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Trpm5 Gene Detail
Summary
  • Symbol
    Trpm5
  • Name
    transient receptor potential cation channel, subfamily M, member 5
  • Synonyms
    9430099A16Rik, Ltrpc5, Mtr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861718
    NCBI Gene: 56843
  • Gene Overview
    MyGene.info: TRPM5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:143069153-143094642 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.11 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TRPM5, transient receptor potential cation channel subfamily M member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM5, transient receptor potential cation channel subfamily M member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LTRPC5, MTR1
  • Links
    NCBI Gene ID: 29850
    neXtProt AC: NX_Q9NZQ8
    UniProt: Q9NZQ8

  • Chr Location
    11p15.5; chr11:2403962-2423424 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022683 VEGA Gene Model | MGI Sequence Detail 25490 C57BL/6J ±  kb
    transcript OTTMUST00000054375 VEGA | MGI Sequence Detail 4123 Not Applicable  
    polypeptide OTTMUSP00000025953 VEGA | MGI Sequence Detail 1158 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      141 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR029577 Transient receptor potential cation channel subfamily M member 5
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 17
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443185
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 15
      Gene Ontology 5
      Phenotypes 38
    • Earliest
      J:63552 Yatsuki H, et al., Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. DNA Res. 2000 Jun 30;7(3):195-206
    • Latest
      J:262493 Lei W, et al., Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory