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Wwp1
Gene Detail
Symbol

Name
ID
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
MGI:1861728
Synonyms
8030445B08Rik, AIP5, SDRP1, Tiul1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
7.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:19608303-19708993 bp, - strand
From VEGA annotation of GRCm38

  100691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: WWP1
Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Wwp1

Human
homologs
WWP1, WW domain containing E3 ubiquitin protein ligase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11059
neXtProt AC: NX_Q9H0M0

Human Synonyms: AIP5, hSDRP1, Tiul1

Human Chr (Location): 8q21; chr8:86342736-86468265 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(42) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased osteoblast differentiation of bone marrow-derived stromal cells.
 
Interactions
Wwp1 interacts with 383 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wwp1    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(26)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000006367 (Evidence)
Ensembl Gene Model ENSMUSG00000041058 (Evidence)
Entrez Gene 107568 (Evidence)
DFCI TC1586635, TC1598234, TC1605573
NIA Mouse Gene Index U004107, U024872, U052495, U060519, U255664
EC 6.3.2.-
Consensus CDS Project CCDS38697.1
International Mouse Phenotyping Consortium Status Wwp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006367 VEGA Gene Model | MGI Sequence Detail 100691 C57BL/6J ±  kb
transcript OTTMUST00000014488 VEGA | MGI Sequence Detail 6440 Not Applicable 
polypeptide OTTMUSP00000006724 VEGA | MGI Sequence Detail 918 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(11) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(458 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT domain
InterPro IPR001202 WW domain
Protein Ontology PR:000003174 NEDD4-like E3 ubiquitin-protein ligase WWP1
References
(Earliest) J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
(Latest) J:190204 Zhao L, et al., Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem Cells. 2011 Oct;29(10):1601-10
All references(35)
Other
accession IDs
MGI:2444949

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory