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Fgf21 Gene Detail
Summary
  • Symbol
    Fgf21
  • Name
    fibroblast growth factor 21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861377
    NCBI Gene: 56636
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45263314-45264914 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.38 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861377
 protein coding gene Chr7:45263310-45264914 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032232
 protein coding gene Chr7:45913732-45915314 (-)
A/J MGP_AJ_G0032211
 protein coding gene Chr7:45008053-45009636 (-)
AKR/J MGP_AKRJ_G0032147
 protein coding gene Chr7:46257003-46258586 (-)
BALB/cJ MGP_BALBcJ_G0032223
 protein coding gene Chr7:45001408-45002991 (-)
C3H/HeJ MGP_C3HHeJ_G0031938
 protein coding gene Chr7:46747887-46749469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032715
 protein coding gene Chr7:48168081-48169664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029729
 protein coding gene Chr7:47553158-47554729 (-)
CAST/EiJ MGP_CASTEiJ_G0031267
 protein coding gene Chr7:38186073-38187655 (-)
CBA/J MGP_CBAJ_G0031903
 protein coding gene Chr7:49768006-49769589 (-)
DBA/2J MGP_DBA2J_G0032061
 protein coding gene Chr7:44686070-44687652 (-)
FVB/NJ MGP_FVBNJ_G0032012
 protein coding gene Chr7:44458682-44460265 (-)
LP/J MGP_LPJ_G0032139
 protein coding gene Chr7:46618069-46619651 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032049
 protein coding gene Chr7:48456169-48457752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032731
 protein coding gene Chr7:45466910-45468496 (-)
PWK/PhJ MGP_PWKPhJ_G0030989
 protein coding gene Chr7:38053929-38055511 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030827
 protein coding gene Chr7:33494878-33496457 (-)
WSB/EiJ MGP_WSBEiJ_G0031384
 protein coding gene Chr7:45971152-45972735 (-)



Homology
more
  • Human Ortholog
    FGF21, fibroblast growth factor 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF21, fibroblast growth factor 21
  • Links
    NCBI Gene ID: 26291
    neXtProt AC: NX_Q9NSA1
    UniProt: Q9NSA1

  • Chr Location
    19q13.33; chr19:48755524-48758333 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 7 alleles in 7 genetic backgrounds
    25 phenotypes from multigenic genotypes
    170 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased circulating glucose levels, oxygen consumption, and gluconeogenesis in fasted mice and increased circulating ketone levels in fed mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    961
  • Tissues
    205
  • cDNA Data
    8
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56636 NCBI Gene Model | MGI Sequence Detail 1601 C57BL/6J ±  kb
    transcript NM_020013 RefSeq | MGI Sequence Detail 947 C57BL/6  
    polypeptide Q9JJN1 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 8
      Primer pair 7
      Other 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 319
      Developmental Gene Expression 28
      Gene Ontology 7
      Phenotypes 170
    • Earliest
      J:63008 Nishimura T, et al., Identification of a novel FGF, FGF-21, preferentially expressed in the liver(1). Biochim Biophys Acta. 2000 Jun 21;1492(1):203-6
    • Latest
      J:346020 Bjorkman SH, et al., ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms. Sci Rep. 2024 Jan 18;14(1):1563
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory