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Tacstd2 Gene Detail
Summary
  • Symbol
    Tacstd2
  • Name
    tumor-associated calcium signal transducer 2
  • Synonyms
    EGP-1, GA733-1, Ly97, TROP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861606
    NCBI Gene: 56753
  • Gene Overview
    MyGene.info: TACSTD2
Location & Maps
more
  • Sequence Map
    Chr6:67534062-67535796 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1735 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.88 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TACSTD2, tumor-associated calcium signal transducer 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TACSTD2, tumor-associated calcium signal transducer 2
    Orthology source: HomoloGene
  • Synonyms
    EGP1, EGP-1, GA7331, GA733-1, GP50, M1S1, TROP2
  • Links
    NCBI Gene ID: 4070
    neXtProt AC: NX_P09758

  • Chr Location
    1p32; chr1:58575423-58577494 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TACSTD2 associations

Human Disease Mouse Models
       Corneal Dystrophy, Gelatinous Drop-Like; GDLD   OMIM: 204870
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    1 phenotype reference
Mice homozygous for a knock-out allele exhibit normal development, life expectancy and tumorigenesis. When combined with a Cdkn2a knock-out allele, mice exhibit increased incidence of induced spindle cell carcinoma and immortalized keratinocyte proliferation and migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052511 VEGA Gene Model | MGI Sequence Detail 1735 C57BL/6J ±  kb
transcript OTTMUST00000131690 VEGA | MGI Sequence Detail 1735 Not Applicable  
polypeptide OTTMUSP00000070365 VEGA | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016009 tumor-associated calcium signal transducer 2
  • InterPro Domains
    IPR000716 Thyroglobulin type-1
Molecular
Reagents
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  • All nucleic 41
    cDNA 41

    Microarray probesets 4
Other
Accession IDs
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MGI:1341400, MGI:2141761
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:45493 El Sewedy T, et al., Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. Int J Cancer. 1998 Jan 19;75(2):324-30
  • Latest
    J:215310 Sun W, et al., Identification of potential bladder progenitor cells in the trigone. Dev Biol. 2014 Sep 1;393(1):84-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory