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Nme6 Gene Detail
Summary
  • Symbol
    Nme6
  • Name
    NME/NM23 nucleoside diphosphate kinase 6
  • Synonyms
    nm23-M6, non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861676
    NCBI Gene: 54369
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:109832749-109843116 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10368 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.79 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NME6, NME/NM23 nucleoside diphosphate kinase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NME6, NME/NM23 nucleoside diphosphate kinase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPIA-ALPHA, NDK 6, NM23-H6
  • Links
    NCBI Gene ID: 10201
    neXtProt AC: NX_O75414
    UniProt: O75414

  • Chr Location
    3p21.31; chr3:48289369-48302259 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030951 VEGA Gene Model | MGI Sequence Detail 10368 C57BL/6J ±  kb
    transcript OTTMUST00000076614 VEGA | MGI Sequence Detail 1074 Not Applicable  
    polypeptide OTTMUSP00000040367 VEGA | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      179 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 60

      Microarray probesets 3
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:62651 Mehus JG, et al., NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Hum Genet. 1999 Jun;104(6):454-9
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory