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Gucy1b3
Gene Detail
 Symbol
Name
ID
Gucy1b3
guanylate cyclase 1, soluble, beta 3
MGI:1860604
Synonyms beta 1 sGC
Feature Type protein coding gene
Genetic Map
Chromosome 3
35.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:82032004-82074711 bp, - strand
From NCBI annotation of GRCm38

  42708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: soluble guanylate cyclase
Gene Tree: Gucy1b3

Human
homologs
Human Homolog GUCY1B3, guanylate cyclase 1, soluble, beta 3
NCBI Gene ID 2983
neXtProt AC  NX_Q02153
Human Synonyms  GC-SB3, GC-S-beta-1, GUC1B3, GUCB3, GUCSB3, GUCY1B1
Human Chr (Location)  4q31.3-q33; chr4:155758974-155807631 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice that bypass neonatal lethality die prematurely due to severe gastrointestinal obstruction and exhibit hypertension, reduced heart rate, lack of glycerol trinitrate-induced drop in systolic pressure, and lack of a nitric oxide effect on aortic relaxation and platelet aggregation.
 
Phenotype Images(2)
Interactions
Gucy1b3 interacts with 222 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component cytoplasm, guanylate cyclase complex, soluble, ...
Function GTP binding, guanylate cyclase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (399)    Tissues (131)    Images (39)
Theiler Stages: 20, 22, 23
Assay TypeResults
RNA in situ 397
RT-PCR 2
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000028005 (Evidence)
Entrez Gene54195 (Evidence)
DFCITC1578457, TC1596647
DoTSDT.101388370, DT.526512
NIA Mouse Gene IndexU024188
EC4.6.1.2
Consensus CDS ProjectCCDS38460.1
International Mouse Knockout Project StatusGucy1b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54195 NCBI Gene Model | MGI Sequence Detail 42708 C57BL/6J ±  kb
transcript NM_017469 RefSeq | MGI Sequence Detail 3251 C57BL/6 
polypeptide O54865 UniProt | EBI | MGI Sequence Detail 620 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR011645 Haem NO binding associated
InterPro IPR011644 Heme-NO binding
InterPro IPR024096 NO signalling/Golgi transport ligand-binding domain
Protein Ontology PR:000008351 guanylate cyclase soluble subunit beta-1
Graphical View of Protein Domain Structure
References (Earliest) J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
(Latest) J:205095 Groneberg D, et al., Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor. J Physiol. 2013 Jan 15;591(Pt 2):491-502
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory