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Proz
Gene Detail
 Symbol
Name
ID
Proz
protein Z, vitamin K-dependent plasma glycoprotein
MGI:1860488
Synonyms 1300015B06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.73 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:13060908-13075006 bp, + strand
From NCBI annotation of GRCm38

  14099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2890  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: coagulation factor X
Gene Tree: Proz

Human
homologs
Human Homolog PROZ, protein Z, vitamin K-dependent plasma glycoprotein
NCBI Gene ID 8858
neXtProt AC  NX_P22891
Human Synonyms  PZ
Human Chr (Location)  13q34; chr13:113158654-113172384 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PROZ
Alleles
and
phenotypes
All alleles(4) : Targeted(3) Gene trapped(1)
 
When unchallenged, mice homozygous for a knock-out allele do not express an obvious phenotype; however, homozygotes exhibit significantly reduced survival following collagen/epinephrine-induced thromboembolism and develop enhanced thrombosis in the ferric chloride-induced arterial injury model.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular vesicular exosome
Function calcium ion binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (1)    Images (1)
Theiler Stages: 28
Assay TypeResults
Western blot 3
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031445 (Evidence)
Entrez Gene66901 (Evidence)
UniGene441140
DFCITC1587490, TC1601827, TC1636868
DoTSDT.101220759, DT.484641, DT.94171470
NIA Mouse Gene IndexU009099
Consensus CDS ProjectCCDS22105.1
International Mouse Knockout Project StatusProz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 66901 NCBI Gene Model | MGI Sequence Detail 14099 C57BL/6J ±  kb
transcript NM_025834 RefSeq | MGI Sequence Detail 2398 C57BL/6 
polypeptide Q9CQW3 UniProt | EBI | MGI Sequence Detail 399 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017857 Coagulation factor, subgroup, Gla domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
InterPro IPR001254 Peptidase S1
InterPro IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013275 vitamin K-dependent protein Z
Graphical View of Protein Domain Structure
References (Earliest) J:62716 Yin ZF, et al., Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6734-8
(Latest) J:195454 Girard TJ, et al., Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response. J Thromb Haemost. 2013 Feb;11(2):375-8
All references(31)
Other
accession IDs
MGI:1914151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory