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Tmeff2 Gene Detail
Summary
  • Symbol
    Tmeff2
  • Name
    transmembrane protein with EGF-like and two follistatin-like domains 2
  • Synonyms
    4832418D20Rik, 7630402F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861735
    NCBI Gene: 56363
  • Gene Overview
    MyGene.info: TMEFF2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:50927523-51187270 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 25.95 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1899 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861735
protein coding gene Chr1:50900647-51187270 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016001
protein coding gene Chr1:50384269-50685424 (+)
A/J MGP_AJ_G0015983
protein coding gene Chr1:48682662-48971953 (+)
AKR/J MGP_AKRJ_G0015939
protein coding gene Chr1:49708872-50013088 (+)
BALB/cJ MGP_BALBcJ_G0015940
protein coding gene Chr1:48508292-48798547 (+)
C3H/HeJ MGP_C3HHeJ_G0015772
protein coding gene Chr1:50105829-50406028 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016391
protein coding gene Chr1:52518159-52835644 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014133
protein coding gene Chr1:42866218-43140265 (-)
CAST/EiJ MGP_CASTEiJ_G0015353
protein coding gene Chr1:49564444-49871074 (+)
CBA/J MGP_CBAJ_G0015743
protein coding gene Chr1:53902770-54228710 (+)
DBA/2J MGP_DBA2J_G0015844
protein coding gene Chr1:47952390-48242299 (+)
FVB/NJ MGP_FVBNJ_G0015846
protein coding gene Chr1:47406549-47692868 (+)
LP/J MGP_LPJ_G0015915
protein coding gene Chr1:50834264-51142442 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015866
protein coding gene Chr1:56945967-57277032 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016439
protein coding gene Chr1:49830774-50128446 (+)
PWK/PhJ MGP_PWKPhJ_G0015139
protein coding gene Chr1:47809809-48110145 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0015416
protein coding gene Chr1:49639544-49938482 (+)



Homology
more
  • Human Ortholog
    TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT120.2, HPP1, TENB2, TPEF, TR, TR-2
  • Links
    NCBI Gene ID: 23671
    neXtProt AC: NX_Q9UIK5
    UniProt: Q9UIK5

  • Chr Location
    2q32.3; chr2:191948299-192194940 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele display slow postnatal weight gain, decreased white adipose tissue amount, and complete lethality at weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56363 NCBI Gene Model | MGI Sequence Detail 259748 C57BL/6J ±  kb
    transcript NM_019790 RefSeq | MGI Sequence Detail 3339 C57BL/6  
    polypeptide Q9QYM9 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924914, MGI:2444694
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:212490 Chen X, et al., The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. Biochim Biophys Acta. 2014 Jun;1843(6):1216-24

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory