Wwp1
Gene Detail

Symbol Name ID

Wwp1 WW domain containing E3 ubiquitin protein ligase 1 MGI:1861728

Synonyms

8030445B08Rik, AIP5, SDRP1, Tiul1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

7.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:19608303-19708993 bp, - strand From VEGA annotation of GRCm38   100691 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Wwp1

Human homologs

Human Homolog		WWP1, WW domain containing E3 ubiquitin protein ligase 1
NCBI Gene ID		11059
neXtProt AC		NX_Q9H0M0
Human Synonyms		AIP5, hSDRP1, Tiul1
Human Chr (Location)		8q21; chr8:87354994-87480181 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(43) : Targeted(1) Gene trapped(42)
 

Mice homozygous for a knock-out allele exhibit increased osteoblast differentiation of bone marrow-derived stromal cells.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	lung development, negative regulation of transcription, DNA-dependent, ...
Component	cytoplasm, membrane, ...
Function	ligase activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 19

Assay Type	Results
RNA in situ	2

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(26)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000006367 (Evidence)
Ensembl Gene Model	ENSMUSG00000041058 (Evidence)
Entrez Gene	107568 (Evidence)
DFCI	TC1586635, TC1598234, TC1605573
NIA Mouse Gene Index	U004107, U024872, U052495, U060519, U255664
EC	6.3.2.-
Consensus CDS Project	CCDS38697.1
International Mouse Knockout Project Status	Wwp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006367	VEGA Gene Model | MGI Sequence Detail	100691	C57BL/6J
transcript	OTTMUST00000014488	VEGA | MGI Sequence Detail	6440	Not Applicable
polypeptide	OTTMUSP00000006724	VEGA | MGI Sequence Detail	918	Not Applicable

All sequences(65) RefSeq(7) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(418 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000003174	NEDD4-like E3 ubiquitin-protein ligase WWP1

References

(Earliest) J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
(Latest) J:190204 Zhao L, et al., Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem Cells. 2011 Oct;29(10):1601-10
All references(34)

Other accession IDs

MGI:2444949