About   Help   FAQ
Abcb10 Gene Detail
Summary
  • Symbol
    Abcb10
  • Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 10
  • Synonyms
    ABC-me
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860508
    NCBI Gene: 56199
Location & Maps
more
  • Sequence Map
    Chr8:123952459-123983122 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30664 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.31 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ABCB10, ATP binding cassette subfamily B member 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ABCB10, ATP binding cassette subfamily B member 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EST20237, M-ABC2, MTABC2
  • Links
    NCBI Gene ID: 23456
    neXtProt AC: NX_Q9NRK6

  • Chr Location
    1q42.13; chr1:229516582-229558695 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased response to ischemia and reperfusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031206 VEGA Gene Model | MGI Sequence Detail 30664 C57BL/6J ±  kb
transcript OTTMUST00000077306 VEGA | MGI Sequence Detail 4306 Not Applicable  
polypeptide OTTMUSP00000040853 VEGA | MGI Sequence Detail 715 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    531 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003548 ATP-binding cassette sub-family B member 10, mitochondrial
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR030260 ATP-binding cassette subfamily B member 10
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 84
    cDNA 83
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142681, MGI:2142839
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:223428 Yamamoto M, et al., Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. Mol Cell Biol. 2014 Mar;34(6):1077-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory