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Cpsf2 Gene Detail
Summary
  • Symbol
    Cpsf2
  • Name
    cleavage and polyadenylation specific factor 2
  • Synonyms
    100kDa, 2610024B04Rik, Cpsf, mKIAA1367
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861601
    NCBI Gene: 51786
  • Gene Overview
    MyGene.info: CPSF2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:101975764-102005993 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 51.34 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861601
protein coding gene Chr12:101975764-102006424 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020028
protein coding gene Chr12:103582536-103616647 (+)
A/J MGP_AJ_G0019984
protein coding gene Chr12:99606269-99636189 (+)
AKR/J MGP_AKRJ_G0019960
protein coding gene Chr12:102446343-102479201 (+)
BALB/cJ MGP_BALBcJ_G0019970
protein coding gene Chr12:99948690-99980529 (+)
C3H/HeJ MGP_C3HHeJ_G0019772
protein coding gene Chr12:102894256-102926787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020419
protein coding gene Chr12:106827324-106857954 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018032
protein coding gene Chr12:96632195-96662517 (+)
CAST/EiJ MGP_CASTEiJ_G0019318
protein coding gene Chr12:97716463-97776929 (+)
CBA/J MGP_CBAJ_G0019744
protein coding gene Chr12:110766832-110798523 (+)
DBA/2J MGP_DBA2J_G0019855
protein coding gene Chr12:99132226-99162266 (+)
FVB/NJ MGP_FVBNJ_G0019844
protein coding gene Chr12:97851258-97881993 (+)
LP/J MGP_LPJ_G0019931
protein coding gene Chr12:103438329-103471250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019884
protein coding gene Chr12:114263839-114296094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020448
protein coding gene Chr12:101944509-101974893 (+)
PWK/PhJ MGP_PWKPhJ_G0019081
protein coding gene Chr12:93684732-93716816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018877
protein coding gene Chr12:96121938-96154674 (+)
WSB/EiJ MGP_WSBEiJ_G0019372
protein coding gene Chr12:102827411-102858245 (+)



Homology
more
  • Human Ortholog
    CPSF2, cleavage and polyadenylation specific factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPSF2, cleavage and polyadenylation specific factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPSF100
  • Links
    NCBI Gene ID: 53981
    neXtProt AC: NX_Q9P2I0
    UniProt: Q9P2I0

  • Chr Location
    14q32.12; chr14:92121954-92164199 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 51786 NCBI Gene Model | MGI Sequence Detail 30230 C57BL/6J ±  kb
transcript NM_016856 RefSeq | MGI Sequence Detail 5315 C57BL/6  
polypeptide O35218 UniProt | EBI | MGI Sequence Detail 782 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005829 cleavage and polyadenylation specificity factor subunit 2
  • InterPro Domains
    IPR022712 Beta-Casp domain
    IPR025069 Cleavage and polyadenylation specificity factor 2, C-terminal
    IPR027075 Cleavage and polyadenylation specificity factor subunit 2
    IPR035639 CPSF2, metallo-hydrolase domain
    IPR001279 Metallo-beta-lactamase
    IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
    IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917185, MGI:2144878
References
more
  • Summaries
    All 41
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory