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Trpm5 Gene Detail
Summary
  • Symbol
    Trpm5
  • Name
    transient receptor potential cation channel, subfamily M, member 5
  • Synonyms
    9430099A16Rik, Ltrpc5, Mtr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861718
    NCBI Gene: 56843
  • Gene Overview
    MyGene.info: TRPM5
Location & Maps
more
  • Sequence Map
    Chr7:143069153-143094642 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.11 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TRPM5, transient receptor potential cation channel subfamily M member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM5, transient receptor potential cation channel subfamily M member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LTRPC5, MTR1
  • Links
    NCBI Gene ID: 29850
    neXtProt AC: NX_Q9NZQ8

  • Chr Location
    11p15.5; chr11:2403952-2435017 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022683 VEGA Gene Model | MGI Sequence Detail 25490 C57BL/6J ±  kb
transcript OTTMUST00000054375 VEGA | MGI Sequence Detail 4123 Not Applicable  
polypeptide OTTMUSP00000025953 VEGA | MGI Sequence Detail 1158 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016701 transient receptor potential cation channel subfamily M member 5
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR029577 Transient receptor potential cation channel subfamily M member 5
Molecular
Reagents
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  • All nucleic 25
    Genomic 2
    cDNA 16
    Primer pair 7

    Microarray probesets 4
Other
Accession IDs
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MGI:2443185
References
more
  • Summaries
    All 78
    Developmental Gene Expression 12
    Gene Ontology 5
    Phenotypes 34
  • Earliest
    J:63552 Yatsuki H, et al., Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. DNA Res. 2000 Jun 30;7(3):195-206
  • Latest
    J:229827 Shigeto M, et al., GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015 Dec;125(12):4714-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory