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Gabrq Gene Detail
Summary
  • Symbol
    Gabrq
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit theta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888498
    NCBI Gene: 57249
  • Gene Overview
    MyGene.info: GABRQ
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72825178-72842602 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.29 cM, cytoband A6
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888498
protein coding gene ChrX:72825163-72842607 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035794
protein coding gene ChrX:68517542-68534905 (+)
A/J MGP_AJ_G0035778
protein coding gene ChrX:68714569-68731965 (+)
AKR/J MGP_AKRJ_G0035700
protein coding gene ChrX:70562812-70580237 (+)
BALB/cJ MGP_BALBcJ_G0035765
protein coding gene ChrX:67749573-67766998 (+)
C3H/HeJ MGP_C3HHeJ_G0035468
protein coding gene ChrX:69016174-69033599 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036295
protein coding gene ChrX:70603684-70621106 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033142
protein coding gene ChrX:67865069-67882458 (+)
CAST/EiJ MGP_CASTEiJ_G0034760
protein coding gene ChrX:54345387-54362774 (+)
CBA/J MGP_CBAJ_G0035443
protein coding gene ChrX:72526949-72544374 (+)
DBA/2J MGP_DBA2J_G0035596
protein coding gene ChrX:68216100-68233525 (+)
FVB/NJ MGP_FVBNJ_G0035547
protein coding gene ChrX:67554343-67571768 (+)
LP/J MGP_LPJ_G0035685
protein coding gene ChrX:69365261-69382685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035582
protein coding gene ChrX:75147550-75164975 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036316
protein coding gene ChrX:68370509-68387942 (+)
PWK/PhJ MGP_PWKPhJ_G0034460
protein coding gene ChrX:52349650-52367196 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034295
protein coding gene ChrX:55286743-55305766 (+)
WSB/EiJ MGP_WSBEiJ_G0034902
protein coding gene ChrX:67682051-67699459 (+)



Homology
more
  • Human Ortholog
    GABRQ, gamma-aminobutyric acid type A receptor theta subunit
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GABRQ, gamma-aminobutyric acid type A receptor theta subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    THETA
  • Links
    NCBI Gene ID: 55879
    neXtProt AC: NX_Q9UN88
    UniProt: Q9UN88

  • Chr Location
    Xq28; chrX:152637895-152659827 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males hemizygous for a mutation in this gene exhibit decreased prepulse inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031344 Ensembl Gene Model | MGI Sequence Detail 17425 C57BL/6J ±  kb
transcript ENSMUST00000033711 Ensembl | MGI Sequence Detail 2000 Not Applicable  
polypeptide ENSMUSP00000033711 Ensembl | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007781 gamma-aminobutyric acid receptor subunit theta
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008101 Gamma-aminobutyric-acid A receptor theta subunit
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:62100 Sinkkonen ST, et al., GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J Neurosci. 2000 May 15;20(10):3588-95
  • Latest
    J:221789 Mo J, et al., Early growth response 1 (Egr-1) directly regulates GABAA receptor alpha2, alpha4, and theta subunits in the hippocampus. J Neurochem. 2015 May;133(4):489-500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory