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Klk4 Gene Detail
Summary
  • Symbol
    Klk4
  • Name
    kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
  • Synonyms
    ESMP1, KLK-L1, Prss17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861379
    NCBI Gene: 56640
  • Gene Overview
    MyGene.info: KLK4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43881172-43885804 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.35 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861379
protein coding gene Chr7:43881160-43885804 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032147
protein coding gene Chr7:43933023-43937667 (+)
A/J MGP_AJ_G0032132
protein coding gene Chr7:43014789-43019427 (+)
AKR/J MGP_AKRJ_G0032062
protein coding gene Chr7:44400811-44405455 (+)
BALB/cJ MGP_BALBcJ_G0032137
protein coding gene Chr7:43128673-43133311 (+)
C3H/HeJ MGP_C3HHeJ_G0031853
protein coding gene Chr7:44910001-44914645 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032621
protein coding gene Chr7:46143729-46148373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029644
protein coding gene Chr7:45144313-45149017 (+)
CAST/EiJ MGP_CASTEiJ_G0031183
protein coding gene Chr7:36102571-36109050 (+)
CBA/J MGP_CBAJ_G0031822
protein coding gene Chr7:47607180-47611824 (+)
DBA/2J MGP_DBA2J_G0031971
protein coding gene Chr7:42821611-42826271 (+)
FVB/NJ MGP_FVBNJ_G0031932
protein coding gene Chr7:42529643-42534287 (+)
LP/J MGP_LPJ_G0032050
protein coding gene Chr7:44658965-44664843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031968
protein coding gene Chr7:46537422-46542066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032641
protein coding gene Chr7:43533200-43537951 (+)
PWK/PhJ MGP_PWKPhJ_G0030904
protein coding gene Chr7:36274022-36278665 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030743
protein coding gene Chr7:31561488-31566078 (+)
WSB/EiJ MGP_WSBEiJ_G0031297
protein coding gene Chr7:44076474-44081119 (+)



Homology
more
  • Human Ortholog
    KLK4, kallikrein related peptidase 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KLK4, kallikrein related peptidase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AI2A1, ARM1, EMSP, EMSP1, kallikrein, KLK-L1, PRSS17, PSTS
  • Links
    NCBI Gene ID: 9622
    neXtProt AC: NX_Q9Y5K2
    UniProt: Q9Y5K2

  • Chr Location
    19q13.41; chr19:50906352-50910745 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KLK4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced enamel strength that leads to enamel fracturing, delayed postnatal growth, and decreased survival to maturity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56640 NCBI Gene Model | MGI Sequence Detail 4633 C57BL/6J ±  kb
    transcript NM_019928 RefSeq | MGI Sequence Detail 1249 C57BL/6  
    polypeptide Q9Z0M1 UniProt | EBI | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:60484 Nguyen HV, et al., Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. J Physiol. 2000 Feb 15;523 Pt 1:139-46
    • Latest
      J:245023 Cantu C, et al., A cytoplasmic role of Wnt/beta-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Sci Signal. 2017 Feb 07;10(465)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory