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Ankrd2 Gene Detail
Summary
  • Symbol
    Ankrd2
  • Name
    ankyrin repeat domain 2 (stretch responsive muscle)
  • Synonyms
    Arpp, mArpp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861447
    NCBI Gene: 56642
  • Gene Overview
    MyGene.info: ANKRD2
Location & Maps
more
  • Sequence Map
    Chr19:42036038-42045110 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9073 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 35.65 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANKRD2, ankyrin repeat domain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANKRD2, ankyrin repeat domain 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARPP
  • Links
    NCBI Gene ID: 26287
    neXtProt AC: NX_Q9GZV1

  • Chr Location
    10q23; chr10:97572441-97583884 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile and free of cardiac defects but exhibit altered inflammatory responses and are prone to skeletal muscle fiber-type switching of slow fibers toward a faster phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025172 Ensembl Gene Model | MGI Sequence Detail 9073 C57BL/6J ±  kb
transcript ENSMUST00000026172 Ensembl | MGI Sequence Detail 1100 Not Applicable  
polypeptide ENSMUSP00000026172 Ensembl | MGI Sequence Detail 328 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004044 ankyrin repeat domain-containing protein 2
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 5
  • Earliest
    J:63227 Kemp TJ, et al., Identification of ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. Genomics. 2000 Jun 15;66(3):229-41
  • Latest
    J:215212 Bang ML, et al., The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload. PLoS One. 2014;9(4):e93638

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory