Fgf21
Gene Detail

Symbol Name ID

Fgf21 fibroblast growth factor 21 MGI:1861377

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.38 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:45613907-45615490 bp, - strand From Ensembl annotation of GRCm38   1584 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: fibroblast growth factor, 15/19/21 types
Gene Tree: Fgf21

Human homologs

Human Homolog		FGF21, fibroblast growth factor 21
NCBI Gene ID		26291
neXtProt AC		NX_Q9NSA1
Human Chr (Location)		19q13.33; chr19:49259344-49261582 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	positive regulation of cell proliferation, positive regulation of ERK1 and ERK2 cascade, ...
Component	extracellular region
Function	fibroblast growth factor receptor binding, growth factor activity

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (143)    Tissues (129)    Images (14)
Theiler Stages: 15, 17, 19, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	127
Northern blot	6
RT-PCR	10

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(7) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030827 (Evidence)
Entrez Gene	56636 (Evidence)
UniGene	143736
DFCI	TC1586972
DoTS	DT.60105072
NIA Mouse Gene Index	U028536
Consensus CDS Project	CCDS21253.1
International Mouse Knockout Project Status	Fgf21

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030827	Ensembl Gene Model | MGI Sequence Detail	1584	C57BL/6J
transcript	ENSMUST00000033099	Ensembl | MGI Sequence Detail	930	Not Applicable
polypeptide	ENSMUSP00000033099	Ensembl | MGI Sequence Detail	210	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR017338	Fibroblast growth factor, 15/19/21
InterPro	IPR002209	Heparin-binding growth factor/Fibroblast growth factor
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007491	fibroblast growth factor 21

References

(Earliest) J:63008 Nishimura T, et al., Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(60)