Ccl28 MGI Mouse Gene Detail - MGI:1861731 - C-C motif chemokine ligand 28

Symbol

Ccl28
Name

C-C motif chemokine ligand 28
Synonyms

CCK1, Scya28

Feature Type

protein coding gene
IDs

MGI:1861731
NCBI Gene: 56838
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:120085355-120115895 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, Syntenic
Mapping Data

1 experiment

SNPs within 2kb

296 from dbSNP Build 142
Strain Annotations

17
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861731	protein coding gene	Chr13:120085355-120115895 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020975	protein coding gene	Chr13:122573281-122606629 (+)
A/J	MGP_AJ_G0020925	protein coding gene	Chr13:117704309-117738261 (+)
AKR/J	MGP_AKRJ_G0020900	protein coding gene	Chr13:121163442-121198105 (+)
BALB/cJ	MGP_BALBcJ_G0020925	protein coding gene	Chr13:118272416-118302693 (+)
C3H/HeJ	MGP_C3HHeJ_G0020713	protein coding gene	Chr13:121015754-121054661 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021361	protein coding gene	Chr13:126264045-126294191 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018930	protein coding gene	Chr13:112546823-112576110 (+)
CAST/EiJ	MGP_CASTEiJ_G0020234	protein coding gene	Chr13:120761819-120797573 (+)
CBA/J	MGP_CBAJ_G0020676	protein coding gene	Chr13:130997073-131032595 (+)
DBA/2J	MGP_DBA2J_G0020799	protein coding gene	Chr13:117181336-117211605 (+)
FVB/NJ	MGP_FVBNJ_G0020783	protein coding gene	Chr13:115779205-115811130 (+)
LP/J	MGP_LPJ_G0020876	protein coding gene	Chr13:122641477-122678868 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020809	protein coding gene	Chr13:131778537-131812096 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021396	protein coding gene	Chr13:120788227-120820372 (+)
PWK/PhJ	MGP_PWKPhJ_G0019986	protein coding gene	Chr13:116068497-116099805 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0020292	protein coding gene	Chr13:121383431-121415862 (+)

Human Ortholog

CCL28, C-C motif chemokine ligand 28

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL28, C-C motif chemokine ligand 28
Synonyms

CCK1, MEC, SCYA28
Links

HGNC:17700

NCBI Gene ID: 56477

neXtProt AC: NX_Q9NRJ3

UniProt: Q9NRJ3
Chr Location

5p12; chr5:43356975-43412391 (-) GRCh38

MGI Vertebrate Homology

Ccl28 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCL28
Gene Tree

Ccl28

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Gene trapped

1
Targeted

2
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit a reduction and abnormal distribution of IgA antibody-secreting cells, decreased IgA secretion, increase in Class Bacilli in the gut, and increased susceptibility to induced colitis.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

26

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

6
UniProt

1
CCDS

CCDS56900.1

Ensembl

ENSMUSG00000074715 (Evidence)
NCBI Gene

56838

			Length	Strain/Species	Flank
genomic	56838	NCBI Gene Model \| MGI Sequence Detail	30541	C57BL/6J	± kb
transcript	NM_020279	RefSeq \| MGI Sequence Detail	3753	FVB/N
polypeptide	Q9JIL2	UniProt \| EBI \| MGI Sequence Detail	130	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001803 C-C motif chemokine 28

(term hierarchy)
InterPro Domains

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

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All nucleic 28

cDNA 27

Other 1

Microarray probesets 3

Summaries

All 40

Gene Ontology 7

Phenotypes 10
Earliest

J:63604 Wang W, et al., Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem. 2000 Jul 21;275(29):22313-23
Latest

J:321185 Lin D, et al., Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models. Acta Biochim Biophys Sin (Shanghai). 2020 Jun 20;52(6):691-694

TSS for Ccl28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4188	Chr13:120085332-120085347 (+)	-15 bp
Tssr4189	Chr13:120085362-120085405 (+)	29 bp
Tssr4190	Chr13:120110942-120110981 (+)	25,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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