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Proz Gene Detail
Summary
  • Symbol
    Proz
  • Name
    protein Z, vitamin K-dependent plasma glycoprotein
  • Synonyms
    1300015B06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860488
    NCBI Gene: 66901
Location & Maps
more
  • Sequence Map
    Chr8:13060908-13075006 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14099 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PROZ, protein Z, vitamin K dependent plasma glycoprotein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PROZ, protein Z, vitamin K dependent plasma glycoprotein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PZ
  • Links
    NCBI Gene ID: 8858
    neXtProt AC: NX_P22891

  • Chr Location
    13q34; chr13:113155061-113172386 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PROZ associations

Human Disease Mouse Models
       Protein Z Deficiency   OMIM: 614024
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
When unchallenged, mice homozygous for a knock-out allele do not express an obvious phenotype; however, homozygotes exhibit significantly reduced survival following collagen/epinephrine-induced thromboembolism and develop enhanced thrombosis in the ferric chloride-induced arterial injury model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031445 Ensembl Gene Model | MGI Sequence Detail 14099 C57BL/6J ±  kb
transcript ENSMUST00000033822 Ensembl | MGI Sequence Detail 2398 Not Applicable  
polypeptide ENSMUSP00000033822 Ensembl | MGI Sequence Detail 399 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    235 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013275 vitamin K-dependent protein Z
  • InterPro Domains
    IPR017857 Coagulation factor, subgroup, Gla domain
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914151
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:62716 Yin ZF, et al., Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6734-8
  • Latest
    J:225684 Butschkau A, et al., Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS One. 2014;9(12):e113554

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory