Chdh
Gene Detail

Symbol

Name
ID

Chdh
choline dehydrogenase
MGI:1860776

Synonyms

D630034H06Rik, MGC:30702

Feature Type

protein coding gene

Genetic Map

Chromosome 14
18.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:30009023-30040466 bp, + strand From VEGA annotation of GRCm38   31444 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:41261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glucose-methanol-choline oxidoreductase
Gene Tree: Chdh

Human
homologs

Human Homolog		CHDH, choline dehydrogenase
NCBI Gene ID		55349
neXtProt AC		NX_Q8NE62
Human Chr (Location)		3p21.1; chr3:53816297-53846393 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous male mutants show reduced fertility due to reduced sperm motility caused by abnormal mitochondrial function and structures.

 

Interactions

Chdh interacts with 343 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (10 annotations)

Process	glycine betaine biosynthetic process from choline, oxidation-reduction process
Component	membrane, mitochondrial inner membrane, ...
Function	choline dehydrogenase activity, flavin adenine dinucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (126)    Tissues (100)    Images (30)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	126

cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000027809 (Evidence)
Ensembl Gene Model	ENSMUSG00000015970 (Evidence)
Entrez Gene	218865 (Evidence)
NIA Mouse Gene Index	U015435
EC	1.1.99.1
Consensus CDS Project	CCDS26892.1
International Mouse Knockout Project Status	Chdh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027809	VEGA Gene Model | MGI Sequence Detail	31444	C57BL/6J
transcript	OTTMUST00000068821	VEGA | MGI Sequence Detail	5629	Not Applicable
polypeptide	OTTMUSP00000034869	VEGA | MGI Sequence Detail	596	Not Applicable

All sequences(35) RefSeq(7) UniProt(5)

Polymorphisms

SNPs within 2kb(296 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR011533	Choline dehydrogenase
InterPro	IPR012132	Glucose-methanol-choline oxidoreductase
InterPro	IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal
InterPro	IPR000172	Glucose-methanol-choline oxidoreductase, N-terminal
Protein Ontology	PR:000005416	choline dehydrogenase, mitochondrial

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Other
accession IDs

MGI:2145756