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Mast1 Gene Detail
Summary
  • Symbol
    Mast1
  • Name
    microtubule associated serine/threonine kinase 1
  • Synonyms
    9430008B02Rik, SAST, SAST170
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861901
    NCBI Gene: 56527
  • Gene Overview
    MyGene.info: MAST1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84911903-84937359 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861901
protein coding gene Chr8:84911853-84946131 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033880
protein coding gene Chr8:85841687-85877658 (-)
A/J MGP_AJ_G0033863
protein coding gene Chr8:82458449-82484018 (-)
AKR/J MGP_AKRJ_G0033789
protein coding gene Chr8:84901290-84937834 (-)
BALB/cJ MGP_BALBcJ_G0033856
protein coding gene Chr8:82585428-82611955 (-)
C3H/HeJ MGP_C3HHeJ_G0033566
protein coding gene Chr8:85525390-85551660 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034376
protein coding gene Chr8:89121310-89152139 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031317
protein coding gene Chr8:76251286-76290414 (-)
CAST/EiJ MGP_CASTEiJ_G0032896
protein coding gene Chr8:84956479-84995520 (-)
CBA/J MGP_CBAJ_G0033542
protein coding gene Chr8:92158954-92192450 (-)
DBA/2J MGP_DBA2J_G0033695
protein coding gene Chr8:82097991-82124563 (-)
FVB/NJ MGP_FVBNJ_G0033643
protein coding gene Chr8:81046080-81075508 (-)
LP/J MGP_LPJ_G0033787
protein coding gene Chr8:85949776-85990476 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033685
protein coding gene Chr8:94718284-94747127 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034393
protein coding gene Chr8:84891584-84917574 (-)
PWK/PhJ MGP_PWKPhJ_G0032600
protein coding gene Chr8:81343943-81380288 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032436
protein coding gene Chr8:83701587-83739659 (-)
WSB/EiJ MGP_WSBEiJ_G0033009
protein coding gene Chr8:85322188-85356885 (-)



Homology
more
  • Human Ortholog
    MAST1, microtubule associated serine/threonine kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAST1, microtubule associated serine/threonine kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SAST
  • Links
    NCBI Gene ID: 22983
    neXtProt AC: NX_Q9Y2H9
    UniProt: Q9Y2H9

  • Chr Location
    19p13.13; chr19:12833931-12874953 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053693 Ensembl Gene Model | MGI Sequence Detail 25457 C57BL/6J ±  kb
transcript ENSMUST00000109741 Ensembl | MGI Sequence Detail 4872 Not Applicable  
polypeptide ENSMUSP00000105363 Ensembl | MGI Sequence Detail 1570 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010195 microtubule-associated serine/threonine-protein kinase 1
  • EC
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR028777 Microtubule-associated serine/threonine-protein kinase 1
    IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
    IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
    IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
    IPR001478 PDZ domain
    IPR036034 PDZ superfamily
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 79
    cDNA 79

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924506
References
more
  • Summaries
    All 58
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 32
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory