About   Help   FAQ
Nsmf Gene Detail
Summary
  • Symbol
    Nsmf
  • Name
    NMDA receptor synaptonuclear signaling and neuronal migration factor
  • Synonyms
    Jacob, Nelf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861755
    NCBI Gene: 56876
  • Gene Overview
    MyGene.info: NSMF
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:25054355-25062881 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8527 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NSMF, NMDA receptor synaptonuclear signaling and neuronal migration factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NSMF, NMDA receptor synaptonuclear signaling and neuronal migration factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH9, NELF
  • Links
    NCBI Gene ID: 26012
    neXtProt AC: NX_Q6X4W1
    UniProt: Q6X4W1

  • Chr Location
    9q34.3; chr9:137447570-137459357 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NSMF associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit delayed sexual maturation in female mice with decreased uterus and ovary weights, reduced male and female fertility, and reduced gonadotrophs in female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000011615 VEGA Gene Model | MGI Sequence Detail 8527 C57BL/6J ±  kb
    transcript OTTMUST00000027151 VEGA | MGI Sequence Detail 2957 Not Applicable  
    polypeptide OTTMUSP00000012357 VEGA | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      44 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011136 nasal embryonic luteinizing hormone-releasing hormone factor
    • InterPro Domains
      IPR000048 IQ motif, EF-hand binding site
      IPR033374 NMDA receptor synaptonuclear signalling and neuronal migration factor
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 84
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:63404 Kramer PR, et al., Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons. Genes Dev. 2000 Jul 15;14(14):1824-34
    • Latest
      J:232404 Spilker C, et al., A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genet. 2016 Mar;12(3):e1005907

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory