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Nespas Gene Detail
Summary
  • Symbol
    Nespas
  • Name
    neuroendocrine secretory protein antisense
  • Synonyms
    Gnas-as
  • Feature Type
    antisense lncRNA gene
  • IDs
    MGI:1861674
    NCBI Gene: 56802
Location & Maps
more
  • Sequence Map
    Chr2:174281237-174295436 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14200 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 97.89 cM
  • Mapping Data
    1 experiment
Homology
less
Human Diseases
more
  • Diseases
    1 with Nespas mouse models

Human Disease Mouse Models
       Pseudohypoparathyroidism, Type IB; PHP1B   OMIM: 603233 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    9
  • Targeted
    5
  • Genomic Mutations
    1 involving Nespas
Mice heterozygous for a knock-out allele exhibit postnatal lethality, abnormal suckling, lethargy, decreased body size, and altered maternal imprinting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016620 VEGA Gene Model | MGI Sequence Detail 14200 C57BL/6J ±  kb
transcript OTTMUST00000040199 VEGA | MGI Sequence Detail 2248 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    70 from dbSNP Build 142
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:61327 Wroe SF, et al., An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3342-6
  • Latest
    J:203466 Ball ST, et al., Gene Dosage Effects at the Imprinted Cluster. PLoS One. 2013;8(6):e65639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory