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Slc15a1
Gene Detail
 Symbol
Name
ID
Slc15a1
solute carrier family 15 (oligopeptide transporter), member 1
MGI:1861376
Synonyms PECT1, PEPT1
Feature Type protein coding gene
Genetic Map
Chromosome 14
65.26 cM, cytoband E5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:121459621-121505254 bp, - strand
From NCBI annotation of GRCm38

  45634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38006  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: peptide transport protein PEPT1
Gene Tree: Slc15a1

Human
homologs
Human Homolog SLC15A1, solute carrier family 15 (oligopeptide transporter), member 1
NCBI Gene ID 6564
neXtProt AC  NX_P46059
Human Synonyms  HPECT1, HPEPT1, PEPT1
Human Chr (Location)  13q32.3; chr13:98683801-98752675 (-)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Targeted(4) Gene trapped(11)
 
Peptide uptake in the intestine is substantially reduced in mice homozygous for a null mutation of this gene.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of amino acid transport, oligopeptide transmembrane transport, ...
Component integral component of membrane, membrane
Function channel inhibitor activity, oligopeptide transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000025557 (Evidence)
Entrez Gene56643 (Evidence)
UniGene155618
DFCITC1587533
DoTSDT.101202177
NIA Mouse Gene IndexU035941
Consensus CDS ProjectCCDS37017.1
International Mouse Knockout Project StatusSlc15a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56643 NCBI Gene Model | MGI Sequence Detail 45634 C57BL/6J ±  kb
transcript NM_053079 RefSeq | MGI Sequence Detail 3123 C57BL/6 
polypeptide Q9JIP7 UniProt | EBI | MGI Sequence Detail 709 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(701 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004768 Oligopeptide transporter
InterPro IPR000109 Proton-dependent oligopeptide transporter family
InterPro IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
Protein Ontology PR:000014940 solute carrier family 15 member 1
Graphical View of Protein Domain Structure
References (Earliest) J:62996 Fei Y, et al., cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim Biophys Acta. 2000 Jun 21;1492(1):145-54
(Latest) J:204067 Diakogiannaki E, et al., Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia. 2013 Dec;56(12):2688-96
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory