About   Help   FAQ
Heyl
Gene Detail
Symbol

Name
ID
Heyl
hairy/enhancer-of-split related with YRPW motif-like
MGI:1860511
Synonyms
bHLHb33, Hesr3, Hey3, Hrt3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:123233556-123249875 bp, + strand
From VEGA annotation of GRCm38

  16320 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8494  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Heyl

Human
homologs
Human Homolog HEYL, hes-related family bHLH transcription factor with YRPW motif-like
NCBI Gene ID 26508
neXtProt AC  NX_Q9NQ87
Human Synonyms  bHLHb33, HESR3, HEY3, HRT3
Human Chr (Location)  1p34.3; chr1:39623431-39639676 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced TrkC+ sensory neurons in the dorsal root ganglia.
 
Interactions
Heyl interacts with 272 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process atrioventricular valve morphogenesis, cardiac epithelial to mesenchymal transition, ...
Component cytoplasm, nucleus, ...
Function AF-1 domain binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (301)    Tissues (197)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 282
Northern blot 17
RT-PCR 2
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(2) cDNA(38) Primer pair(1) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000008972 (Evidence)
Ensembl Gene ModelENSMUSG00000032744 (Evidence)
Entrez Gene56198 (Evidence)
UniGene103615
DFCITC1696088, TC1581617, TC1661426
DoTSDT.55194730, DT.487565, DT.94191795
NIA Mouse Gene IndexU004769
Consensus CDS ProjectCCDS18613.1
International Mouse Knockout Project StatusHeyl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008972 VEGA Gene Model | MGI Sequence Detail 16320 C57BL/6J ±  kb
transcript OTTMUST00000020367 VEGA | MGI Sequence Detail 4537 Not Applicable 
polypeptide OTTMUSP00000009337 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(34 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
InterPro IPR018352 Orange subgroup
Protein Ontology PR:000008530 hairy/enhancer-of-split related with YRPW motif-like protein
References
(Earliest) J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(88)
Other
accession IDs
MGI:1353482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory