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Ankrd2 Gene Detail
Summary
  • Symbol
    Ankrd2
  • Name
    ankyrin repeat domain 2 (stretch responsive muscle)
  • Synonyms
    Arpp, mArpp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861447
    NCBI Gene: 56642
  • Gene Overview
    MyGene.info: ANKRD2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42036038-42045110 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.65 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861447
protein coding gene Chr19:42035918-42045111 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025135
protein coding gene Chr19:41347823-41357774 (+)
A/J MGP_AJ_G0025112
protein coding gene Chr19:39361178-39370292 (+)
AKR/J MGP_AKRJ_G0025080
protein coding gene Chr19:40652534-40661638 (+)
BALB/cJ MGP_BALBcJ_G0025106
protein coding gene Chr19:39421580-39430696 (+)
C3H/HeJ MGP_C3HHeJ_G0024866
protein coding gene Chr19:40801429-40810536 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025549
protein coding gene Chr19:42413611-42422675 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022963
protein coding gene Chr19:38712751-38721968 (+)
CAST/EiJ MGP_CASTEiJ_G0024331
protein coding gene Chr19:40478067-40487327 (+)
CBA/J MGP_CBAJ_G0024846
protein coding gene Chr19:44497937-44509667 (+)
DBA/2J MGP_DBA2J_G0024978
protein coding gene Chr19:39211240-39220354 (+)
FVB/NJ MGP_FVBNJ_G0024939
protein coding gene Chr19:38985796-38994895 (+)
LP/J MGP_LPJ_G0025064
protein coding gene Chr19:41339437-41348547 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024970
protein coding gene Chr19:44117513-44126631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025607
protein coding gene Chr19:40691307-40700428 (+)
PWK/PhJ MGP_PWKPhJ_G0024080
protein coding gene Chr19:39087637-39097472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023884
protein coding gene Chr19:39436974-39445979 (+)
WSB/EiJ MGP_WSBEiJ_G0024401
protein coding gene Chr19:40843357-40853000 (+)



Homology
more
  • Human Ortholog
    ANKRD2, ankyrin repeat domain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANKRD2, ankyrin repeat domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARPP
  • Links
    NCBI Gene ID: 26287
    neXtProt AC: NX_Q9GZV1
    UniProt: Q9GZV1

  • Chr Location
    10q24.2; chr10:97572441-97583884 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10568
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANKRD2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile and free of cardiac defects but exhibit altered inflammatory responses and are prone to skeletal muscle fiber-type switching of slow fibers toward a faster phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025172 Ensembl Gene Model | MGI Sequence Detail 9073 C57BL/6J ±  kb
    transcript ENSMUST00000026172 Ensembl | MGI Sequence Detail 1100 Not Applicable  
    polypeptide ENSMUSP00000026172 Ensembl | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 6
    • Earliest
      J:63227 Kemp TJ, et al., Identification of ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. Genomics. 2000 Jun 15;66(3):229-41
    • Latest
      J:239677 Andrade EC, et al., ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). J Neurosci. 2017 Mar 08;37(10):2709-2722

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory