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Chdh Gene Detail
Summary
  • Symbol
    Chdh
  • Name
    choline dehydrogenase
  • Synonyms
    D630034H06Rik, MGC:30702
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860776
    NCBI Gene: 218865
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:30009023-30040466 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      31444 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.40 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CHDH, choline dehydrogenase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHDH, choline dehydrogenase
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 55349
    neXtProt AC: NX_Q8NE62
    UniProt: Q8NE62

  • Chr Location
    3p21.1; chr3:53813130-53846393 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous male mutants show reduced fertility due to reduced sperm motility caused by abnormal mitochondrial function and structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    126
  • Tissues
    100
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027809 VEGA Gene Model | MGI Sequence Detail 31444 C57BL/6J ±  kb
    transcript OTTMUST00000068821 VEGA | MGI Sequence Detail 5629 Not Applicable  
    polypeptide OTTMUSP00000034869 VEGA | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      296 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 9

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145756
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:245852 McClatchie T, et al., Betaine is accumulated via transient choline dehydrogenase activation during mouse oocyte meiotic maturation. J Biol Chem. 2017 Aug 18;292(33):13784-13794
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory