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Apbb1ip Gene Detail
Summary
  • Symbol
    Apbb1ip
  • Name
    amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
  • Synonyms
    9930118P07Rik, proline-rich protein 48, Prp48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861354
    NCBI Gene: 54519
  • Gene Overview
    MyGene.info: APBB1IP
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:22774094-22875653 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 15.15 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861354
protein coding gene Chr2:22755989-22875653 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025392
protein coding gene Chr2:20505829-20611852 (+)
A/J MGP_AJ_G0025370
protein coding gene Chr2:19668159-19766363 (+)
AKR/J MGP_AKRJ_G0025339
protein coding gene Chr2:20380722-20483553 (+)
BALB/cJ MGP_BALBcJ_G0025365
protein coding gene Chr2:19782394-19880688 (+)
C3H/HeJ MGP_C3HHeJ_G0025126
protein coding gene Chr2:20282845-20387792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025809
protein coding gene Chr2:21103522-21208603 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023223
protein coding gene Chr2:18767940-18866637 (+)
CAST/EiJ MGP_CASTEiJ_G0024589
protein coding gene Chr2:20194237-20305668 (+)
CBA/J MGP_CBAJ_G0025104
protein coding gene Chr2:21903237-22012401 (+)
DBA/2J MGP_DBA2J_G0025237
protein coding gene Chr2:19569865-19671739 (+)
FVB/NJ MGP_FVBNJ_G0025199
protein coding gene Chr2:19357168-19457168 (+)
LP/J MGP_LPJ_G0025323
protein coding gene Chr2:20443367-20547809 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025230
protein coding gene Chr2:21945146-22059958 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025868
protein coding gene Chr2:20256371-20359325 (+)
PWK/PhJ MGP_PWKPhJ_G0024338
protein coding gene Chr2:19385548-19485143 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024138
protein coding gene Chr2:20378362-20488344 (+)
WSB/EiJ MGP_WSBEiJ_G0024659
protein coding gene Chr2:20389670-20510096 (+)



Homology
more
  • Human Ortholog
    APBB1IP, amyloid beta precursor protein binding family B member 1 interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APBB1IP, amyloid beta precursor protein binding family B member 1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INAG1, PREL1, RARP1, RIAM
  • Links
    NCBI Gene ID: 54518
    neXtProt AC: NX_Q7Z5R6
    UniProt: Q7Z5R6

  • Chr Location
    10p12.1; chr10:26438324-26567879 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and healthy with no apparent defects in platelet integrin activation and function, hemostasis, or arterial thrombus formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026786 Ensembl Gene Model | MGI Sequence Detail 101560 C57BL/6J ±  kb
transcript ENSMUST00000014290 Ensembl | MGI Sequence Detail 2773 Not Applicable  
polypeptide ENSMUSP00000014290 Ensembl | MGI Sequence Detail 670 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 4
Other
Accession IDs
less
MGI:2442489
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:44866 Ermekova KS, et al., The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997 Dec 26;272(52):32869-77
  • Latest
    J:247801 Lagarrigue F, et al., Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. J Immunol. 2017 May 01;198(9):3410-3415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory