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Fntb
Gene Detail
 Symbol
Name
ID
Fntb
farnesyltransferase, CAAX box, beta
MGI:1861305
Synonyms 2010013E13Rik
Feature Type protein coding gene
Genetic Map
Chromosome 12
33.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:76765589-76921412 bp, + strand
From VEGA annotation of GRCm38

  155824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1535  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein prenyltransferase, FTase/GGTase types
Gene Tree: Fntb

Human
homologs
Human Homolog FNTB, farnesyltransferase, CAAX box, beta
NCBI Gene ID 2342
neXtProt AC  NX_P49356
Human Synonyms  FPTB
Human Chr (Location)  14q23.3; chr14:64986789-65062652 (+)  GRCh38
Alleles
and
phenotypes
All alleles(304) : Gene trapped(298) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit early embryonic lethality and loss epiblast-derived structures as a result of decreased cell proliferation and increased apoptosis. Cultured blastocysts corresponding to E7.5 embryos display a dramatic decrease in inner cell mass proliferation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process negative regulation of cell proliferation, positive regulation of cell cycle, ...
Component microtubule associated complex, protein complex, ...
Function catalytic activity, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033888 (Evidence)
Ensembl Gene ModelENSMUSG00000033373 (Evidence)
Entrez Gene110606 (Evidence)
UniGene151174
DFCITC1577012, TC1686918
DoTSDT.101280312, DT.97343700
NIA Mouse Gene IndexU014123
EC2.5.1.58
PDB3PZ4
Consensus CDS ProjectCCDS25998.1
International Mouse Knockout Project StatusFntb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033888 VEGA Gene Model | MGI Sequence Detail 155824 C57BL/6J ±  kb
transcript OTTMUST00000085463 VEGA | MGI Sequence Detail 1442 Not Applicable 
polypeptide OTTMUSP00000046169 VEGA | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(642 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001330 Prenyltransferase/squalene oxidase
InterPro IPR026872 Protein farnesyltransferase subunit beta
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
InterPro IPR009508 Transcription activator, Churchill
Protein Ontology PR:000007592 protein farnesyltransferase subunit beta
References (Earliest) J:56486 Seldin MF, et al., Chromosomal mapping of Adam9, Adam15 and Adam21. Matrix Biol. 2000 May;19(2):185-7
(Latest) J:207213 Cheng S, et al., Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem. 2013 Dec 13;288(50):35952-60
All references(43)
Other
accession IDs
MGI:1917513, MGI:2144730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory