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Adam21 Gene Detail
Summary
  • Symbol
    Adam21
  • Name
    a disintegrin and metallopeptidase domain 21
  • Synonyms
    ADAM31
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861229
    NCBI Gene: 56622
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81605358-81615248 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    214 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861229
 protein coding gene Chr12:81605349-81615248 (-)
129S1/SvImJ ENSMUSG00200047524
 protein coding gene Chr12:73575614-73585504 (-)
A/J ENSMUSG00195028351
 protein coding gene Chr12:76269325-76279215 (-)
AKR/J ENSMUSG00220047987
 protein coding gene Chr12:74064687-74074577 (-)
BALB/cJ ENSMUSG00180020426
 protein coding gene Chr12:75239907-75249798 (-)
C3H/HeJ ENSMUSG00175037850
 protein coding gene Chr12:78401415-78411304 (-)
C57BL/6NJ ENSMUSG00215044353
 protein coding gene Chr12:74605415-74615305 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017910
 protein coding gene Chr12:76000565-76010434 (-)
CAST/EiJ ENSTCUG00005028397
 protein coding gene Chr12:74542263-74552183 (-)
CBA/J ENSMUSG00210043684
 protein coding gene Chr12:74815632-74825521 (-)
DBA/2J ENSMUSG00185041241
 protein coding gene Chr12:76676455-76686344 (-)
FVB/NJ ENSMUSG00205026522
 protein coding gene Chr12:74418889-74428789 (-)
JF1/MsJ ENSUMUG00000031961
 protein coding gene Chr12:80673756-80683677 (-)
LP/J ENSMUSG00230042340
 protein coding gene Chr12:83693608-83703500 (-)
NOD/ShiLtJ ENSMUSG00190043406
 protein coding gene Chr12:73878772-73888674 (-)
NZO/HlLtJ ENSMUSG00225051973
 protein coding gene Chr12:85754675-85764577 (-)
PWK/PhJ ENSLUMG00010024310
 protein coding gene Chr12:74672019-74681927 (-)
SPRET/EiJ ENSMSPG00010016889
 protein coding gene Chr12:76508325-76518242 (-)
WSB/EiJ ENSIUOG00005042501
 protein coding gene Chr12:74487788-74497679 (-)



Homology
more
  • Human Ortholog
    ADAM21, ADAM metallopeptidase domain 21
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM21, ADAM metallopeptidase domain 21
  • Synonyms
    ADAM 21, ADAM31
  • Links
    NCBI Gene ID: 8747
    UniProt: Q9UKJ8

  • Chr Location
    14q24.2; chr14:70417107-70460427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    667
  • Tissues
    45
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000008438 Ensembl Gene Model | MGI Sequence Detail 9891 C57BL/6J ±  kb
transcript ENSMUST00000008582 Ensembl | MGI Sequence Detail 2911 Not Applicable  
polypeptide ENSMUSP00000008582 Ensembl | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:56486 Seldin MF, et al., Chromosomal mapping of Adam9, Adam15 and Adam21. Matrix Biol. 2000 May;19(2):185-7
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory