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Tacstd2
Gene Detail
Symbol

Name
ID
Tacstd2
tumor-associated calcium signal transducer 2
MGI:1861606
Synonyms
EGP-1, GA733-1, Ly97, TROP2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
30.88 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:67534062-67535796 bp, - strand
From VEGA annotation of GRCm38

  1735 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TACSTD2
Protein SuperFamily: epithelial glycoprotein antigen GA733
Gene Tree: Tacstd2

Human
homologs
TACSTD2, tumor-associated calcium signal transducer 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4070
neXtProt AC: NX_P09758

Human Synonyms: EGP1, EGP-1, GA7331, GA733-1, GP50, M1S1, TROP2

Human Chr (Location): 1p32; chr1:58575423-58577494 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TACSTD2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal development, life expectancy and tumorigenesis. When combined with a Cdkn2a knock-out allele, mice exhibit increased incidence of induced spindle cell carcinoma and immortalized keratinocyte proliferation and migration.
 
Interactions
Tacstd2 interacts with 125 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (16)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000052511 (Evidence)
Ensembl Gene Model ENSMUSG00000051397 (Evidence)
Entrez Gene 56753 (Evidence)
UniGene 439913
DFCI TC1578728
DoTS DT.490791, DT.55273953
NIA Mouse Gene Index U027414
Consensus CDS Project CCDS20221.1
International Mouse Phenotyping Consortium Status Tacstd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052511 VEGA Gene Model | MGI Sequence Detail 1735 C57BL/6J ±  kb
transcript OTTMUST00000131690 VEGA | MGI Sequence Detail 1735 Not Applicable 
polypeptide OTTMUSP00000070365 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000016009 tumor-associated calcium signal transducer 2
References
(Earliest) J:45493 El Sewedy T, et al., Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. Int J Cancer. 1998 Jan 19;75(2):324-30
(Latest) J:215310 Sun W, et al., Identification of potential bladder progenitor cells in the trigone. Dev Biol. 2014 Sep 1;393(1):84-92
All references(37)
Other
accession IDs
MGI:1341400, MGI:2141761

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory