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Pigo
Gene Detail
Symbol

Name
ID
Pigo
phosphatidylinositol glycan anchor biosynthesis, class O
MGI:1861452
Feature Type
protein coding gene
Genetic Map
Chromosome 4
22.98 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:43017635-43025819 bp, - strand
From VEGA annotation of GRCm38

  8185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31761  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIGO
Gene Tree: Pigo

Human
homologs
PIGO, phosphatidylinositol glycan anchor biosynthesis, class O
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84720
neXtProt AC: NX_Q8TEQ8

Human Synonyms: HPMRS2

Human Chr (Location): 9p13.3; chr9:35088688-35096601 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PIGO

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pigo interacts with 49 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process GPI anchor biosynthetic process, metabolic process
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function catalytic activity, Kdo transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (129)    Tissues (103)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 129
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pigo    NEW 
Molecular
reagents
All nucleic(73) cDNA(73)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006691 (Evidence)
Ensembl Gene Model ENSMUSG00000028454 (Evidence)
Entrez Gene 56703 (Evidence)
UniGene 143738
DFCI TC1625073, TC1575546, TC1632887
DoTS DT.94273436, DT.40157521, DT.101391570, DT.487282
NIA Mouse Gene Index U024982
EC 2.-.-.-
Consensus CDS Project CCDS18088.1
International Mouse Phenotyping Consortium Status Pigo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006691 VEGA Gene Model | MGI Sequence Detail 8185 C57BL/6J ±  kb
transcript OTTMUST00000015350 VEGA | MGI Sequence Detail 4239 Not Applicable 
polypeptide OTTMUSP00000007085 VEGA | MGI Sequence Detail 1101 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(11) UniProt(7)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology PR:000012702 GPI ethanolamine phosphate transferase 3
References
(Earliest) J:63222 Hong Y, et al., Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. J Biol Chem. 2000 Jul 7;275(27):20911-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory