Gabarap
Gene Detail

Symbol Name ID

Gabarap gamma-aminobutyric acid receptor associated protein MGI:1861742

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.95 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:69991143-69994951 bp, + strand From VEGA annotation of GRCm38   3809 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 3 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: microtubule-associated proteins 1 light chain 3A/3B
Gene Tree: Gabarap

Human homologs

Human Homolog		GABARAP, GABA(A) receptor-associated protein
NCBI Gene ID		11337
neXtProt AC		NX_O95166
Human Synonyms		ATG8A, GABARAP-a, MM46
Human Chr (Location)		17p13.1; chr17:7143738-7145753 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)
 

Mice homozygous for a disruption in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	apoptotic process, autophagy, ...
Component	actin cytoskeleton, autophagic vacuole, ...
Function	beta-tubulin binding, GABA receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(241)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(241) cDNA(241)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006020 (Evidence)
Ensembl Gene Model	ENSMUSG00000018567 (Evidence)
Entrez Gene	56486 (Evidence)
UniGene	272460
DFCI	TC1573505
Consensus CDS Project	CCDS24928.1
International Mouse Knockout Project Status	Gabarap

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006020	VEGA Gene Model | MGI Sequence Detail	3809	C57BL/6J
transcript	OTTMUST00000013495	VEGA | MGI Sequence Detail	1351	Not Applicable
polypeptide	OTTMUSP00000006254	VEGA | MGI Sequence Detail	117	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004241	Autophagy protein Atg8 ubiquitin-like
Protein Ontology	PR:000007757	gamma-aminobutyric acid receptor-associated protein

References

(Earliest) J:63409 Kneussel M, et al., The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8594-9
(Latest) J:194524 Zhang Z, et al., Gene deletion of gabarap enhances nlrp3 inflammasome-dependent inflammatory responses. J Immunol. 2013 Apr 1;190(7):3517-24
All references(42)