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Gbf1
Gene Detail
 Symbol
Name
ID
Gbf1
golgi-specific brefeldin A-resistance factor 1
MGI:1861607
Synonyms 1700083E03Rik, mKIAA0248
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:46152509-46286510 bp, + strand
From VEGA annotation of GRCm38

  134002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: brefeldin A-inhibited guanine nucleotide-exchange protein
Gene Tree: Gbf1

Human
homologs
Human Homolog GBF1, golgi brefeldin A resistant guanine nucleotide exchange factor 1
NCBI Gene ID 8729
neXtProt AC  NX_Q92538
Human Synonyms  ARF1GEF
Human Chr (Location)  10q24; chr10:102245498-102382899 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gbf1 interacts with 193 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process positive regulation of GTPase activity, vesicle-mediated transport
Component cis-Golgi network, endoplasmic reticulum lumen, ...
Function ARF guanyl-nucleotide exchange factor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (4)   
Theiler Stages: 19, 21, 23, 27
Assay TypeResults
RT-PCR 11
cDNA source data(222)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(223) cDNA(222) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000040139 (Evidence)
Ensembl Gene ModelENSMUSG00000025224 (Evidence)
Entrez Gene107338 (Evidence)
UniGene271620
DFCITC1572777, TC1596592, TC1597500, TC1680665, TC1716483
DoTSDT.101157879, DT.101187828, DT.101399355, DT.102557690, DT.55180816, DT.87055542, DT.97369001
NIA Mouse Gene IndexU019520, U039104
Consensus CDS ProjectCCDS29873.1
International Mouse Knockout Project StatusGbf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040139 VEGA Gene Model | MGI Sequence Detail 134002 C57BL/6J ±  kb
transcript OTTMUST00000104289 VEGA | MGI Sequence Detail 6450 Not Applicable 
polypeptide OTTMUSP00000058353 VEGA | MGI Sequence Detail 1861 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(10) UniProt(11)
Polymorphisms SNPs within 2kb(508 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000904 SEC7-like
InterPro IPR023394 SEC7-like, alpha orthogonal bundle
Protein Ontology PR:000007872 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
References (Earliest) J:63167 Semina EV, et al., Deletion in the promoter region and altered expression of pitx3 homeobox gene in aphakia mice. Hum Mol Genet. 2000 Jul 1;9(11):1575-85
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:1920768, MGI:2147472, MGI:2147694

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory