Chdh MGI Mouse Gene Detail - MGI:1860776

Symbol

Chdh
Name

choline dehydrogenase
Synonyms

D630034H06Rik, MGC:30702

Feature Type

protein coding gene
IDs

MGI:1860776
NCBI Gene: 218865
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr14:29730957-29762423 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.40 cM
Mapping Data

3 experiments

SNPs within 2kb

287 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860776	protein coding gene	Chr14:29730957-29762484 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021101	protein coding gene	Chr14:23113684-23145156 (+)
A/J	MGP_AJ_G0021049	protein coding gene	Chr14:22242296-22273687 (+)
AKR/J	MGP_AKRJ_G0021026	protein coding gene	Chr14:23335830-23367211 (+)
BALB/cJ	MGP_BALBcJ_G0021053	protein coding gene	Chr14:22334849-22366426 (+)
C3H/HeJ	MGP_C3HHeJ_G0020836	protein coding gene	Chr14:23196042-23227487 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021485	protein coding gene	Chr14:24032163-24063596 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019048	protein coding gene	Chr14:22313856-22347171 (+)
CAST/EiJ	MGP_CASTEiJ_G0020361	protein coding gene	Chr14:22915300-22947164 (+)
CBA/J	MGP_CBAJ_G0020803	protein coding gene	Chr14:24957860-24989273 (+)
DBA/2J	MGP_DBA2J_G0020925	protein coding gene	Chr14:22286084-22317676 (+)
FVB/NJ	MGP_FVBNJ_G0020909	protein coding gene	Chr14:22234341-22265734 (+)
LP/J	MGP_LPJ_G0020994	protein coding gene	Chr14:23433265-23464708 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020935	protein coding gene	Chr14:24268641-24299992 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021518	protein coding gene	Chr14:23091984-23123423 (+)
PWK/PhJ	MGP_PWKPhJ_G0020109	protein coding gene	Chr14:21711312-21744300 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019933	protein coding gene	Chr14:22654699-22683117 (+)
WSB/EiJ	MGP_WSBEiJ_G0020416	protein coding gene	Chr14:23149689-23181103 (+)

Human Ortholog

CHDH, choline dehydrogenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHDH, choline dehydrogenase
Links

HGNC:24288

NCBI Gene ID: 55349

neXtProt AC: NX_Q8NE62

UniProt: Q8NE62
Chr Location

3p21.1; chr3:53813130-53846393 (-) GRCh38.p7

Alliance of Genome Resources

Chdh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHDH
Protein SuperFamily

Alcohol_oxidase
Gene Tree

Chdh

less

Phenotype Summary

11 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous male mutants show reduced fertility due to reduced sperm motility caused by abnormal mitochondrial function and structures.

less

All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

129
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

Chdh interacts with 342 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

less

All Sequences

44
RefSeq

7
UniProt

3
CCDS

CCDS26892.1

Ensembl

ENSMUSG00000015970 (Evidence)
NCBI Gene

218865

			Length	Strain/Species	Flank
genomic	218865	NCBI Gene Model \| MGI Sequence Detail	31467	C57BL/6J	± kb
transcript	NM_001136240	RefSeq \| MGI Sequence Detail	5652	C57BL/6
polypeptide	Q8BJ64	UniProt \| EBI \| MGI Sequence Detail	596	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000005416 choline dehydrogenase, mitochondrial

(term hierarchy)
EC

1.1.99.1
InterPro Domains

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR012132 Glucose-methanol-choline oxidoreductase

IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal

IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal

IPR027424 Glucose Oxidase, domain 2

IPR011533 Oxygen-dependent choline dehydrogenase

less

All nucleic 11

Genomic 1

cDNA 9

Primer pair 1

Microarray probesets 2

less

MGI:2145756

Summaries

All 37

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:312368 Imbard A, et al., Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Sci Rep. 2021 Oct 26;11(1):21132

TSS for Chdh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124809	Chr14:29730850-29730858 (+)	-103 bp
Tssr124810	Chr14:29730886-29730901 (+)	-63 bp
Tssr124811	Chr14:29730907-29730918 (+)	-44 bp
Tssr124812	Chr14:29730975-29730987 (+)	24 bp
Tssr124813	Chr14:29730993-29731014 (+)	47 bp
Tssr124814	Chr14:29731033-29731049 (+)	84 bp
Tssr124815	Chr14:29731052-29731067 (+)	103 bp
Tssr124816	Chr14:29731072-29731103 (+)	131 bp
Tssr124817	Chr14:29731119-29731131 (+)	168 bp
Tssr124818	Chr14:29732042-29732056 (+)	1,092 bp
Tssr124819	Chr14:29732280-29732300 (+)	1,333 bp
Tssr124820	Chr14:29737434-29737453 (+)	6,487 bp
Tssr124821	Chr14:29744707-29744733 (+)	13,763 bp
Tssr124822	Chr14:29746904-29746911 (+)	15,951 bp
Tssr124823	Chr14:29747620-29747633 (+)	16,670 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20