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Heyl
Gene Detail
Symbol

Name
ID
Heyl
hairy/enhancer-of-split related with YRPW motif-like
MGI:1860511
Synonyms
bHLHb33, Hesr3, Hey3, Hrt3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:123233556-123249875 bp, + strand
From VEGA annotation of GRCm38

  16320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: HEYL
Gene Tree: Heyl

Human
homologs
HEYL, hes-related family bHLH transcription factor with YRPW motif-like
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 26508
neXtProt AC: NX_Q9NQ87

Human Synonyms: bHLHb33, HESR3, HEY3, HRT3

Human Chr (Location): 1p34.3; chr1:39623431-39639676 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Heyl (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced TrkC+ sensory neurons in the dorsal root ganglia.
 
Interactions
Heyl interacts with 271 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process atrioventricular valve morphogenesis, cardiac epithelial to mesenchymal transition, ...
Component cytoplasm, nucleus, ...
Function AF-1 domain binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (301)    Tissues (197)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 282
Northern blot 17
RT-PCR 2
cDNA source data(37)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA HEYL ZFIN heyl    NEW 
Molecular
reagents
All nucleic(43) Genomic(2) cDNA(38) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000008972 (Evidence)
Ensembl Gene Model ENSMUSG00000032744 (Evidence)
Entrez Gene 56198 (Evidence)
UniGene 103615
DFCI TC1581617, TC1661426, TC1696088
DoTS DT.487565, DT.55194730, DT.94191795
NIA Mouse Gene Index U004769
Consensus CDS Project CCDS18613.1
International Mouse Phenotyping Consortium Status Heyl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008972 VEGA Gene Model | MGI Sequence Detail 16320 C57BL/6J ±  kb
transcript OTTMUST00000020367 VEGA | MGI Sequence Detail 4537 Not Applicable 
polypeptide OTTMUSP00000009337 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008530 hairy/enhancer-of-split related with YRPW motif-like protein
References
(Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:221164 Di Giovanni V, et al., Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
All references(95)
Other
accession IDs
MGI:1353482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory