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Ubr3
Gene Detail
 Symbol
Name
ID
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
MGI:1861100
Synonyms 1110059H15Rik, 4833421P10Rik, A130030D10Rik, Zfp650
Feature Type protein coding gene
Genetic Map
Chromosome 2
40.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:69897246-70024013 bp, + strand
From VEGA annotation of GRCm38

  126768 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ubr3

Human
homologs
Human Homolog UBR3, ubiquitin protein ligase E3 component n-recognin 3 (putative)
NCBI Gene ID 130507
neXtProt AC  NX_Q6ZT12
Human Synonyms  ZNF650
Human Chr (Location)  2q31.1; chr2:169827508-170084131 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(36) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia.
 
Interactions
Ubr3 interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process embryo development, in utero embryonic development, ...
Component integral component of membrane, membrane
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
Expression
Literature Summary: (3 records)
Data Summary: Results (65)    Tissues (7)    Images (32)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 63
Northern blot 2
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(24) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000013114 (Evidence)
Ensembl Gene ModelENSMUSG00000044308 (Evidence)
Entrez Gene68795 (Evidence)
DFCITC1579427, TC1585211, TC1600533, TC1624295, TC1635244, TC1692157, TC1717157, TC1719070
DoTSDT.101297081, DT.101711862, DT.40161857, DT.491448, DT.534728, DT.55113897, DT.94178200, DT.97399127
NIA Mouse Gene IndexU001880, U286682
EC6.3.2.-
Consensus CDS ProjectCCDS16104.2
International Mouse Knockout Project StatusUbr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013114 VEGA Gene Model | MGI Sequence Detail 126768 C57BL/6J ±  kb
transcript OTTMUST00000031645 VEGA | MGI Sequence Detail 8072 Not Applicable 
polypeptide OTTMUSP00000014100 VEGA | MGI Sequence Detail 1889 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(18) UniProt(7)
Polymorphisms SNPs within 2kb(465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003126 Zinc finger, N-recognin
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000017014 E3 ubiquitin-protein ligase UBR3
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:1916045, MGI:1921167, MGI:2138772, MGI:2138774, MGI:2139027, MGI:2139158, MGI:3035300, MGI:3045343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory