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Gucy1b1 Gene Detail
Summary
  • Symbol
    Gucy1b1
  • Name
    guanylate cyclase 1, soluble, beta 1
  • Synonyms
    beta 1 sGC, Gucy1b3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860604
    NCBI Gene: 54195
  • Gene Overview
    MyGene.info: GUCY1B1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82032006-82074689 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860604
protein coding gene Chr3:82032004-82074711 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027325
protein coding gene Chr3:81827683-81871429 (-)
A/J MGP_AJ_G0027287
protein coding gene Chr3:79119921-79163249 (-)
AKR/J MGP_AKRJ_G0027255
protein coding gene Chr3:80988458-81031300 (-)
BALB/cJ MGP_BALBcJ_G0027298
protein coding gene Chr3:79220285-79263415 (-)
C3H/HeJ MGP_C3HHeJ_G0027042
protein coding gene Chr3:81278563-81321151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027744
protein coding gene Chr3:84933785-84981104 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025097
protein coding gene Chr3:74888407-74930125 (-)
CAST/EiJ MGP_CASTEiJ_G0026489
protein coding gene Chr3:81455832-81500143 (-)
CBA/J MGP_CBAJ_G0027017
protein coding gene Chr3:87776962-87819573 (-)
DBA/2J MGP_DBA2J_G0027153
protein coding gene Chr3:78681638-78724342 (-)
FVB/NJ MGP_FVBNJ_G0027121
protein coding gene Chr3:76968514-77013684 (-)
LP/J MGP_LPJ_G0027261
protein coding gene Chr3:82829678-82874066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027140
protein coding gene Chr3:94158334-94201901 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027802
protein coding gene Chr3:80791772-80834445 (-)
PWK/PhJ MGP_PWKPhJ_G0026223
protein coding gene Chr3:78412363-78455575 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026039
protein coding gene Chr3:80007696-80050827 (-)
WSB/EiJ MGP_WSBEiJ_G0026567
protein coding gene Chr3:81140515-81181823 (-)



Homology
more
  • Human Ortholog
    GUCY1B1, guanylate cyclase 1 soluble subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GUCY1B1, guanylate cyclase 1 soluble subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GC-SB3, GC-S-beta-1, GUC1B3, GUCB3, GUCSB3, GUCY1B3
  • Links
    NCBI Gene ID: 2983
    neXtProt AC: NX_Q02153
    UniProt: Q02153

  • Chr Location
    4q32.1; chr4:155758973-155807642 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 5 genetic backgrounds
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice that bypass neonatal lethality die prematurely due to severe gastrointestinal obstruction and exhibit hypertension, reduced heart rate, lack of glycerol trinitrate-induced drop in systolic pressure, and lack of a nitric oxide effect on aortic relaxation and platelet aggregation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028005 Ensembl Gene Model | MGI Sequence Detail 42684 C57BL/6J ±  kb
    transcript ENSMUST00000029635 Ensembl | MGI Sequence Detail 3223 Not Applicable  
    polypeptide ENSMUSP00000029635 Ensembl | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR011645 Haem NO binding associated
      IPR011644 Heme NO-binding
      IPR038158 H-NOX domain superfamily
      IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
      IPR029787 Nucleotide cyclase
    Molecular
    Reagents
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    • All nucleic 10
      Genomic 1
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
    • Latest
      J:233458 Hoffmann LS, et al., Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat Commun. 2015;6:7235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory