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Krt71 Gene Detail
Summary
  • Symbol
    Krt71
  • Name
    keratin 71
  • Synonyms
    Ca, Cal4, Cu, Krt2-6g, mK6irs, mK6irs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861586
    NCBI Gene: 56735
Location & Maps
more
  • Sequence Map
    Chr15:101733950-101743109 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9160 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KRT71, keratin 71
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KRT71, keratin 71
    Orthology source: HomoloGene
  • Synonyms
    HYPT13, K6IRS1, KRT6IRS, KRT6IRS1
  • Links
    NCBI Gene ID: 112802
    neXtProt AC: NX_Q3SY84

  • Chr Location
    12q13.13; chr12:52543909-52553147 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Krt71 mouse models; 1 with human KRT71 associations

Human Disease Mouse Models
       Hypotrichosis 13; HYPT13   OMIM: 615896 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 18 alleles in 18 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (ENU)
    5
  • Chemically induced (other)
    1
  • Radiation induced
    3
  • Spontaneous
    17
  • Targeted
    5
  • Genomic Mutations
    4 involving Krt71
  • Incidental Mutations
Mutations in this gene result in waved hair and curly vibrissae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027989 VEGA Gene Model | MGI Sequence Detail 9160 C57BL/6J ±  kb
transcript OTTMUST00000069333 VEGA | MGI Sequence Detail 2185 Not Applicable  
polypeptide OTTMUSP00000035196 VEGA | MGI Sequence Detail 524 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009486 keratin, type II cytoskeletal 71
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 137
    Genomic 1
    cDNA 136

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1716, MGD-MRK-2251, MGI:2145920, MGI:3044778, MGI:88238
References
more
  • Summaries
    All 88
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 6
    Phenotypes 47
  • Earliest
    J:13054 Dunn LC, Caracul, a dominant mutation. J Hered. 1937;28:334
  • Latest
    J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory