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Klk4
Gene Detail
 Symbol
Name
ID
Klk4
kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
MGI:1861379
Synonyms ESMP1, KLK-L1, Prss17
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:43881172-43885804 bp, + strand
From NCBI annotation of GRCm38

  4633 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Klk4

Human
homologs
Human Homolog KLK4, kallikrein-related peptidase 4
NCBI Gene ID 9622
neXtProt AC  NX_Q9Y5K2
Human Synonyms  AI2A1, ARM1, EMSP, EMSP1, kallikrein, KLK-L1, PRSS17, PSTS
Human Chr (Location)  19q13.41; chr19:50906352-50910738 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KLK4
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit reduced enamel strength that leads to enamel fracturing, delayed postnatal growth, and decreased survival to maturity.
 
Phenotype Images(4)
Interactions
Klk4 interacts with 57 markers (Mir18, Mir18b, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process amelogenesis, extracellular matrix disassembly, ...
Component cellular_component
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (3)   
Theiler Stages: 25, 27, 28
Assay TypeResults
Western blot 4
RT-PCR 10
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000006948 (Evidence)
Entrez Gene56640 (Evidence)
UniGene42080
DFCITC1589874
DoTSDT.40173471
NIA Mouse Gene IndexU008023
Consensus CDS ProjectCCDS21186.1
International Mouse Knockout Project StatusKlk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56640 NCBI Gene Model | MGI Sequence Detail 4633 C57BL/6J ±  kb
transcript NM_019928 RefSeq | MGI Sequence Detail 1237 Swiss Webster 
polypeptide NP_064312 RefSeq | MGI Sequence Detail 255 Swiss Webster 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(271 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009414 kallikrein-4
References (Earliest) J:60484 Nguyen HV, et al., Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. J Physiol. 2000 Feb 15;523 Pt 1:139-46
(Latest) J:184287 Duverger O, et al., Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J Biol Chem. 2012 Apr 6;287(15):12230-40
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory