  • Sequence Map
    Chr14:55761428-55763229 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1802 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM, cytoband C1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LTB4R2, leukotriene B4 receptor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LTB4R2, leukotriene B4 receptor 2
    Orthology source: HomoloGene
  • Synonyms
    BLT2, BLTR2, JULF2, KPG_004, LTB4-R2, LTB4-R 2, NOP9
  • Links
    NCBI Gene ID: 56413
    neXtProt AC: NX_Q9NPC1

  • Chr Location
    14q12; chr14:24310151-24312053 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Ltb4r2
Mice homozygous for a knock-out allele exhibit reduced incidence and severity of autoantibody-induced inflammatory arthritis and decreased susceptibility to IgE antigen-dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040432 Ensembl Gene Model | MGI Sequence Detail 1802 C57BL/6J ±  kb
transcript ENSMUST00000044554 Ensembl | MGI Sequence Detail 1439 Not Applicable  
polypeptide ENSMUSP00000048358 Ensembl | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001595 leukotriene B4 receptor 2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR003981 Leukotriene B4 receptor
    IPR003982 Leukotriene B4 type 2 receptor
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923327
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:63822 Yokomizo T, et al., A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders [see comments]. J Exp Med. 2000 Aug 7;192(3):421-32
  • Latest
    J:213738 Liu M, et al., 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. J Exp Med. 2014 Jun 2;211(6):1063-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory