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Gucy1b3
Gene Detail
Symbol

Name
ID
Gucy1b3
guanylate cyclase 1, soluble, beta 3
MGI:1860604
Synonyms
beta 1 sGC
Feature Type
protein coding gene
Genetic Map
Chromosome 3
35.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:82032045-82074689 bp, - strand
From VEGA annotation of GRCm38

  42645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GUCY1B3
Protein SuperFamily: soluble guanylate cyclase
Gene Tree: Gucy1b3

Human
homologs
GUCY1B3, guanylate cyclase 1, soluble, beta 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2983
neXtProt AC: NX_Q02153

Human Synonyms: GC-SB3, GC-S-beta-1, GUC1B3, GUCB3, GUCSB3, GUCY1B1

Human Chr (Location): 4q31.3-q33; chr4:155758973-155807642 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice that bypass neonatal lethality die prematurely due to severe gastrointestinal obstruction and exhibit hypertension, reduced heart rate, lack of glycerol trinitrate-induced drop in systolic pressure, and lack of a nitric oxide effect on aortic relaxation and platelet aggregation.
 
Phenotype Images(2)
Interactions
Gucy1b3 interacts with 222 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component cytoplasm, guanylate cyclase complex, soluble, ...
Function GTP binding, guanylate cyclase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (399)    Tissues (131)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 397
RT-PCR 2
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gucy1b3    NEW 
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(6) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000051753 (Evidence)
Ensembl Gene Model ENSMUSG00000028005 (Evidence)
Entrez Gene 54195 (Evidence)
DFCI TC1578457, TC1596647
DoTS DT.101388370, DT.526512
NIA Mouse Gene Index U024188
EC 4.6.1.2
Consensus CDS Project CCDS38460.1
International Mouse Phenotyping Consortium Status Gucy1b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051753 VEGA Gene Model | MGI Sequence Detail 42645 C57BL/6J ±  kb
transcript OTTMUST00000130448 VEGA | MGI Sequence Detail 3171 Not Applicable 
polypeptide OTTMUSP00000069898 VEGA | MGI Sequence Detail 609 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR011645 Haem NO binding associated
InterPro IPR011644 Heme-NO binding
InterPro IPR024096 NO signalling/Golgi transport ligand-binding domain
Protein Ontology PR:000008351 guanylate cyclase soluble subunit beta-1
References
(Earliest) J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
(Latest) J:215846 Lies B, et al., Correlation of cellular expression with function of NO-sensitive guanylyl cyclase in the murine lower urinary tract. J Physiol. 2013 Nov 1;591(Pt 21):5365-75
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory