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Gnasas1 Gene Detail
Summary
  • Symbol
    Gnasas1
  • Name
    GNAS antisense RNA 1
  • Synonyms
    Gnas-as, Nespas
Location &
Maps
more
  • Sequence Map
    Chr2:174281237-174295436 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 97.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861674
antisense lncRNA gene Chr2:174281237-174295436 (-)
129S1/SvImJ MGP_129S1SvImJ_G0003713
antisense lncRNA gene Chr2:180627284-180641326 (-)
A/J MGP_AJ_G0003694
antisense lncRNA gene Chr2:173016163-173030220 (-)
AKR/J MGP_AKRJ_G0003672
antisense lncRNA gene Chr2:178231595-178245711 (-)
BALB/cJ MGP_BALBcJ_G0003683
antisense lncRNA gene Chr2:173406808-173420921 (-)
C3H/HeJ MGP_C3HHeJ_G0003630
antisense lncRNA gene Chr2:178608959-178623697 (-)
C57BL/6NJ MGP_C57BL6NJ_G0003822
antisense lncRNA gene Chr2:185824524-185842593 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0003328
antisense lncRNA gene Chr2:166257775-166272225 (-)
CAST/EiJ MGP_CASTEiJ_G0003593
antisense lncRNA gene Chr2:179336280-179350803 (-)
CBA/J MGP_CBAJ_G0003627
antisense lncRNA gene Chr2:192743640-192757770 (-)
DBA/2J MGP_DBA2J_G0003634
antisense lncRNA gene Chr2:172116374-172130181 (-)
FVB/NJ MGP_FVBNJ_G0003656
antisense lncRNA gene Chr2:170739323-170753354 (-)
LP/J MGP_LPJ_G0003713
antisense lncRNA gene Chr2:180537667-180551840 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0003644
antisense lncRNA gene Chr2:195641711-195656662 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0003823
antisense lncRNA gene Chr2:178254953-178269893 (-)
PWK/PhJ MGP_PWKPhJ_G0003548
antisense lncRNA gene Chr2:171923988-171938523 (-)
SPRET/EiJ MGP_SPRETEiJ_G0003491
antisense lncRNA gene Chr2:177297465-177311616 (-)
WSB/EiJ MGP_WSBEiJ_G0003628
antisense lncRNA gene Chr2:179218551-179234729 (-)



Homology
more
  • Human Ortholog
    GNAS-AS1, GNAS antisense RNA 1
  • Human Ortholog
    GNAS-AS1, GNAS antisense RNA 1
    Orthology source: HGNC
  • Synonyms
    GNAS1AS, GNASAS, GNAS-AS, NCRNA00075, NESPAS, NESP-AS, SANG
  • Links
    NCBI Gene ID: 149775

  • Chr Location
    20q13.32; chr20:58818918-58850903 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gnasas1 mouse models; 1 with human GNAS-AS1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit postnatal lethality, abnormal suckling, lethargy, decreased body size, and altered maternal imprinting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56802 NCBI Gene Model | MGI Sequence Detail 14200 C57BL/6J ±  kb
    transcript NR_002846 RefSeq | MGI Sequence Detail 2248 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 3
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:61327 Wroe SF, et al., An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3342-6
    • Latest
      J:254234 Kweon SM, et al., Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease. Cell Rep. 2017 Oct 10;21(2):482-494

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory