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Lmbr1 Gene Detail
Summary
  • Symbol
    Lmbr1
  • Name
    limb region 1
  • Synonyms
    1110048D14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861746
    NCBI Gene: 56873
  • Gene Overview
    MyGene.info: LMBR1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:29229802-29378390 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 14.81 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    565 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861746
protein coding gene Chr5:29229802-29378401 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029374
protein coding gene Chr5:27140239-27288758 (-)
A/J MGP_AJ_G0029340
protein coding gene Chr5:26232728-26386390 (-)
AKR/J MGP_AKRJ_G0029291
protein coding gene Chr5:27296534-27452693 (-)
BALB/cJ MGP_BALBcJ_G0029351
protein coding gene Chr5:26777230-26926387 (-)
C3H/HeJ MGP_C3HHeJ_G0029072
protein coding gene Chr5:27328377-27481989 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029804
protein coding gene Chr5:28800553-28961283 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027042
protein coding gene Chr5:23806468-23942761 (-)
CAST/EiJ MGP_CASTEiJ_G0028483
protein coding gene Chr5:26421128-26578718 (-)
CBA/J MGP_CBAJ_G0029040
protein coding gene Chr5:29299054-29488630 (-)
DBA/2J MGP_DBA2J_G0029189
protein coding gene Chr5:26448790-26596130 (-)
FVB/NJ MGP_FVBNJ_G0029147
protein coding gene Chr5:25862075-26003412 (-)
LP/J MGP_LPJ_G0029274
protein coding gene Chr5:27596566-27741380 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029176
protein coding gene Chr5:30308863-30476191 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029838
protein coding gene Chr5:26897529-27041326 (-)
PWK/PhJ MGP_PWKPhJ_G0028207
protein coding gene Chr5:25553026-25699671 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028038
protein coding gene Chr5:26192401-26338175 (-)
WSB/EiJ MGP_WSBEiJ_G0028563
protein coding gene Chr5:26920123-27068891 (-)



Homology
more
  • Human Ortholog
    LMBR1, limb development membrane protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LMBR1, limb development membrane protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACHP, C7orf2, DIF14, LSS, PPD2, THYP, TPT, ZRS
  • Links
    NCBI Gene ID: 64327
    neXtProt AC: NX_Q8WVP7
    UniProt: Q8WVP7

  • Chr Location
    7q36.3; chr7:156673354-156893208 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49706
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LMBR1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lmbr1 mouse models; 3 with human LMBR1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show minor coalitions of distal wrist bones and a low incidence of limb defects, including oligodactyly, brachyphalangia, and soft tissue or bony syndactyly. Homozygotes for another null allele exhibit normal morphology,clinical chemistry, hematology and behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010721 Ensembl Gene Model | MGI Sequence Detail 148589 C57BL/6J ±  kb
    transcript ENSMUST00000055195 Ensembl | MGI Sequence Detail 4926 Not Applicable  
    polypeptide ENSMUSP00000058405 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR008075 Lipocalin-interacting membrane receptor
      IPR006876 LMBR1-like membrane protein
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 9
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1924158, MGI:3034300
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 3
      Phenotypes 44
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:257759 Mouri K, et al., Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1021-1026

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory