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Ctsf
Gene Detail
Symbol

Name
ID
Ctsf
cathepsin F
MGI:1861434
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:4855129-4860912 bp, + strand
From NCBI annotation of GRCm38

  5784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31194  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTSF
Gene Tree: Ctsf

Human
homologs
CTSF, cathepsin F
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8722
neXtProt AC: NX_Q9UBX1

Human Synonyms: CATSF, CLN13

Human Chr (Location): 11q13; chr11:66563463-66568576 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CTSF

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele develop neuronal lipofuscinosis and late-onset neurological disease characterized by reduced brain mass, progressive hind leg weakness, impaired motor coordination, tremors, severe gliosis, general wasting, and premature death.
 
Interactions
Ctsf interacts with 57 markers (Mir19a, Mir22, Mir29a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (7)    Tissues (2)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctsf ; ZFIN ctsf    NEW 
Molecular
reagents
All nucleic(64) cDNA(64)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000083282 (Evidence)
Entrez Gene 56464 (Evidence)
UniGene 29561
DFCI TC1576876, TC1647567
DoTS DT.532601, DT.101187327, DT.94204610, DT.97368011
EC 3.4.22.41
Consensus CDS Project CCDS29440.1
International Mouse Phenotyping Consortium Status Ctsf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56464 NCBI Gene Model | MGI Sequence Detail 5784 C57BL/6J ±  kb
transcript NM_019861 RefSeq | MGI Sequence Detail 1975 129P2/Ola 
polypeptide Q9R013 UniProt | EBI | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
InterPro IPR013201 Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology PR:000006027 cathepsin F
Graphical View of Protein Domain Structure
References
(Earliest) J:63119 Deussing J, et al., Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. Gene. 2000 Jun 27;251(2):165-73
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2147567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory