Gabrq
Gene Detail

Symbol Name ID

Gabrq gamma-aminobutyric acid (GABA) A receptor, subunit theta MGI:1888498

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.29 cM, cytoband A6
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:72825178-72842602 bp, + strand From VEGA annotation of GRCm38   17425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gabrq ± 2 cM)

Gene Tree: Gabrq

Human ortholog

GABRQ gamma-aminobutyric acid (GABA) A receptor, theta NCBI Gene ID 55879
Human Synonyms: THETA
Human ChrX:151806637-151821825 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Males hemizygous for a mutation in this gene exhibit decreased prepulse inhibition.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	chloride transport, gamma-aminobutyric acid signaling pathway, ...
Component	cell junction, chloride channel complex, ...
Function	chloride channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (86)    Tissues (52)    Images (15)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	48
RT-PCR	38

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000017852 (Evidence)
Ensembl Gene Model	ENSMUSG00000031344 (Evidence)
Entrez Gene	57249 (Evidence)
UniGene	117125
DFCI	TC1593486, TC1617403
DoTS	DT.101715019, DT.99852916
NIA Mouse Gene Index	U019927
Consensus CDS Project	CCDS30188.1
International Mouse Knockout Project Status	Gabrq

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017852	VEGA Gene Model | MGI Sequence Detail	17425	C57BL/6J
transcript	OTTMUST00000043205	VEGA | MGI Sequence Detail	2000	Not Applicable
polypeptide	OTTMUSP00000019435	VEGA | MGI Sequence Detail	638	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006028	Gamma-aminobutyric acid A receptor
InterPro	IPR008101	Gamma-aminobutyric-acid A receptor theta subunit
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Protein Ontology	PR:000007781	gamma-aminobutyric acid receptor subunit theta

References

(Earliest) J:62100 Sinkkonen ST, et al., GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J Neurosci. 2000 May 15;20(10):3588-95
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(25)