Chdh MGI Mouse Gene Detail - MGI:1860776

Chdh Gene Detail

Symbol

Chdh
Name

choline dehydrogenase
Synonyms

D630034H06Rik, MGC:30702

Feature Type

protein coding gene
IDs

MGI:1860776
NCBI Gene: 218865

Sequence Map

Chr14:30009023-30040466 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

31444 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.40 cM
Mapping Data

3 experiments

Human Ortholog

CHDH, choline dehydrogenase

Vertebrate Orthologs

9

Human Ortholog

CHDH, choline dehydrogenase
Orthology source: HomoloGene, HGNC
Links

HGNC:24288

NCBI Gene ID: 55349

neXtProt AC: NX_Q8NE62

UniProt: Q8NE62
Chr Location

3p21.1; chr3:53813130-53846393 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41261
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: CHDH
Protein SuperFamily

glucose-methanol-choline oxidoreductase
Gene Tree

Chdh

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available

Homozygous male mutants show reduced fertility due to reduced sperm motility caused by abnormal mitochondrial function and structures.

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All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

126
Tissues

100
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Chdh interacts with 342 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

32
RefSeq

7
UniProt

3
CCDS

CCDS26892.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000027809	VEGA Gene Model \| MGI Sequence Detail	31444	C57BL/6J	± kb
transcript	OTTMUST00000068821	VEGA \| MGI Sequence Detail	5629	Not Applicable
polypeptide	OTTMUSP00000034869	VEGA \| MGI Sequence Detail	596	Not Applicable

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SNPs within 2kb

296 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000005416 choline dehydrogenase, mitochondrial

(term hierarchy)
EC

1.1.99.1
InterPro Domains

IPR023753 FAD/NAD(P)-binding domain

IPR012132 Glucose-methanol-choline oxidoreductase

IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal

IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal

IPR011533 Oxygen-dependent choline dehydrogenase

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All nucleic 9

Genomic 1

cDNA 8

Microarray probesets 2

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MGI:2145756

Summaries

All 31

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 4
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:236231 Nishihara H, et al., Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate. PLoS Genet. 2016 Oct;12(10):e1006380

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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