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Rbms1 Gene Detail
Summary
  • Symbol
    Rbms1
  • Name
    RNA binding motif, single stranded interacting protein 1
  • Synonyms
    2600014B10Rik, MSSP-1, MSSP-2, MSSP-3, YC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861774
    NCBI Gene: 56878
  • Alliance
    genome feature page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:60580537-60793536 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 34.95 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5414 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861774
 protein coding gene Chr2:60580537-60794224 (-)
129S1/SvImJ ENSMUSG00200002629
 protein coding gene Chr2:57649466-57861953 (-)
A/J ENSMUSG00195004850
 protein coding gene Chr2:57768196-57981220 (-)
AKR/J ENSMUSG00220007283
 protein coding gene Chr2:57870005-58083029 (-)
BALB/cJ ENSMUSG00180019758
 protein coding gene Chr2:57724055-57937056 (-)
C3H/HeJ ENSMUSG00175012506
 protein coding gene Chr2:57792885-58005896 (-)
C57BL/6NJ ENSMUSG00215007574
 protein coding gene Chr2:57777545-57990569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023586
 protein coding gene Chr2:55584328-55800887 (-)
CAST/EiJ ENSTCUG00005022267
 protein coding gene Chr2:57129129-57343082 (-)
CBA/J ENSMUSG00210033296
 protein coding gene Chr2:57812010-58025005 (-)
DBA/2J ENSMUSG00185007584
 protein coding gene Chr2:57667885-57880880 (-)
FVB/NJ ENSMUSG00205016042
 protein coding gene Chr2:57308734-57521772 (-)
JF1/MsJ ENSUMUG00000017201
 protein coding gene Chr2:57364629-57578776 (-)
LP/J ENSMUSG00230001375
 protein coding gene Chr2:59533126-59745574 (-)
NOD/ShiLtJ ENSMUSG00190027717
 protein coding gene Chr2:57757185-57970175 (-)
NZO/HlLtJ ENSMUSG00225000762
 protein coding gene Chr2:67256622-67469609 (-)
PWK/PhJ ENSLUMG00010005430
 protein coding gene Chr2:57536389-57750936 (-)
SPRET/EiJ ENSMSPG00010011599
 protein coding gene Chr2:58688763-58904255 (-)
WSB/EiJ ENSIUOG00005027802
 protein coding gene Chr2:57526120-57933522 (-)



Homology
more
  • Human Ortholog
    RBMS1, RNA binding motif single stranded interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBMS1, RNA binding motif single stranded interacting protein 1
  • Synonyms
    C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1
  • Links
    NCBI Gene ID: 5937
    UniProt: P29558

  • Chr Location
    2q24.2; chr2:160272151-160494100 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Only about half the expected number of mice homozygous for disruptions in this gene are produced in matings of heterozygotes. Embryo sizes are reduced. Females have smaller than normal uteri and decreased levels of progesterone during estrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    95
  • cDNA Data
    24
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026970 Ensembl Gene Model | MGI Sequence Detail 213000 C57BL/6J ±  kb
    transcript ENSMUST00000164147 Ensembl | MGI Sequence Detail 2543 Not Applicable  
    polypeptide ENSMUSP00000131306 Ensembl | MGI Sequence Detail 417 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000013811 RNA-binding motif, single-stranded-interacting protein 1
      (term hierarchy)
    • InterPro Domains
      IPR034404 MSSP-1, RNA recognition motif 1
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR002343 Paraneoplastic encephalomyelitis antigen
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919705, MGI:2138868
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:59635 Fujimoto M, et al., Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein. Int J Oncol. 2000 Feb;16(2):245-51
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory