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Ubr3
Gene Detail
Symbol

Name
ID
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
MGI:1861100
Synonyms
1110059H15Rik, 4833421P10Rik, A130030D10Rik, Zfp650
Feature Type
protein coding gene
Genetic Map
Chromosome 2
40.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:69897246-70024013 bp, + strand
From VEGA annotation of GRCm38

  126768 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBR3
Gene Tree: Ubr3

Human
homologs
UBR3, ubiquitin protein ligase E3 component n-recognin 3 (putative)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 130507
neXtProt AC: NX_Q6ZT12

Human Synonyms: ZNF650

Human Chr (Location): 2q31.1; chr2:169827470-170084131 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(36) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia.
 
Interactions
Ubr3 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (65)    Tissues (7)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 63
Northern blot 2
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA UBR3 ; Xenbase ubr3    NEW 
Molecular
reagents
All nucleic(32) cDNA(31) Other(1)
Microarray probesets(9)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013114 VEGA Gene Model | MGI Sequence Detail 126768 C57BL/6J ±  kb
transcript OTTMUST00000031645 VEGA | MGI Sequence Detail 8072 Not Applicable 
polypeptide OTTMUSP00000014100 VEGA | MGI Sequence Detail 1889 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(19) UniProt(6)
Polymorphisms
SNPs within 2kb(465 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003126 Zinc finger, N-recognin
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000017014 E3 ubiquitin-protein ligase UBR3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:1916045, MGI:1921167, MGI:2138772, MGI:2138774, MGI:2139027, MGI:2139158, MGI:3035300, MGI:3045343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory