Adam21
Gene Detail

Symbol Name ID

Adam21 a disintegrin and metallopeptidase domain 21 MGI:1861229

Synonyms

ADAM31

Feature Type

protein coding gene

Genetic Map

Chromosome 12

37.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:81558584-81568474 bp, - strand From VEGA annotation of GRCm38   9891 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adam21 ± 2 cM)

Gene Tree: Adam21

Human ortholog

ADAM21 ADAM metallopeptidase domain 21 NCBI Gene ID 8747
Human Synonyms: ADAM 21, ADAM31
Human Chr14:70924217-70926622 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	proteolysis
Component	integral to membrane, membrane
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (69)    Tissues (45)    Images (2)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	31
RT-PCR	38

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000035333 (Evidence)
Ensembl Gene Model	ENSMUSG00000008438 (Evidence)
Entrez Gene	56622 (Evidence)
UniGene	117130
DFCI	TC1595980, TC1633105
DoTS	DT.40169809
NIA Mouse Gene Index	U034140
EC	3.4.24.-
Consensus CDS Project	CCDS26022.1
International Mouse Knockout Project Status	Adam21

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035333	VEGA Gene Model | MGI Sequence Detail	9891	C57BL/6J
transcript	OTTMUST00000090168	VEGA | MGI Sequence Detail	2911	Not Applicable
polypeptide	OTTMUSP00000049411	VEGA | MGI Sequence Detail	729	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR018358	Disintegrin, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000003717	disintegrin and metalloproteinase domain-containing protein 21

References

(Earliest) J:56486 Seldin MF, et al., Chromosomal mapping of Adam9, Adam15 and Adam21. Matrix Biol. 2000 May;19(2):185-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)