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Abcb10 Gene Detail
Summary
  • Symbol
    Abcb10
  • Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 10
  • Synonyms
    ABC-me
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860508
    NCBI Gene: 56199
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:123952459-123983122 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30664 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.31 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ABCB10, ATP binding cassette subfamily B member 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ABCB10, ATP binding cassette subfamily B member 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EST20237, M-ABC2, MTABC2
  • Links
    NCBI Gene ID: 23456
    neXtProt AC: NX_Q9NRK6
    UniProt: Q9NRK6

  • Chr Location
    1q42.13; chr1:229516582-229558987 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased response to ischemia and reperfusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031206 VEGA Gene Model | MGI Sequence Detail 30664 C57BL/6J ±  kb
    transcript OTTMUST00000077306 VEGA | MGI Sequence Detail 4306 Not Applicable  
    polypeptide OTTMUSP00000040853 VEGA | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      531 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003548 ATP-binding cassette sub-family B member 10, mitochondrial
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR017871 ABC transporter, conserved site
      IPR003439 ABC transporter-like
      IPR011527 ABC transporter type 1, transmembrane domain
      IPR036640 ABC transporter type 1, transmembrane domain superfamily
      IPR030260 ATP-binding cassette subfamily B member 10-like
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 84
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142681, MGI:2142839
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 7
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:252261 Sajja RK, et al., Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10?. Neurosci Lett. 2017 Jul 13;653:152-158

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory