Klk4
Gene Detail

Symbol Name ID

Klk4 kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) MGI:1861379

Synonyms

ESMP1, KLK-L1, Prss17

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:43881172-43885804 bp, + strand From NCBI annotation of GRCm38   4633 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Klk4 ± 2 cM)

Protein SuperFamily: trypsin
Gene Tree: Klk4

Human ortholog

KLK4 kallikrein-related peptidase 4 NCBI Gene ID 9622
Human Synonyms: AI2A1, ARM1, EMSP, EMSP1, kallikrein, KLK-L1, PRSS17, PSTS
Human Chr19:51409608-51413994 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human KLK4 (1)

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele exhibit reduced enamel strength that leads to enamel fracturing, delayed postnatal growth, and decreased survival to maturity.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	amelogenesis, proteolysis
Component	cellular_component
Function	hydrolase activity, peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (2)   
Theiler Stages: 25, 28

Assay Type	Results
Western blot	4
RT-PCR	10

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000006948 (Evidence)
Entrez Gene	56640 (Evidence)
UniGene	42080
DFCI	TC1589874
DoTS	DT.40173471
NIA Mouse Gene Index	U008023
Consensus CDS Project	CCDS21186.1
International Mouse Knockout Project Status	Klk4

Sequences

Length	Strain/Species
genomic	56640	NCBI Gene Model | MGI Sequence Detail	4633	C57BL/6J
transcript	NM_019928	RefSeq | MGI Sequence Detail	1237	Swiss Webster
polypeptide	NP_064312	RefSeq | MGI Sequence Detail	255	Swiss Webster

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site

References

(Earliest) J:60484 Nguyen HV, et al., Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient mice. J Physiol. 2000 Feb 15;523 Pt 1:139-46
(Latest) J:184287 Duverger O, et al., Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J Biol Chem. 2012 Apr 6;287(15):12230-40
All references(35)