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Klk4 Gene Detail
Summary
  • Symbol
    Klk4
  • Name
    kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)
  • Synonyms
    ESMP1, KLK-L1, Prss17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861379
    NCBI Gene: 56640
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43530584-43535228 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.35 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861379
 protein coding gene Chr7:43530584-43535228 (+)
129S1/SvImJ ENSMUSG00200023341
 protein coding gene Chr7:31116504-31121148 (+)
A/J ENSMUSG00195041832
 protein coding gene Chr7:35156568-35161206 (+)
AKR/J ENSMUSG00220049543
 protein coding gene Chr7:29454763-29459407 (+)
BALB/cJ ENSMUSG00180028487
 protein coding gene Chr7:32032067-32036705 (+)
C3H/HeJ ENSMUSG00175037570
 protein coding gene Chr7:32552441-32557085 (+)
C57BL/6NJ ENSMUSG00215036851
 protein coding gene Chr7:31822286-31826930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029644
 protein coding gene Chr7:45144313-45149017 (+)
CAST/EiJ ENSTCUG00005047415
 protein coding gene Chr7:35556484-35561184 (+)
CBA/J ENSMUSG00210048591
 protein coding gene Chr7:32929187-32933831 (+)
DBA/2J ENSMUSG00185042992
 protein coding gene Chr7:36802603-36807266 (+)
FVB/NJ ENSMUSG00205044011
 protein coding gene Chr7:32474404-32479048 (+)
JF1/MsJ ENSUMUG00000048257
 protein coding gene Chr7:41289690-41294354 (+)
LP/J ENSMUSG00230051509
 protein coding gene Chr7:42237378-42242020 (+)
NOD/ShiLtJ ENSMUSG00190049523
 protein coding gene Chr7:32796099-32800743 (+)
NZO/HlLtJ ENSMUSG00225012682
 protein coding gene Chr7:40448241-40452887 (+)
PWK/PhJ ENSLUMG00010042518
 protein coding gene Chr7:31728970-31733613 (+)
SPRET/EiJ ENSMSPG00010028427
 protein coding gene Chr7:31514609-31519186 (+)
WSB/EiJ ENSIUOG00005025289
 protein coding gene Chr7:33366474-33371119 (+)



Homology
more
  • Human Ortholog
    KLK4, kallikrein related peptidase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK4, kallikrein related peptidase 4
  • Synonyms
    AI2A1, ARM1, EMSP, EMSP1, kallikrein, KLK-L1, PRSS17, PSTS
  • Links
    NCBI Gene ID: 9622
    UniProt: Q9Y5K2

  • Chr Location
    19q13.41; chr19:50906351-50911395 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KLK4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced enamel strength that leads to enamel fracturing, delayed postnatal growth, and decreased survival to maturity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    12
  • cDNA Data
    8
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56640 NCBI Gene Model | MGI Sequence Detail 4645 C57BL/6J ±  kb
    transcript NM_019928 RefSeq | MGI Sequence Detail 1249 ZRU/MplStud  
    polypeptide Q9Z0M1 UniProt | EBI | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 3
      Other 1
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:60484 Nguyen HV, et al., Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. J Physiol. 2000 Feb 15;523 Pt 1:139-46
    • Latest
      J:371029 Lamprou A, et al., Notch2 Deletion Compromises Epithelial Integrity and Enamel Formation in Rodent Incisors. Cells. 2025 Aug 7;14(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory