Heyl
Gene Detail

Symbol Name ID

Heyl hairy/enhancer-of-split related with YRPW motif-like MGI:1860511

Synonyms

bHLHb33, Hesr3, Hey3, Hrt3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

57.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:123233556-123249875 bp, + strand From VEGA annotation of GRCm38   16320 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Heyl

Human homologs

Human Homolog		HEYL, hairy/enhancer-of-split related with YRPW motif-like
NCBI Gene ID		26508
neXtProt AC		NX_Q9NQ87
Human Synonyms		bHLHb33, HESR3, HEY3, HRT3
Human Chr (Location)		1p34.3; chr1:40089103-40105348 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit reduced TrkC+ sensory neurons in the dorsal root ganglia.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	atrioventricular valve morphogenesis, cardiac epithelial to mesenchymal transition, ...
Component	cytoplasm, nucleus, ...
Function	AF-1 domain binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (42 records)
Data Summary: Results (274)    Tissues (185)    Images (38)
Theiler Stages: 15, 16, 17, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	263
Northern blot	9
RT-PCR	2

cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(2) cDNA(36) Primer pair(1) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008972 (Evidence)
Ensembl Gene Model	ENSMUSG00000032744 (Evidence)
Entrez Gene	56198 (Evidence)
UniGene	103615
DFCI	TC1581617, TC1661426, TC1696088
DoTS	DT.487565, DT.55194730, DT.94191795
NIA Mouse Gene Index	U004769
Consensus CDS Project	CCDS18613.1
International Mouse Knockout Project Status	Heyl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008972	VEGA Gene Model | MGI Sequence Detail	16320	C57BL/6J
transcript	OTTMUST00000020367	VEGA | MGI Sequence Detail	4537	Not Applicable
polypeptide	OTTMUSP00000009337	VEGA | MGI Sequence Detail	326	Not Applicable

All sequences(35) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR003650	Orange
InterPro	IPR018352	Orange subgroup
Protein Ontology	PR:000008530	hairy/enhancer-of-split related with YRPW motif-like protein

References

(Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(80)

Other accession IDs

MGI:1353482