Tulp2 MGI Mouse Gene Detail - MGI:1861600

Symbol

Tulp2
Name

TUB like protein 2

Feature Type

protein coding gene
IDs

MGI:1861600
NCBI Gene: 56734
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:45131450-45173070 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.33 cM
Mapping Data

1 experiment

SNPs within 2kb

217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861600	protein coding gene	Chr7:45131301-45173070 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032226	protein coding gene	Chr7:45757722-45800344 (+)
A/J	MGP_AJ_G0032205	protein coding gene	Chr7:44875300-44912626 (+)
AKR/J	MGP_AKRJ_G0032141	protein coding gene	Chr7:46121058-46158502 (+)
BALB/cJ	MGP_BALBcJ_G0032217	protein coding gene	Chr7:44864380-44902998 (+)
C3H/HeJ	MGP_C3HHeJ_G0031932	protein coding gene	Chr7:46606762-46647603 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032709	protein coding gene	Chr7:48028867-48068554 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029723	protein coding gene	Chr7:47420291-47458687 (+)
CAST/EiJ	MGP_CASTEiJ_G0031261	protein coding gene	Chr7:38029632-38068731 (+)
CBA/J	MGP_CBAJ_G0031897	protein coding gene	Chr7:49615887-49653701 (+)
DBA/2J	MGP_DBA2J_G0032055	protein coding gene	Chr7:44538966-44576720 (+)
FVB/NJ	MGP_FVBNJ_G0032006	protein coding gene	Chr7:44332109-44369368 (+)
LP/J	MGP_LPJ_G0032133	protein coding gene	Chr7:46451688-46498847 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032043	protein coding gene	Chr7:48315615-48354599 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032725	protein coding gene	Chr7:45333244-45372179 (+)
PWK/PhJ	MGP_PWKPhJ_G0030983	protein coding gene	Chr7:37918407-37956129 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030821	protein coding gene	Chr7:33337695-33380935 (+)
WSB/EiJ	MGP_WSBEiJ_G0031378	protein coding gene	Chr7:45830330-45868914 (+)

Human Ortholog

TULP2, TUB like protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TULP2, TUB like protein 2
Synonyms

CT65, TUBL2
Links

HGNC:12424

NCBI Gene ID: 7288

neXtProt AC: NX_O00295

UniProt: O00295
Chr Location

19q13.33; chr19:48880965-48898744 (-) GRCh38

MGI Vertebrate Homology

Tulp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TULP2
Gene Tree

Tulp2

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Endonuclease-mediated

3
Gene trapped

30
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout leads to male infertility owing to impaired sperm motility caused by flagellum dysmorphologies.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

40
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tulp2

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All Sequences

94
RefSeq

36
UniProt

5
CCDS

CCDS39953.1, CCDS39954.1, CCDS71960.1, CCDS71961.1, CCDS80720.1

Ensembl

ENSMUSG00000023467 (Evidence)
NCBI Gene

56734

			Length	Strain/Species	Flank
genomic	56734	NCBI Gene Model \| MGI Sequence Detail	41621	C57BL/6J	± kb
transcript	NM_001045555	RefSeq \| MGI Sequence Detail	2216	C57BL/6
polypeptide	P46686	UniProt \| EBI \| MGI Sequence Detail	562	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016835 tubby-related protein 2

(term hierarchy)
InterPro Domains

IPR000007 Tubby, C-terminal

IPR018066 Tubby, C-terminal, conserved site

IPR025659 Tubby-like, C-terminal

IPR005398 Tubby, N-terminal

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All nucleic 41

cDNA 40

Primer pair 1

Microarray probesets 3

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MGD-MRK-16476, MGI:99691

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 10
Earliest

J:17102 Vambutas V, et al., Identification and characterization of the developmentally regulated pattern of expression in the testis of a mouse gene exhibiting similarity to the family of phosphodiesterases. Biochim Biophys Acta. 1994 Mar 1;1217(2):203-6
Latest

J:336151 Oyama Y, et al., TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility. Reprod Med Biol. 2022;21(1):e12467

TSS for Tulp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66543	Chr7:45131176-45131190 (+)	-267 bp
Tssr66544	Chr7:45135683-45135698 (+)	4,241 bp
Tssr66545	Chr7:45135703-45135740 (+)	4,272 bp
Tssr66546	Chr7:45135762-45135763 (+)	4,313 bp
Tssr66547	Chr7:45135784-45135823 (+)	4,354 bp
Tssr66548	Chr7:45163125-45163134 (+)	31,680 bp
Tssr66549	Chr7:45163142-45163171 (+)	31,707 bp
Tssr66550	Chr7:45164020-45164038 (+)	32,579 bp
Tssr66551	Chr7:45164043-45164066 (+)	32,605 bp
Tssr66552	Chr7:45167663-45167687 (+)	36,225 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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