Trpm5
Gene Detail

Symbol Name ID

Trpm5 transient receptor potential cation channel, subfamily M, member 5 MGI:1861718

Synonyms

9430099A16Rik, Ltrpc5, Mtr1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr7:143069153-143094642 bp, - strand From VEGA annotation of GRCm38   25490 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Trpm5 ± 2 cM)

Protein SuperFamily: transient receptor potential cation channels TRPM4/TRPM5
Gene Tree: Trpm5

Human ortholog

TRPM5 transient receptor potential cation channel, subfamily M, member 5 NCBI Gene ID 29850
Human Synonyms: LTRPC5, MTR1
Human Chr11:2425745-2444275 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cation transport, ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	calcium activated cation channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (167)    Tissues (75)    Images (7)
Theiler Stages: 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	24
In situ reporter (knock in)	35
RT-PCR	108

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(16) Primer pair(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022683 (Evidence)
Ensembl Gene Model	ENSMUSG00000009246 (Evidence)
Entrez Gene	56843 (Evidence)
UniGene	286668
DFCI	TC1585762, TC1616422, TC1683575
DoTS	DT.101352813, DT.101722863, DT.87048507, DT.91387732, DT.91394818, DT.94236103
NIA Mouse Gene Index	U029493
Consensus CDS Project	CCDS52462.1
International Mouse Knockout Project Status	Trpm5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022683	VEGA Gene Model | MGI Sequence Detail	25490	C57BL/6J
transcript	OTTMUST00000054375	VEGA | MGI Sequence Detail	4123	Not Applicable
polypeptide	OTTMUSP00000025953	VEGA | MGI Sequence Detail	1158	Not Applicable

All sequences(57) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000016701	transient receptor potential cation channel subfamily M member 5

References

(Earliest) J:63552 Yatsuki H, et al., Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. DNA Res. 2000 Jun 30;7(3):195-206
(Latest) J:182009 Kyriazis GA, et al., Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E524-32
All references(63)

Other accession IDs

MGI:2443185