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Fgf21 Gene Detail
Summary
  • Symbol
    Fgf21
  • Name
    fibroblast growth factor 21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861377
    NCBI Gene: 56636
  • Gene Overview
    MyGene.info: FGF21
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:45613886-45615490 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.38 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861377
protein coding gene Chr7:45613886-45619350 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032232
protein coding gene Chr7:45913732-45915314 (-)
A/J MGP_AJ_G0032211
protein coding gene Chr7:45008053-45009636 (-)
AKR/J MGP_AKRJ_G0032147
protein coding gene Chr7:46257003-46258586 (-)
BALB/cJ MGP_BALBcJ_G0032223
protein coding gene Chr7:45001408-45002991 (-)
C3H/HeJ MGP_C3HHeJ_G0031938
protein coding gene Chr7:46747887-46749469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032715
protein coding gene Chr7:48168081-48169664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029729
protein coding gene Chr7:47553158-47554729 (-)
CAST/EiJ MGP_CASTEiJ_G0031267
protein coding gene Chr7:38186073-38187655 (-)
CBA/J MGP_CBAJ_G0031903
protein coding gene Chr7:49768006-49769589 (-)
DBA/2J MGP_DBA2J_G0032061
protein coding gene Chr7:44686070-44687652 (-)
FVB/NJ MGP_FVBNJ_G0032012
protein coding gene Chr7:44458682-44460265 (-)
LP/J MGP_LPJ_G0032139
protein coding gene Chr7:46618069-46619651 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032049
protein coding gene Chr7:48456169-48457752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032731
protein coding gene Chr7:45466910-45468496 (-)
PWK/PhJ MGP_PWKPhJ_G0030989
protein coding gene Chr7:38053929-38055511 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030827
protein coding gene Chr7:33494878-33496457 (-)
WSB/EiJ MGP_WSBEiJ_G0031384
protein coding gene Chr7:45971152-45972735 (-)



Homology
more
  • Human Ortholog
    FGF21, fibroblast growth factor 21
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FGF21, fibroblast growth factor 21
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 26291
    neXtProt AC: NX_Q9NSA1
    UniProt: Q9NSA1

  • Chr Location
    19q13.33; chr19:48755559-48758330 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 7 alleles in 7 genetic backgrounds
    25 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030827 Ensembl Gene Model | MGI Sequence Detail 1605 C57BL/6J ±  kb
    transcript ENSMUST00000033099 Ensembl | MGI Sequence Detail 951 Not Applicable  
    polypeptide ENSMUSP00000033099 Ensembl | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 8
      Primer pair 5
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 21
      Gene Ontology 6
      Phenotypes 77
    • Earliest
      J:63008 Nishimura T, et al., Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
    • Latest
      J:266076 Ruan CC, et al., A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21. Cell Metab. 2018 Sep 4;28(3):476-489.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory