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Tulp2 Gene Detail
Summary
  • Symbol
    Tulp2
  • Name
    tubby-like protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861600
    NCBI Gene: 56734
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45131450-45173070 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861600
protein coding gene Chr7:45131301-45173070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032226
protein coding gene Chr7:45757722-45800344 (+)
A/J MGP_AJ_G0032205
protein coding gene Chr7:44875300-44912626 (+)
AKR/J MGP_AKRJ_G0032141
protein coding gene Chr7:46121058-46158502 (+)
BALB/cJ MGP_BALBcJ_G0032217
protein coding gene Chr7:44864380-44902998 (+)
C3H/HeJ MGP_C3HHeJ_G0031932
protein coding gene Chr7:46606762-46647603 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032709
protein coding gene Chr7:48028867-48068554 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029723
protein coding gene Chr7:47420291-47458687 (+)
CAST/EiJ MGP_CASTEiJ_G0031261
protein coding gene Chr7:38029632-38068731 (+)
CBA/J MGP_CBAJ_G0031897
protein coding gene Chr7:49615887-49653701 (+)
DBA/2J MGP_DBA2J_G0032055
protein coding gene Chr7:44538966-44576720 (+)
FVB/NJ MGP_FVBNJ_G0032006
protein coding gene Chr7:44332109-44369368 (+)
LP/J MGP_LPJ_G0032133
protein coding gene Chr7:46451688-46498847 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032043
protein coding gene Chr7:48315615-48354599 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032725
protein coding gene Chr7:45333244-45372179 (+)
PWK/PhJ MGP_PWKPhJ_G0030983
protein coding gene Chr7:37918407-37956129 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030821
protein coding gene Chr7:33337695-33380935 (+)
WSB/EiJ MGP_WSBEiJ_G0031378
protein coding gene Chr7:45830330-45868914 (+)



Homology
more
  • Human Ortholog
    TULP2, TUB like protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TULP2, TUB like protein 2
  • Synonyms
    CT65, TUBL2
  • Links
    NCBI Gene ID: 7288
    neXtProt AC: NX_O00295
    UniProt: O00295

  • Chr Location
    19q13.33; chr19:48880817-48900177 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout leads to male infertility owing to impaired sperm motility caused by flagellum dysmorphologies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56734 NCBI Gene Model | MGI Sequence Detail 41621 C57BL/6J ±  kb
    transcript NM_001045555 RefSeq | MGI Sequence Detail 2216 C57BL/6  
    polypeptide P46686 UniProt | EBI | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16476, MGI:99691
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:17102 Vambutas V, et al., Identification and characterization of the developmentally regulated pattern of expression in the testis of a mouse gene exhibiting similarity to the family of phosphodiesterases. Biochim Biophys Acta. 1994 Mar 1;1217(2):203-6
    • Latest
      J:307539 Zheng M, et al., TULP2, a New RNA-Binding Protein, Is Required for Mouse Spermatid Differentiation and Male Fertility. Front Cell Dev Biol. 2021;9:623738

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/21/2021
    MGI 6.17
    The Jackson Laboratory