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Gucy1b1 Gene Detail
Summary
  • Symbol
    Gucy1b1
  • Name
    guanylate cyclase 1, soluble, beta 1
  • Synonyms
    beta 1 sGC, Gucy1b3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860604
    NCBI Gene: 54195
  • Gene Overview
    MyGene.info: GUCY1B1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:82032006-82074689 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42684 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GUCY1B1, guanylate cyclase 1 soluble subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GUCY1B1, guanylate cyclase 1 soluble subunit beta 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GC-SB3, GC-S-beta-1, GUC1B3, GUCB3, GUCSB3, GUCY1B3
  • Links
    NCBI Gene ID: 2983
    neXtProt AC: NX_Q02153
    UniProt: Q02153

  • Chr Location
    4q32.1; chr4:155758973-155807642 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 3 alleles in 5 genetic backgrounds
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice that bypass neonatal lethality die prematurely due to severe gastrointestinal obstruction and exhibit hypertension, reduced heart rate, lack of glycerol trinitrate-induced drop in systolic pressure, and lack of a nitric oxide effect on aortic relaxation and platelet aggregation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000051753 VEGA Gene Model | MGI Sequence Detail 42684 C57BL/6J ±  kb
    transcript OTTMUST00000131449 VEGA | MGI Sequence Detail 3223 Not Applicable  
    polypeptide OTTMUSP00000070277 VEGA | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      333 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR011645 Haem NO binding associated
      IPR011644 Heme NO-binding
      IPR038158 H-NOX domain superfamily
      IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
      IPR029787 Nucleotide cyclase
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
    • Latest
      J:233458 Hoffmann LS, et al., Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat Commun. 2015;6:7235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory