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Pigo Gene Detail
Summary
  • Symbol
    Pigo
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class O
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861452
    NCBI Gene: 56703
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43017635-43025819 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 22.98 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861452
protein coding gene Chr4:43017626-43026374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028198
protein coding gene Chr4:41098525-41108048 (-)
A/J MGP_AJ_G0028154
protein coding gene Chr4:39658723-39666895 (-)
AKR/J MGP_AKRJ_G0028106
protein coding gene Chr4:40563766-40571960 (-)
BALB/cJ MGP_BALBcJ_G0028174
protein coding gene Chr4:39750347-39758535 (-)
C3H/HeJ MGP_C3HHeJ_G0027896
protein coding gene Chr4:41186640-41194821 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028615
protein coding gene Chr4:42633405-42641601 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025927
protein coding gene Chr4:37121943-37130578 (-)
CAST/EiJ MGP_CASTEiJ_G0027336
protein coding gene Chr4:40657554-40668316 (-)
CBA/J MGP_CBAJ_G0027862
protein coding gene Chr4:43974397-43982573 (-)
DBA/2J MGP_DBA2J_G0028011
protein coding gene Chr4:39573754-39581928 (-)
FVB/NJ MGP_FVBNJ_G0027978
protein coding gene Chr4:38794900-38803076 (-)
LP/J MGP_LPJ_G0028110
protein coding gene Chr4:41167147-41175333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028002
protein coding gene Chr4:47240962-47249156 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028651
protein coding gene Chr4:40757196-40765370 (-)
PWK/PhJ MGP_PWKPhJ_G0027062
protein coding gene Chr4:39606260-39614465 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026888
protein coding gene Chr4:40308826-40317798 (-)
WSB/EiJ MGP_WSBEiJ_G0027416
protein coding gene Chr4:40663288-40671462 (-)



Homology
more
  • Human Ortholog
    PIGO, phosphatidylinositol glycan anchor biosynthesis class O
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGO, phosphatidylinositol glycan anchor biosynthesis class O
  • Synonyms
    HPMRS2
  • Links
    NCBI Gene ID: 84720
    neXtProt AC: NX_Q8TEQ8
    UniProt: Q8TEQ8

  • Chr Location
    9p13.3; chr9:35087237-35096619 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human PIGO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028454 Ensembl Gene Model | MGI Sequence Detail 8185 C57BL/6J ±  kb
    transcript ENSMUST00000098109 Ensembl | MGI Sequence Detail 4239 Not Applicable  
    polypeptide ENSMUSP00000095713 Ensembl | MGI Sequence Detail 1101 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012702 GPI ethanolamine phosphate transferase 3
    • EC
    • InterPro Domains
      IPR017850 Alkaline-phosphatase-like, core domain superfamily
      IPR039524 GPI ethanolamine phosphate transferase 3
      IPR037675 GPI ethanolamine phosphate transferase 3, N-terminal
      IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 74

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:63222 Hong Y, et al., Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J Biol Chem. 2000 Jul 7;275(27):20911-9
    • Latest
      J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory