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Tacstd2
Gene Detail
 Symbol
Name
ID
Tacstd2
tumor-associated calcium signal transducer 2
MGI:1861606
Synonyms EGP-1, GA733-1, Ly97, TROP2
Feature Type protein coding gene
Genetic Map
Chromosome 6
30.88 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:67534059-67535822 bp, - strand
From NCBI annotation of GRCm38

  1764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: epithelial glycoprotein antigen GA733
Gene Tree: Tacstd2

Human
homologs
Human Homolog TACSTD2, tumor-associated calcium signal transducer 2
NCBI Gene ID 4070
neXtProt AC  NX_P09758
Human Synonyms  EGP1, EGP-1, GA7331, GA733-1, GP50, M1S1, TROP2
Human Chr (Location)  1p32; chr1:58575423-58577494 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TACSTD2
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal development, life expectancy and tumorigenesis. When combined with a Cdkn2a knock-out allele, mice exhibit increased incidence of induced spindle cell carcinoma and immortalized keratinocyte proliferation and migration.
 
Interactions
Tacstd2 interacts with 125 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process negative regulation of branching involved in ureteric bud morphogenesis, negative regulation of cell motility, ...
Component basal plasma membrane, extracellular space, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (62)    Tissues (16)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 62
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000051397 (Evidence)
Entrez Gene56753 (Evidence)
UniGene439913
DFCITC1578728
DoTSDT.490791, DT.55273953
NIA Mouse Gene IndexU027414
Consensus CDS ProjectCCDS20221.1
International Mouse Knockout Project StatusTacstd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56753 NCBI Gene Model | MGI Sequence Detail 1764 C57BL/6J ±  kb
transcript NM_020047 RefSeq | MGI Sequence Detail 1764 Not Specified 
polypeptide Q8BGV3 UniProt | EBI | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000016009 tumor-associated calcium signal transducer 2
Graphical View of Protein Domain Structure
References (Earliest) J:45493 El Sewedy T, et al., Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. Int J Cancer. 1998 Jan 19;75(2):324-30
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(35)
Other
accession IDs
MGI:1341400, MGI:2141761

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory