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Fntb Gene Detail
Summary
  • Symbol
    Fntb
  • Name
    farnesyltransferase, CAAX box, beta
  • Synonyms
    2010013E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861305
    NCBI Gene: 110606
  • Gene Overview
    MyGene.info: FNTB
Location & Maps
more
  • Sequence Map
    Chr12:76765589-76921412 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      155824 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FNTB, farnesyltransferase, CAAX box, beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FNTB, farnesyltransferase, CAAX box, beta
    Orthology source: HomoloGene
  • Synonyms
    FPTB
  • Links
    NCBI Gene ID: 2342
    neXtProt AC: NX_P49356

  • Chr Location
    14q23.3; chr14:64986789-65062652 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    306
  • Chemically induced (other)
    1
  • Gene trapped
    298
  • Targeted
    7
  • Genomic Mutations
    1 involving Fntb
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit early embryonic lethality and loss epiblast-derived structures as a result of decreased cell proliferation and increased apoptosis. Cultured blastocysts corresponding to E7.5 embryos display a dramatic decrease in inner cell mass proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033888 VEGA Gene Model | MGI Sequence Detail 155824 C57BL/6J ±  kb
transcript OTTMUST00000085463 VEGA | MGI Sequence Detail 1442 Not Applicable  
polypeptide OTTMUSP00000046169 VEGA | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    638 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007592 protein farnesyltransferase subunit beta
  • PDB
  • EC
  • InterPro Domains
    IPR001330 PFTB repeat
    IPR026872 Protein farnesyltransferase subunit beta
    IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    IPR009508 Transcription activator, Churchill
Molecular
Reagents
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  • All nucleic 66
    cDNA 66

    Microarray probesets 3
Other
Accession IDs
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MGI:1917513, MGI:2144730
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:56486 Seldin MF, et al., Chromosomal mapping of Adam9, Adam15 and Adam21. Matrix Biol. 2000 May;19(2):185-7
  • Latest
    J:207213 Cheng S, et al., Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem. 2013 Dec 13;288(50):35952-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory