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Fgf21 Gene Detail
Summary
  • Symbol
    Fgf21
  • Name
    fibroblast growth factor 21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861377
    NCBI Gene: 56636
  • Gene Overview
    MyGene.info: FGF21
Location & Maps
more
  • Sequence Map
    Chr7:45613886-45615490 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1605 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.38 cM, cytoband B2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FGF21, fibroblast growth factor 21
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FGF21, fibroblast growth factor 21
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 26291
    neXtProt AC: NX_Q9NSA1

  • Chr Location
    19q13.33; chr19:48755559-48758330 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 6 alleles in 6 genetic backgrounds
    25 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    9
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058294 VEGA Gene Model | MGI Sequence Detail 1605 C57BL/6J ±  kb
transcript OTTMUST00000143156 VEGA | MGI Sequence Detail 951 Not Applicable  
polypeptide OTTMUSP00000074637 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 7
    Primer pair 4
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 103
    Developmental Gene Expression 19
    Gene Ontology 5
    Phenotypes 44
  • Earliest
    J:63008 Nishimura T, et al., Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
  • Latest
    J:234198 Jager J, et al., The Nuclear Receptor Rev-erbalpha Regulates Adipose Tissue-specific FGF21 Signaling. J Biol Chem. 2016 May 13;291(20):10867-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory