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Klk4 Gene Detail
Summary
  • Symbol
    Klk4
  • Name
    kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
  • Synonyms
    ESMP1, KLK-L1, Prss17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861379
    NCBI Gene: 56640
  • Gene Overview
    MyGene.info: KLK4
Location & Maps
more
  • Sequence Map
    Chr7:43881160-43885804 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4645 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.35 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KLK4, kallikrein related peptidase 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KLK4, kallikrein related peptidase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AI2A1, ARM1, EMSP, EMSP1, kallikrein, KLK-L1, PRSS17, PSTS
  • Links
    NCBI Gene ID: 9622
    neXtProt AC: NX_Q9Y5K2

  • Chr Location
    19q13.41; chr19:50906352-50910749 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KLK4 associations

Human Disease Mouse Models
       Amelogenesis Imperfecta, Hypomaturation Type, Iia1; AI2A1   OMIM: 204700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced enamel strength that leads to enamel fracturing, delayed postnatal growth, and decreased survival to maturity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058315 VEGA Gene Model | MGI Sequence Detail 4645 C57BL/6J ±  kb
transcript OTTMUST00000143202 VEGA | MGI Sequence Detail 1249 Not Applicable  
polypeptide OTTMUSP00000074664 VEGA | MGI Sequence Detail 255 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    234 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:60484 Nguyen HV, et al., Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. J Physiol. 2000 Feb 15;523 Pt 1:139-46
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory