Prpf40a MGI Mouse Gene Detail - MGI:1860512 - pre-mRNA processing factor 40A

Symbol

Prpf40a
Name

pre-mRNA processing factor 40A
Synonyms

2810012K09Rik, FBP11, Fnbp3

Feature Type

protein coding gene
IDs

MGI:1860512
NCBI Gene: 56194
Gene Overview

MyGene.info: PRPF40A
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:53134704-53191284 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 30.69 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

265 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860512	protein coding gene	Chr2:53134702-53191438 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025738	protein coding gene	Chr2:52523342-52580917 (-)
A/J	MGP_AJ_G0025714	protein coding gene	Chr2:50481373-50537730 (-)
AKR/J	MGP_AKRJ_G0025684	protein coding gene	Chr2:51926357-51984258 (-)
BALB/cJ	MGP_BALBcJ_G0025709	protein coding gene	Chr2:50586233-50643061 (-)
C3H/HeJ	MGP_C3HHeJ_G0025470	protein coding gene	Chr2:51950759-52007902 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026155	protein coding gene	Chr2:54048059-54106173 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023561	protein coding gene	Chr2:48451286-48506697 (-)
CAST/EiJ	MGP_CASTEiJ_G0024935	protein coding gene	Chr2:52068813-52125047 (-)
CBA/J	MGP_CBAJ_G0025450	protein coding gene	Chr2:56105272-56167006 (-)
DBA/2J	MGP_DBA2J_G0025581	protein coding gene	Chr2:50127662-50185168 (-)
FVB/NJ	MGP_FVBNJ_G0025543	protein coding gene	Chr2:49814471-49870814 (-)
LP/J	MGP_LPJ_G0025669	protein coding gene	Chr2:52423613-52484437 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025574	protein coding gene	Chr2:57102252-57167343 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026213	protein coding gene	Chr2:51860874-51917501 (-)
PWK/PhJ	MGP_PWKPhJ_G0024676	protein coding gene	Chr2:50016737-50073769 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024482	protein coding gene	Chr2:52090276-52147852 (-)
WSB/EiJ	MGP_WSBEiJ_G0025002	protein coding gene	Chr2:52150302-52204947 (-)

Human Ortholog

PRPF40A, pre-mRNA processing factor 40 homolog A

Vertebrate Orthologs

10

Human Ortholog

PRPF40A, pre-mRNA processing factor 40 homolog A
Orthology source: HomoloGene, HGNC
Synonyms

FBP11, FBP-11, FLAF1, FNBP3, HIP10, HIP-10, HYPA, NY-REN-6, Prp40
Links

HGNC:16463

NCBI Gene ID: 55660

neXtProt AC: NX_O75400

UniProt: O75400
Chr Location

2q23.3; chr2:152651593-152718007 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 6377
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PRPF40A
Gene Tree

Prpf40a

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

28
Genomic Mutations

1 involving Prpf40a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

136
Tissues

122
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prpf40a

ZFIN prpf40a

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Prpf40a interacts with 447 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

86
RefSeq

20
UniProt

8
CCDS

CCDS16038.1, CCDS89487.1

Ensembl

ENSMUSG00000061136 (Evidence)
NCBI Gene

56194

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061136	Ensembl Gene Model \| MGI Sequence Detail	56581	C57BL/6J	± kb
transcript	ENSMUST00000076313	Ensembl \| MGI Sequence Detail	7374	Not Applicable
polypeptide	ENSMUSP00000075655	Ensembl \| MGI Sequence Detail	953	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000013284 pre-mRNA-processing factor 40 homolog A

(term hierarchy)
InterPro Domains

IPR002713 FF domain

IPR036517 FF domain superfamily

IPR039726 Pre-mRNA-processing factor Prp40

IPR001202 WW domain

IPR036020 WW domain superfamily

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All nucleic 19

cDNA 17

Primer pair 1

Other 1

Microarray probesets 10

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MGI:1922669

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 9
Earliest

J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Prpf40a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24101	Chr2:53191214-53191260 (-)	47 bp
Tssr24100	Chr2:53191195-53191209 (-)	82 bp
Tssr24099	Chr2:53190813-53190845 (-)	455 bp
Tssr24098	Chr2:53153078-53153095 (-)	38,197 bp
Tssr24097	Chr2:53146139-53146156 (-)	45,136 bp
Tssr24096	Chr2:53145899-53145924 (-)	45,372 bp
Tssr24095	Chr2:53145350-53145376 (-)	45,921 bp
Tssr24094	Chr2:53138107-53138120 (-)	53,170 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/07/2020 MGI 6.14