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Gabarap
Gene Detail
Symbol

Name
ID
Gabarap
gamma-aminobutyric acid receptor associated protein
MGI:1861742
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.95 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:69991143-69994951 bp, + strand
From VEGA annotation of GRCm38

  3809 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: GABARAP
Protein SuperFamily: microtubule-associated proteins 1 light chain 3A/3B
Gene Tree: Gabarap

Human
homologs
GABARAP, GABA(A) receptor-associated protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11337
neXtProt AC: NX_O95166

Human Synonyms: ATG8A, GABARAP-a, MM46

Human Chr (Location): 17p13.1; chr17:7240419-7242434 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Genomic Mutations involving Gabarap (1)
 
Mice homozygous for a disruption in this gene display a normal phenotype.
 
Interactions
Gabarap interacts with 126 markers (Mir1a-1, Mir1a-2, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process apoptotic process, autophagosome assembly, ...
Component actin cytoskeleton, autophagosome, ...
Function beta-tubulin binding, GABA receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(241)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gabarapl1 ; ZFIN gabarapa    NEW 
Molecular
reagents
All nucleic(241) cDNA(241)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006020 (Evidence)
Ensembl Gene Model ENSMUSG00000018567 (Evidence)
Entrez Gene 56486 (Evidence)
UniGene 272460
DFCI TC1573505
Consensus CDS Project CCDS24928.1
International Mouse Phenotyping Consortium Status Gabarap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006020 VEGA Gene Model | MGI Sequence Detail 3809 C57BL/6J ±  kb
transcript OTTMUST00000013495 VEGA | MGI Sequence Detail 1351 Not Applicable 
polypeptide OTTMUSP00000006254 VEGA | MGI Sequence Detail 117 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004241 Autophagy protein Atg8 ubiquitin-like
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000007757 gamma-aminobutyric acid receptor-associated protein
References
(Earliest) J:63409 Kneussel M, et al., The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8594-9
(Latest) J:203423 Pampliega O, et al., Functional interaction between autophagy and ciliogenesis. Nature. 2013 Oct 10;502(7470):194-200
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory