About   Help   FAQ
Fgf21
Gene Detail
 Symbol
Name
ID
Fgf21
fibroblast growth factor 21
MGI:1861377
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.38 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45613907-45615490 bp, - strand
From Ensembl annotation of GRCm38

  1584 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: fibroblast growth factor, 15/19/21 types
Gene Tree: Fgf21

Human
homologs
Human Homolog FGF21, fibroblast growth factor 21
NCBI Gene ID 26291
neXtProt AC  NX_Q9NSA1
Human Chr (Location)  19q13.33; chr19:48755559-48758330 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.
 
Interactions
Fgf21 interacts with 13 markers (Mir99a, Mir99b, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process fibroblast growth factor receptor signaling pathway, positive regulation of cell proliferation, ...
Component extracellular region
Function fibroblast growth factor receptor binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (192)    Tissues (178)    Images (16)
Theiler Stages: 15, 17, 19, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 176
Northern blot 6
RT-PCR 10
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(7) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030827 (Evidence)
Entrez Gene56636 (Evidence)
UniGene143736
DFCITC1586972
DoTSDT.60105072
NIA Mouse Gene IndexU028536
Consensus CDS ProjectCCDS21253.1
International Mouse Knockout Project StatusFgf21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030827 Ensembl Gene Model | MGI Sequence Detail 1584 C57BL/6J ±  kb
transcript ENSMUST00000033099 Ensembl | MGI Sequence Detail 930 Not Applicable 
polypeptide ENSMUSP00000033099 Ensembl | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007491 fibroblast growth factor 21
References (Earliest) J:63008 Nishimura T, et al., Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
(Latest) J:211483 Keipert S, et al., Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E469-82
All references(74)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory