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Ubr2 Gene Detail
Summary
  • Symbol
    Ubr2
  • Name
    ubiquitin protein ligase E3 component n-recognin 2
  • Synonyms
    9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861099
    NCBI Gene: 224826
  • Gene Overview
    MyGene.info: UBR2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46928295-47010556 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    567 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861099
protein coding gene Chr17:46928291-47010775 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023839
protein coding gene Chr17:48038531-48124518 (-)
A/J MGP_AJ_G0023797
protein coding gene Chr17:46873429-46954269 (-)
AKR/J MGP_AKRJ_G0023768
protein coding gene Chr17:47231550-47312337 (-)
BALB/cJ MGP_BALBcJ_G0023801
protein coding gene Chr17:46773516-46858107 (-)
C3H/HeJ MGP_C3HHeJ_G0023564
protein coding gene Chr17:47975764-48059156 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024244
protein coding gene Chr17:50091782-50177356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021694
protein coding gene Chr17:43638183-43721262 (-)
CAST/EiJ MGP_CASTEiJ_G0023046
protein coding gene Chr17:48075137-48159768 (-)
CBA/J MGP_CBAJ_G0023541
protein coding gene Chr17:51916885-52006250 (-)
DBA/2J MGP_DBA2J_G0023667
protein coding gene Chr17:45635038-45716633 (-)
FVB/NJ MGP_FVBNJ_G0023634
protein coding gene Chr17:45268645-45352889 (-)
LP/J MGP_LPJ_G0023748
protein coding gene Chr17:48712841-48797978 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023663
protein coding gene Chr17:51435459-51518209 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024289
protein coding gene Chr17:47595320-47680121 (-)
PWK/PhJ MGP_PWKPhJ_G0022790
protein coding gene Chr17:44984030-45066774 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022606
protein coding gene Chr17:44482693-44567489 (-)
WSB/EiJ MGP_WSBEiJ_G0023111
protein coding gene Chr17:48159425-48244736 (-)



Homology
more
  • Human Ortholog
    UBR2, ubiquitin protein ligase E3 component n-recognin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBR2, ubiquitin protein ligase E3 component n-recognin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA49A4.1, C6orf133, dJ242G1.1, dJ392M17.3
  • Links
    NCBI Gene ID: 23304
    neXtProt AC: NX_Q8IWV8
    UniProt: Q8IWV8

  • Chr Location
    6p21.1; chr6:42563905-42693505 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 26151
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBR2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 4 genetic backgrounds
    24 phenotypes from multigenic genotypes
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023977 Ensembl Gene Model | MGI Sequence Detail 82262 C57BL/6J ±  kb
    transcript ENSMUST00000113335 Ensembl | MGI Sequence Detail 5691 Not Applicable  
    polypeptide ENSMUSP00000108961 Ensembl | MGI Sequence Detail 1755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923986, MGI:1925978, MGI:2139370, MGI:2146871, MGI:3704478
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:62140 Kwon YT, et al., Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Mol Cell Biol. 2000 Jun;20(11):4135-48
    • Latest
      J:254446 Mao J, et al., UBR2 Enriched in p53 Deficient Mouse Bone Marrow Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/beta-Catenin Pathway. Stem Cells. 2017 Nov;35(11):2267-2279

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory