Cpsf2 MGI Mouse Gene Detail - MGI:1861601 - cleavage and polyadenylation specific factor 2

Symbol

Cpsf2
Name

cleavage and polyadenylation specific factor 2
Synonyms

100kDa, 2610024B04Rik, Cpsf, mKIAA1367

Feature Type

protein coding gene
IDs

MGI:1861601
NCBI Gene: 51786
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:101942247-101972683 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 51.34 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

1017 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861601	protein coding gene	Chr12:101940345-101972683 (+)
129S1/SvImJ	ENSMUSG00200022919	protein coding gene	Chr12:93745971-93776422 (+)
A/J	ENSMUSG00195018938	protein coding gene	Chr12:96272658-96303098 (+)
AKR/J	ENSMUSG00220034296	protein coding gene	Chr12:94219745-94249892 (+)
BALB/cJ	ENSMUSG00180030746	protein coding gene	Chr12:95465809-95495957 (+)
C3H/HeJ	ENSMUSG00175033561	protein coding gene	Chr12:98085615-98116050 (+)
C57BL/6NJ	ENSMUSG00215039682	protein coding gene	Chr12:94743760-94774198 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018032	protein coding gene	Chr12:96632195-96662517 (+)
CAST/EiJ	ENSTCUG00005017577	protein coding gene	Chr12:94129798-94162410 (+)
CBA/J	ENSMUSG00210014528	protein coding gene	Chr12:95120118-95150267 (+)
DBA/2J	ENSMUSG00185042184	protein coding gene	Chr12:96920671-96950931 (+)
FVB/NJ	ENSMUSG00205015435	protein coding gene	Chr12:94137556-94168006 (+)
JF1/MsJ	ENSUMUG00000008093	protein coding gene	Chr12:101660598-101693091 (+)
LP/J	ENSMUSG00230024962	protein coding gene	Chr12:104011000-104041450 (+)
NOD/ShiLtJ	ENSMUSG00190025519	protein coding gene	Chr12:90988444-91018590 (-)
NZO/HlLtJ	ENSMUSG00225037281	protein coding gene	Chr12:105730011-105760158 (+)
PWK/PhJ	ENSLUMG00010012959	protein coding gene	Chr12:95108111-95140608 (+)
SPRET/EiJ	ENSMSPG00010016471	protein coding gene	Chr12:97615722-97646400 (+)
WSB/EiJ	ENSIUOG00005008672	protein coding gene	Chr12:94143565-94173955 (+)

Human Ortholog

CPSF2, cleavage and polyadenylation specific factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CPSF2, cleavage and polyadenylation specific factor 2
Synonyms

CPSF100
Links

HGNC:2325

NCBI Gene ID: 53981

UniProt: Q9P2I0
Chr Location

14q32.12; chr14:92121512-92172145 (+) GRCh38

MGI Vertebrate Homology

Cpsf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CPSF2
Gene Tree

Cpsf2

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

27
Targeted

2
Genomic Mutations

1 involving Cpsf2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

598
Tissues

1
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpsf2

ZFIN cpsf2

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All Sequences

53
RefSeq

4
UniProt

5
CCDS

CCDS26116.1

Ensembl

ENSMUSG00000041781 (Evidence)
NCBI Gene

51786

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041781	Ensembl Gene Model \| MGI Sequence Detail	30437	C57BL/6J	± kb
transcript	ENSMUST00000047357	Ensembl \| MGI Sequence Detail	5732	Not Applicable
polypeptide	ENSMUSP00000047797	Ensembl \| MGI Sequence Detail	782	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005829 cleavage and polyadenylation specificity factor subunit 2

(term hierarchy)
InterPro Domains

IPR022712 Beta-Casp domain

IPR025069 Cleavage and polyadenylation specificity factor 2, C-terminal

IPR027075 Cleavage and polyadenylation specificity factor subunit 2

IPR035639 CPSF2, metallo-hydrolase domain

IPR001279 Metallo-beta-lactamase

IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain
GlyGen

O35218 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 15

Antibodies 1

Microarray probesets 6

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MGI:1917185, MGI:2144878

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326556 Wang Y, et al., DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Nat Commun. 2022 Jul 1;13(1):3794

TSS for Cpsf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114729	Chr12:101941625-101941630 (+)	-619 bp
Tssr114730	Chr12:101941984-101942010 (+)	-250 bp
Tssr114731	Chr12:101942224-101942263 (+)	-3 bp
Tssr114732	Chr12:101942265-101942276 (+)	24 bp
Tssr114733	Chr12:101971793-101971841 (+)	29,570 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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