Nespas
Gene Detail

Symbol Name ID

Nespas neuroendocrine secretory protein antisense MGI:1861674

Synonyms

Gnas-as

Feature Type

unclassified non-coding RNA gene

Genetic Map

Chromosome 2

97.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:174281237-174295436 bp, - strand From VEGA annotation of GRCm38   14200 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Nespas

Alleles and phenotypes

All alleles(13) : Targeted(4) Gene trapped(9)
 

Mice heterozygous for a knock-out allele exhibit postnatal lethality, abnormal suckling, lethargy, decreased body size, and altered maternal imprinting.

 
Human Diseases Modeled Using Mouse Nespas (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process

DNA methylation, genetic imprinting, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (9)    Images (5)
Theiler Stages: 16, 17, 18, 19

Assay Type	Results
RNA in situ	10

cDNA source data(2)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(3) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000016620 (Evidence)
Ensembl Gene Model	ENSMUSG00000086537 (Evidence)
Entrez Gene	56802 (Evidence)
DFCI	TC1617523, TC1627256
DoTS	DT.60103822, DT.91328051, DT.97366468
NIA Mouse Gene Index	U063536
International Mouse Knockout Project Status	Nespas

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016620	VEGA Gene Model | MGI Sequence Detail	14200	C57BL/6J
transcript	OTTMUST00000040199	VEGA | MGI Sequence Detail	2248	Not Applicable

All sequences(22) RefSeq(1)

Polymorphisms

SNPs within 2kb(71 from dbSNP Build 137)

References

(Earliest) J:61327 Wroe SF, et al., An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3342-6
(Latest) J:183830 Fernandez-Rebollo E, et al., Loss of XLalphas (extra-large alphas) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6638-43
All references(24)