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Fgf21
Gene Detail
Symbol

Name
ID
Fgf21
fibroblast growth factor 21
MGI:1861377
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.38 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:45613907-45615490 bp, - strand
From Ensembl annotation of GRCm38

  1584 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: FGF21
Protein SuperFamily: fibroblast growth factor, 15/19/21 types
Gene Tree: Fgf21

Human
homologs
FGF21, fibroblast growth factor 21
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26291
neXtProt AC: NX_Q9NSA1

Human Chr (Location): 19q13.33; chr19:48755559-48758330 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(9) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.
 
Interactions
Fgf21 interacts with 13 markers (Mir99a, Mir99b, Mir100, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (17 records)
Data Summary: Results (192)    Tissues (178)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 176
Northern blot 6
RT-PCR 10
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(7) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030827 (Evidence)
Entrez Gene 56636 (Evidence)
UniGene 143736
DFCI TC1586972
DoTS DT.60105072
NIA Mouse Gene Index U028536
Consensus CDS Project CCDS21253.1
International Mouse Phenotyping Consortium Status Fgf21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030827 Ensembl Gene Model | MGI Sequence Detail 1584 C57BL/6J ±  kb
transcript ENSMUST00000033099 Ensembl | MGI Sequence Detail 930 Not Applicable 
polypeptide ENSMUSP00000033099 Ensembl | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007491 fibroblast growth factor 21
References
(Earliest) J:63008 Nishimura T, et al., Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
(Latest) J:222169 Assini JM, et al., Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21. Endocrinology. 2015 Jun;156(6):2087-102
All references(88)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory